Q96KC2
SS
Gene name |
ARL5B (ARL8) |
Protein name |
ADP-ribosylation factor-like protein 5B |
Names |
ADP-ribosylation factor-like protein 8 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
hsa:221079 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.
Autoinhibitory domains (AIDs)
Target domain |
15-140 (Small GTP-binding protein domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q96KC2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1YZG | X-ray | 200 A | A | 1-179 | PDB |
| AF-Q96KC2-F1 | Predicted | AlphaFoldDB |
141 variants for Q96KC2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs2059817648 | 2 | G>R | No | TOPMed | |
| rs1430681869 | 4 | I>T | No | gnomAD | |
| rs1156293468 | 4 | I>V | No |
TOPMed gnomAD |
|
| rs199726601 | 5 | F>L | No |
TOPMed gnomAD |
|
| rs12767957 | 6 | A>P | No | Ensembl | |
| rs1373286630 | 6 | A>V | No | gnomAD | |
| rs1461209072 | 7 | K>E | No |
TOPMed gnomAD |
|
| rs1376778256 | 10 | S>T | No | gnomAD | |
| rs1312212120 | 11 | L>F | No | gnomAD | |
| rs976875294 | 12 | F>C | No | gnomAD | |
| COSM6065538 | 13 | C>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs780532011 | 15 | Q>E | No |
ExAC gnomAD |
|
| rs1307111743 | 15 | Q>R | No | gnomAD | |
| rs2059862114 | 18 | K>E | No | Ensembl | |
| rs563873388 | 19 | V>G | No | 1000Genomes | |
|
rs1192435103 COSM69720 |
20 | I>V | ovary Variant assessed as Somatic; MODERATE impact. large_intestine [Cosmic, NCI-TCGA] | No |
NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD |
| rs1422469999 | 21 | I>L | No |
TOPMed gnomAD |
|
| rs1221230241 | 21 | I>M | No |
TOPMed gnomAD |
|
| rs749742702 | 21 | I>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA gnomAD |
| TCGA novel | 22 | V>S | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1321903304 | 29 | K>E | No | gnomAD | |
| rs1212679482 | 31 | T>S | No |
TOPMed gnomAD |
|
| rs1371962372 | 32 | I>V | No | gnomAD | |
| rs34260557 | 33 | L>F | No | Ensembl | |
| rs775435183 | 36 | F>= | Variant assessed as Somatic; LOW impact. [NCI-TCGA] | No | NCI-TCGA |
| rs762667342 | 37 | L>V | No |
ExAC gnomAD |
|
| rs1482004738 | 38 | M>I | No |
TOPMed gnomAD |
|
| rs145630985 | 39 | N>I | No |
ESP ExAC gnomAD |
|
| rs145630985 | 39 | N>S | No |
ESP ExAC gnomAD |
|
| rs201735394 | 42 | V>F | No |
1000Genomes gnomAD |
|
| rs201735394 | 42 | V>I | No |
1000Genomes gnomAD |
|
| rs927130481 | 43 | H>D | No | Ensembl | |
| rs1421876648 | 44 | T>A | No | gnomAD | |
| rs1410790869 | 45 | S>C | No | gnomAD | |
| TCGA novel | 45 | S>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1328203971 | 47 | T>A | No | gnomAD | |
| rs749993564 | 48 | I>T | No |
ExAC gnomAD |
|
| rs767134490 | 48 | I>V | No |
ExAC gnomAD |
|
| COSM1321426 | 49 | G>E | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs367712959 | 50 | S>G | No |
ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 53 | E>K | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1355449393 | 55 | I>L | No | gnomAD | |
| rs1243068229 | 57 | V>M | No | gnomAD | |
| rs1590226573 | 59 | N>D | No | Ensembl | |
| rs1195390250 | 59 | N>S | No |
TOPMed gnomAD |
|
| rs765747556 | 60 | T>S | No |
ExAC gnomAD |
|
| rs1214819809 | 61 | H>R | No | gnomAD | |
| rs753201239 | 61 | H>Y | No |
ExAC gnomAD |
|
|
rs1273232468 COSM3436421 |
63 | L>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic NCI-TCGA gnomAD |
| rs1339455050 | 64 | M>L | No | gnomAD | |
| rs2059872257 | 64 | M>T | No | Ensembl | |
| rs1422082061 | 67 | I>T | No |
TOPMed gnomAD |
|
| COSM4941308 | 69 | G>S | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs778240885 | 71 | E>G | No |
ExAC gnomAD |
|
| rs937046123 | 71 | E>K | No | Ensembl | |
| rs2059872335 | 72 | S>C | No | TOPMed | |
| COSM2132371 | 74 | R>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs751851248 | 74 | R>Q | No |
ExAC gnomAD |
|
| rs745953146 | 76 | S>A | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs1167558553 | 77 | W>* | No | gnomAD | |
| COSM4013249 | 77 | W>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| COSM1321425 | 78 | N>D | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs769934764 | 78 | N>I | No |
ExAC gnomAD |
|
| rs769934764 | 78 | N>S | No |
ExAC gnomAD |
|
| rs2059872477 | 79 | T>R | No | Ensembl | |
| rs2059872512 | 80 | Y>C | No | TOPMed | |
| rs761581848 | 83 | N>K | No |
ExAC gnomAD |
|
| rs774945318 | 86 | F>L | No |
ExAC TOPMed gnomAD |
|
| rs2059892854 | 88 | I>V | No | Ensembl | |
| rs2059892868 | 89 | L>V | No | TOPMed | |
| rs1266068684 | 90 | V>I | No |
TOPMed gnomAD |
|
| rs1200847274 | 94 | I>V | No | TOPMed | |
| rs767949340 | 97 | E>K | No |
ExAC gnomAD |
|
| rs1266683391 | 98 | R>* | No |
TOPMed gnomAD |
|
| TCGA novel | 98 | R>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 100 | A>Q | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs538867066 | 101 | I>V | No |
TOPMed gnomAD |
|
| rs750783693 | 104 | E>D | No |
ExAC TOPMed gnomAD |
|
| rs1036700453 | 104 | E>G | No | gnomAD | |
| rs1418471610 | 104 | E>K | No | gnomAD | |
| rs1418471610 | 104 | E>Q | No | gnomAD | |
| COSM4839315 | 105 | E>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1170455527 | 107 | Y>H | No |
TOPMed gnomAD |
|
| rs756404404 | 108 | R>G | No |
ExAC gnomAD |
|
| rs2059893138 | 108 | R>T | No | TOPMed | |
| rs1426468832 | 109 | M>I | No | Ensembl | |
| rs1590228691 | 112 | H>D | No | TOPMed | |
| rs766626684 | 114 | D>Y | No |
ExAC gnomAD |
|
| rs755106816 | 116 | R>Q | No |
ExAC TOPMed gnomAD |
|
| rs753949171 | 116 | R>W | No |
ExAC TOPMed gnomAD |
|
| rs2059899464 | 118 | A>P | No | TOPMed | |
| rs752754033 | 122 | I>L | No |
ExAC TOPMed |
|
| rs752754033 | 122 | I>V | No |
ExAC TOPMed |
|
| rs1564867178 | 123 | F>C | No | Ensembl | |
| rs1320088519 | 123 | F>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA gnomAD |
| COSM3806886 | 129 | M>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1229921883 | 129 | M>L | No | gnomAD | |
| rs777686752 | 131 | G>A | No |
ExAC gnomAD |
|
| rs756949714 | 132 | C>Y | No |
ExAC TOPMed gnomAD |
|
| TCGA novel | 133 | M>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs780924020 | 133 | M>V | No |
ExAC gnomAD |
|
| COSM916929 | 134 | T>A | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1486307192 | 135 | A>T | No | gnomAD | |
| rs1239729090 | 135 | A>V | No |
TOPMed gnomAD |
|
| rs1287083227 | 136 | A>D | No | gnomAD | |
|
COSM3699877 rs1221099416 |
136 | A>S | liver [Cosmic] | No |
cosmic curated TOPMed gnomAD |
| rs1221099416 | 136 | A>T | No |
TOPMed gnomAD |
|
| rs1421649857 | 138 | I>V | No | gnomAD | |
| rs372696681 | 139 | S>L | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ESP ExAC NCI-TCGA TOPMed gnomAD |
| rs372696681 | 139 | S>W | No |
ESP ExAC TOPMed gnomAD |
|
| rs142494924 | 143 | T>A | No |
ESP ExAC TOPMed gnomAD |
|
| rs2131646975 | 143 | T>N | No | 1000Genomes | |
| rs2059899892 | 144 | L>H | No | TOPMed | |
| rs2059899905 | 146 | S>T | No | Ensembl | |
| rs2059899923 | 147 | I>L | No |
TOPMed gnomAD |
|
| rs2059899969 | 149 | D>E | No | Ensembl | |
| rs11545714 | 149 | D>G | No | Ensembl | |
| rs777024389 | 149 | D>N | No |
ExAC TOPMed |
|
| rs759726684 | 150 | H>Q | No |
ExAC TOPMed gnomAD |
|
| rs2059900023 | 151 | P>S | No | Ensembl | |
| rs1435285854 | 152 | W>* | No | gnomAD | |
| rs2059900052 | 153 | H>Y | No | TOPMed | |
| rs752842238 | 154 | I>V | No |
ExAC gnomAD |
|
| rs2059900101 | 155 | Q>E | No | Ensembl | |
| rs771410625 | 165 | L>F | No | ExAC | |
| rs747241721 | 167 | Q>R | No | Ensembl | |
| rs781676669 | 168 | G>D | No |
ExAC gnomAD |
|
| rs2131647929 | 169 | L>V | No | Ensembl | |
| COSM4939241 | 172 | M>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs376615353 | 173 | T>I | No |
ESP ExAC TOPMed gnomAD |
|
| rs376615353 | 173 | T>N | No |
ESP ExAC TOPMed gnomAD |
|
| rs376615353 | 173 | T>S | No |
ESP ExAC TOPMed gnomAD |
|
| COSM3866961 | 174 | S>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs571052432 | 175 | R>G | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1030361936 | 175 | R>Q | No |
TOPMed gnomAD |
|
| rs571052432 | 175 | R>W | No |
1000Genomes ExAC TOPMed gnomAD |
|
| rs1335346940 | 176 | I>V | No | TOPMed | |
| rs2059905151 | 177 | G>S | No |
TOPMed gnomAD |
|
| rs1235589468 | 178 | V>E | No |
TOPMed gnomAD |
|
| rs749556584 | 180 | R>E | No |
ExAC gnomAD |
|
| rs749556584 | 180 | R>Q | No |
ExAC gnomAD |
No associated diseases with Q96KC2
1 regional properties for Q96KC2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 16 - 140 | IPR005225 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| protein localization to Golgi membrane | A process in which a protein is transported to, or maintained in, a location within a Golgi membrane. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
48 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P84081 | ARF2 | ADP-ribosylation factor 2 | Bos taurus (Bovine) | SS |
| P84080 | ARF1 | ADP-ribosylation factor 1 | Bos taurus (Bovine) | SS |
| Q3SZF2 | ARF4 | ADP-ribosylation factor 4 | Bos taurus (Bovine) | SS |
| Q0VC18 | ARL4D | ADP-ribosylation factor-like protein 4D | Bos taurus (Bovine) | PR |
| Q2KJ96 | ARL5A | ADP-ribosylation factor-like protein 5A | Bos taurus (Bovine) | SS |
| P49702 | ARF5 | ADP-ribosylation factor 5 | Gallus gallus (Chicken) | SS |
| P40945 | Arf4 | ADP ribosylation factor 4 | Drosophila melanogaster (Fruit fly) | SS |
| P61209 | Arf1 | ADP-ribosylation factor 1 | Drosophila melanogaster (Fruit fly) | SS |
| A6NH57 | ARL5C | Putative ADP-ribosylation factor-like protein 5C | Homo sapiens (Human) | SS |
| P18085 | ARF4 | ADP-ribosylation factor 4 | Homo sapiens (Human) | EV |
| P49703 | ARL4D | ADP-ribosylation factor-like protein 4D | Homo sapiens (Human) | PR |
| P84077 | ARF1 | ADP-ribosylation factor 1 | Homo sapiens (Human) | EV |
| P84085 | ARF5 | ADP-ribosylation factor 5 | Homo sapiens (Human) | EV |
| Q8N4G2 | ARL14 | ADP-ribosylation factor-like protein 14 | Homo sapiens (Human) | SS |
| Q969Q4 | ARL11 | ADP-ribosylation factor-like protein 11 | Homo sapiens (Human) | PR |
| P62330 | ARF6 | ADP-ribosylation factor 6 | Homo sapiens (Human) | EV |
| Q8IVW1 | ARL17A | ADP-ribosylation factor-like protein 17 | Homo sapiens (Human) | SS |
| Q9H0F7 | ARL6 | ADP-ribosylation factor-like protein 6 | Homo sapiens (Human) | SS |
| P40616 | ARL1 | ADP-ribosylation factor-like protein 1 | Homo sapiens (Human) | SS |
| P61204 | ARF3 | ADP-ribosylation factor 3 | Homo sapiens (Human) | EV |
| Q9Y689 | ARL5A | ADP-ribosylation factor-like protein 5A | Homo sapiens (Human) | SS |
| P49076 | ARF1 | ADP-ribosylation factor | Zea mays (Maize) | SS |
| P84084 | Arf5 | ADP-ribosylation factor 5 | Mus musculus (Mouse) | SS |
| P61750 | Arf4 | ADP-ribosylation factor 4 | Mus musculus (Mouse) | SS |
| Q99PE9 | Arl4d | ADP-ribosylation factor-like protein 4D | Mus musculus (Mouse) | PR |
| P61205 | Arf3 | ADP-ribosylation factor 3 | Mus musculus (Mouse) | SS |
| P84078 | Arf1 | ADP-ribosylation factor 1 | Mus musculus (Mouse) | SS |
| Q8BSL7 | Arf2 | ADP-ribosylation factor 2 | Mus musculus (Mouse) | SS |
| Q6P068 | Arl5c | ADP-ribosylation factor-like protein 5C | Mus musculus (Mouse) | SS |
| Q80ZU0 | Arl5a | ADP-ribosylation factor-like protein 5A | Mus musculus (Mouse) | SS |
| Q9D4P0 | Arl5b | ADP-ribosylation factor-like protein 5B | Mus musculus (Mouse) | SS |
| P51824 | ADP-ribosylation factor 1 | Solanum tuberosum (Potato) | SS | |
| P84082 | Arf2 | ADP-ribosylation factor 2 | Rattus norvegicus (Rat) | SS |
| P84083 | Arf5 | ADP-ribosylation factor 5 | Rattus norvegicus (Rat) | SS |
| P36407 | Trim23 | E3 ubiquitin-protein ligase TRIM23 | Rattus norvegicus (Rat) | SS |
| P61751 | Arf4 | ADP-ribosylation factor 4 | Rattus norvegicus (Rat) | SS |
| P61206 | Arf3 | ADP-ribosylation factor 3 | Rattus norvegicus (Rat) | SS |
| P84079 | Arf1 | ADP-ribosylation factor 1 | Rattus norvegicus (Rat) | SS |
| P51646 | Arl5a | ADP-ribosylation factor-like protein 5A | Rattus norvegicus (Rat) | SS |
| Q06396 | Os01g0813400 | ADP-ribosylation factor 1 | Oryza sativa subsp. japonica (Rice) | SS |
| P51823 | ARF | ADP-ribosylation factor 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q10943 | arf-1.2 | ADP-ribosylation factor 1-like 2 | Caenorhabditis elegans | SS |
| P34212 | arl-5 | ADP-ribosylation factor-like protein 5 | Caenorhabditis elegans | SS |
| Q9LQC8 | ARF2-A | ADP-ribosylation factor 2-A | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P0DH91 | ARF2-B | ADP-ribosylation factor 2-B | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P40940 | ARF3 | ADP-ribosylation factor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P36397 | ARF1 | ADP-ribosylation factor 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5M9P8 | arl6 | ADP-ribosylation factor-like protein 6 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| GVSSRARRPP | GSSRSSRRGV | TSELAWTTHP | ETGWEEVSGY | DEAMNPIRTY | QVCNVREANQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NNWLRTKFIQ | RQDVQRVYVE | LKFTVRDCNS | IPNIPGSCKE | TFNLFYYESD | TDSASANSPF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WMENPYIKVD | TIAPDESFSK | LESGRVNTKV | RSFGPLSKNG | FYLAFQDLGA | CMSLISVRAF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YKKCSNTIAG | FAIFPETLTG | AEPTSLVIAP | GTCIPNAVEV | SVPLKLYCNG | DGEWMVPVGA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CTCAAGYEPA | MKDTQCQACG | PGTFKSKQGE | GPCSPCPPNS | RTTAGAATVC | ICRSGFFRAD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ADPADSACTS | VPSAPRSVIS | NVNETSLVLE | WSEPQDAGGR | DDLLYNVICK | KCSVERRLCS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RCDDNVEFVP | RQLGLTGLTE | RRIYISKVMA | HPQYTFEIQA | VNGISSKSPY | PPHFASVNIT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TNQAAPSAVP | TMHLHSSTGN | SMTLSWTPPE | RPNGIILDYE | IKYSEKQGQG | DGIANTVTSQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KNSVRLDGLK | ANARYMVQVR | ARTVAGYGRY | SLPTEFQTTA | EDGSTSKTFQ | ELPLIVGSAT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AGLLFVIVVV | IIAIVCFRKG | MVTEQLLSSP | LGRKQRNSTD | PEYTEKLQQY | VTPGMKVYID |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PFTYEDPNEA | VREFAKEIDI | SCVKIEEVIG | AGEFGEVCRG | RLKLPGRREI | FVAIKTLKVG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YTERQRRDFL | SEASIMGQFD | HPNIIHLEGV | VTKSRPVMII | TEFMENCALD | SFLRLNDGQF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TVIQLVGMLR | GIAAGMKYLS | EMNYVHRDLA | ARNILVNSNL | VCKVSDFGLS | RFLEDDPADP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TYTSSLGGKI | PIRWTAPEAI | AYRKFTSASD | VWSYGIVMWE | VMSYGERPYW | DMSNQDVINA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VEQDYRLPPP | MDCPTALHQL | MLDCWVRDRN | LRPKFAQIVN | TLDKLIRNAA | SLKVIASVQS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GVSQPLLDRT | VPDYTTFTTV | GDWLDAIKMG | RYKENFVNAG | FASFDLVAQM | TAEDLLRIGV |
| 970 | 980 | ||||
| TLAGHQKKIL | SSIQDMRLQM | NQTLPVQV |