P61204
SS
Gene name |
ARF3 |
Protein name |
ADP-ribosylation factor 3 |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
hsa:377 |
EC number |
2.7.11.13: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
PRKCA encodes for Protein kinase C (PKC) alpha type belonging to the PCKs family and is involved in various cellular processes, including cell growth, immune response, muscle contraction, and synaptic plasticity. A well-known autoinhibitory region of the PKC family is a pseudosubstrate sequence at residues 1-30 that directly interacts with and blocks the catalytic activity of the kinase domain. Subsequences of the pseudosubstrate region are the C1 domains (C1A and C1B that bind diacylglycerol (DAG)), and the C2 domain (which binds to anionic phospholipids in a Ca2+-dependent manner). The C1A (residues 31-100) domain coordinates a network of domain-domain intramolecular interactions, including direct C1A-C2 contacts. The pseudosubstrate and C1A domains function as a single functional unit and are required to maintain autoinhibition. Additionally, the absence of the C1A domain significantly increases basal activity.
Autoinhibitory domains (AIDs)
Target domain |
16-141 (Small GTP-binding protein domain) |
Relief mechanism |
Ligand binding |
Assay |
Mutagenesis experiment |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P61204
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6II6 | X-ray | 210 A | C/D | 13-176 | PDB |
| 8P50 | EM | 404 A | B | 18-181 | PDB |
| AF-P61204-F1 | Predicted | AlphaFoldDB |
80 variants for P61204
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs1940247366 | 3 | N>S | No | gnomAD | |
| COSM1685692 | 8 | L>S | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1565707122 | 9 | L>P | No | gnomAD | |
|
COSM1188482 rs1343696419 |
10 | K>R | lung [Cosmic] | No |
cosmic curated gnomAD |
| rs1252476278 | 11 | S>I | No |
TOPMed gnomAD |
|
| rs142500831 | 13 | I>V | No |
ESP ExAC TOPMed gnomAD |
|
| rs1940246837 | 14 | G>R | No | Ensembl | |
| COSM939940 | 15 | K>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1235370712 | 15 | K>R | No | gnomAD | |
| rs1362688760 | 28 | A>S | No | gnomAD | |
| COSM2006384 | 28 | A>T | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs565039481 | 29 | G>* | No | Ensembl | |
| TCGA novel | 31 | T>N | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1332443782 | 31 | T>P | No | gnomAD | |
| rs771613112 | 32 | T>P | No |
ExAC gnomAD |
|
| rs747758626 | 33 | I>M | No |
ExAC gnomAD |
|
| rs2137578553 | 35 | Y>S | No | Ensembl | |
| rs1592239218 | 45 | T>P | No | Ensembl | |
| rs1803048 | 49 | I>V | No | Ensembl | |
| rs1367499318 | 55 | T>I | No | gnomAD | |
| rs964203889 | 62 | S>T | No | Ensembl | |
| rs1000314829 | 65 | V>A | No |
TOPMed gnomAD |
|
| rs774032503 | 68 | V>M | No |
ExAC gnomAD |
|
| COSM3986955 | 69 | G>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| TCGA novel | 75 | R>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1364486504 | 75 | R>P | No | TOPMed | |
| COSM3416892 | 75 | R>Q | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| COSM939937 | 79 | R>G | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1165099585 | 83 | Q>* | No | gnomAD | |
| rs777056448 | 87 | G>E | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA |
| TCGA novel | 87 | G>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1592238617 | 90 | F>I | No | Ensembl | |
| rs1217958873 | 92 | V>A | No | gnomAD | |
| rs1940217873 | 92 | V>I | No | TOPMed | |
| rs1278475718 | 94 | S>G | No | gnomAD | |
| rs772434603 | 97 | R>G | No |
ExAC TOPMed gnomAD |
|
| rs748329067 | 97 | R>P | No |
ExAC TOPMed gnomAD |
|
| rs748329067 | 97 | R>Q | No |
ExAC TOPMed gnomAD |
|
| rs772434603 | 97 | R>W | No |
ExAC TOPMed gnomAD |
|
| rs559433715 | 98 | E>* | No | Ensembl | |
| rs779076940 | 99 | R>* | No |
ExAC TOPMed gnomAD |
|
| rs1176865609 | 104 | R>G | No |
TOPMed gnomAD |
|
| rs753931886 | 104 | R>P | No |
ExAC TOPMed gnomAD |
|
|
COSM939936 rs753931886 |
104 | R>Q | Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs1176865609 COSM138875 |
104 | R>W | skin [Cosmic] | No |
cosmic curated TOPMed gnomAD |
| TCGA novel | 108 | M>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1298433692 | 109 | R>T | No | gnomAD | |
| rs1371506588 | 111 | L>P | No |
TOPMed gnomAD |
|
| rs781048454 | 112 | A>S | No |
ExAC gnomAD |
|
| rs542966313 | 112 | A>V | No |
1000Genomes ExAC gnomAD |
|
| rs763829888 | 113 | E>K | No |
ExAC gnomAD |
|
| rs763829888 | 113 | E>Q | No |
ExAC gnomAD |
|
| rs752332270 | 117 | R>Q | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA gnomAD |
| rs1940216239 | 118 | D>N | No | TOPMed | |
| rs1592238566 | 120 | V>I | No | Ensembl | |
| rs759029849 | 122 | L>V | No |
ExAC gnomAD |
|
| rs1592238560 | 125 | A>V | No | Ensembl | |
| rs746911324 | 134 | M>V | No |
ExAC TOPMed gnomAD |
|
| rs1360040098 | 136 | A>P | No | gnomAD | |
| rs1360040098 | 136 | A>T | No | gnomAD | |
| rs1940206563 | 139 | I>V | No | TOPMed | |
| TCGA novel | 147 | S>F | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs752526895 | 147 | S>T | No |
ExAC gnomAD |
|
| rs764869823 | 147 | S>Y | No |
ExAC gnomAD |
|
| rs754594826 | 149 | R>C | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
ExAC NCI-TCGA TOPMed gnomAD |
| rs1246000356 | 149 | R>H | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA TOPMed gnomAD |
| rs1246000356 | 149 | R>P | No |
TOPMed gnomAD |
|
| rs1940205418 | 151 | R>H | No | Ensembl | |
| rs1940205336 | 152 | N>D | No | gnomAD | |
| rs1436473762 | 155 | I>F | No | TOPMed | |
| rs369528635 | 155 | I>T | No |
ESP ExAC TOPMed gnomAD |
|
| rs773892478 | 158 | T>I | No |
ExAC gnomAD |
|
| COSM939935 | 161 | T>I | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs1290841569 | 161 | T>S | No | gnomAD | |
| rs774770771 | 171 | D>G | No |
ExAC gnomAD |
|
| rs1378522070 | 173 | L>P | No | gnomAD | |
| rs768765575 | 174 | A>G | No |
ExAC gnomAD |
|
| rs1458598929 | 175 | N>S | No |
TOPMed gnomAD |
|
| rs1208366365 | 178 | K>R | No | gnomAD | |
| rs1237083796 | 180 | K>R | No | TOPMed |
No associated diseases with P61204
15 regional properties for P61204
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 590 - 938 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 591 - 923 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class III, conserved site | 649 - 662 | IPR001824 |
| domain | Immunoglobulin subtype 2 | 224 - 298 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 423 - 499 | IPR003598-2 |
| domain | Immunoglobulin subtype | 43 - 112 | IPR003599-1 |
| domain | Immunoglobulin subtype | 121 - 205 | IPR003599-2 |
| domain | Immunoglobulin subtype | 218 - 309 | IPR003599-3 |
| domain | Immunoglobulin subtype | 321 - 409 | IPR003599-4 |
| domain | Immunoglobulin-like domain | 212 - 309 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 414 - 508 | IPR007110-2 |
| active_site | Tyrosine-protein kinase, active site | 789 - 801 | IPR008266 |
| domain | Immunoglobulin-like beta-sandwich domain | 220 - 303 | IPR013151 |
| binding_site | Protein kinase, ATP binding site | 596 - 624 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 590 - 925 | IPR020635 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.13 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
49 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KJ96 | ARL5A | ADP-ribosylation factor-like protein 5A | Bos taurus (Bovine) | SS |
| P84081 | ARF2 | ADP-ribosylation factor 2 | Bos taurus (Bovine) | SS |
| P84080 | ARF1 | ADP-ribosylation factor 1 | Bos taurus (Bovine) | SS |
| Q3SZF2 | ARF4 | ADP-ribosylation factor 4 | Bos taurus (Bovine) | SS |
| Q0VC18 | ARL4D | ADP-ribosylation factor-like protein 4D | Bos taurus (Bovine) | PR |
| Q5E9I6 | ARF3 | ADP-ribosylation factor 3 | Bos taurus (Bovine) | SS |
| P49702 | ARF5 | ADP-ribosylation factor 5 | Gallus gallus (Chicken) | SS |
| P40945 | Arf4 | ADP ribosylation factor 4 | Drosophila melanogaster (Fruit fly) | SS |
| P61209 | Arf1 | ADP-ribosylation factor 1 | Drosophila melanogaster (Fruit fly) | SS |
| Q8N4G2 | ARL14 | ADP-ribosylation factor-like protein 14 | Homo sapiens (Human) | SS |
| Q969Q4 | ARL11 | ADP-ribosylation factor-like protein 11 | Homo sapiens (Human) | PR |
| Q8IVW1 | ARL17A | ADP-ribosylation factor-like protein 17 | Homo sapiens (Human) | SS |
| P49703 | ARL4D | ADP-ribosylation factor-like protein 4D | Homo sapiens (Human) | PR |
| P62330 | ARF6 | ADP-ribosylation factor 6 | Homo sapiens (Human) | EV |
| Q9H0F7 | ARL6 | ADP-ribosylation factor-like protein 6 | Homo sapiens (Human) | SS |
| P40616 | ARL1 | ADP-ribosylation factor-like protein 1 | Homo sapiens (Human) | SS |
| P18085 | ARF4 | ADP-ribosylation factor 4 | Homo sapiens (Human) | EV |
| P84085 | ARF5 | ADP-ribosylation factor 5 | Homo sapiens (Human) | EV |
| P84077 | ARF1 | ADP-ribosylation factor 1 | Homo sapiens (Human) | EV |
| Q9Y689 | ARL5A | ADP-ribosylation factor-like protein 5A | Homo sapiens (Human) | SS |
| A6NH57 | ARL5C | Putative ADP-ribosylation factor-like protein 5C | Homo sapiens (Human) | SS |
| Q96KC2 | ARL5B | ADP-ribosylation factor-like protein 5B | Homo sapiens (Human) | SS |
| P49076 | ARF1 | ADP-ribosylation factor | Zea mays (Maize) | SS |
| P84084 | Arf5 | ADP-ribosylation factor 5 | Mus musculus (Mouse) | SS |
| P61750 | Arf4 | ADP-ribosylation factor 4 | Mus musculus (Mouse) | SS |
| Q99PE9 | Arl4d | ADP-ribosylation factor-like protein 4D | Mus musculus (Mouse) | PR |
| Q6P068 | Arl5c | ADP-ribosylation factor-like protein 5C | Mus musculus (Mouse) | SS |
| Q80ZU0 | Arl5a | ADP-ribosylation factor-like protein 5A | Mus musculus (Mouse) | SS |
| Q9D4P0 | Arl5b | ADP-ribosylation factor-like protein 5B | Mus musculus (Mouse) | SS |
| P84078 | Arf1 | ADP-ribosylation factor 1 | Mus musculus (Mouse) | SS |
| Q8BSL7 | Arf2 | ADP-ribosylation factor 2 | Mus musculus (Mouse) | SS |
| P61205 | Arf3 | ADP-ribosylation factor 3 | Mus musculus (Mouse) | SS |
| P51824 | ADP-ribosylation factor 1 | Solanum tuberosum (Potato) | SS | |
| P84082 | Arf2 | ADP-ribosylation factor 2 | Rattus norvegicus (Rat) | SS |
| P51646 | Arl5a | ADP-ribosylation factor-like protein 5A | Rattus norvegicus (Rat) | SS |
| P84083 | Arf5 | ADP-ribosylation factor 5 | Rattus norvegicus (Rat) | SS |
| P36407 | Trim23 | E3 ubiquitin-protein ligase TRIM23 | Rattus norvegicus (Rat) | SS |
| P61751 | Arf4 | ADP-ribosylation factor 4 | Rattus norvegicus (Rat) | SS |
| P84079 | Arf1 | ADP-ribosylation factor 1 | Rattus norvegicus (Rat) | SS |
| P61206 | Arf3 | ADP-ribosylation factor 3 | Rattus norvegicus (Rat) | SS |
| P51823 | ARF | ADP-ribosylation factor 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q06396 | Os01g0813400 | ADP-ribosylation factor 1 | Oryza sativa subsp. japonica (Rice) | SS |
| P34212 | arl-5 | ADP-ribosylation factor-like protein 5 | Caenorhabditis elegans | SS |
| Q10943 | arf-1.2 | ADP-ribosylation factor 1-like 2 | Caenorhabditis elegans | SS |
| P40940 | ARF3 | ADP-ribosylation factor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P0DH91 | ARF2-B | ADP-ribosylation factor 2-B | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P36397 | ARF1 | ADP-ribosylation factor 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LQC8 | ARF2-A | ADP-ribosylation factor 2-A | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5M9P8 | arl6 | ADP-ribosylation factor-like protein 6 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEGSDNNGD | PQQQGAEGEA | VGENKMKSRL | RKGALKKKNV | FNVKDHCFIA | RFFKQPTFCS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HCKDFICGYQ | SGYAWMGFGK | QGFQCQVCSY | VVHKRCHEYV | TFICPGKDKG | IDSDSPKTQH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NFEPFTYAGP | TFCDHCGSLL | YGIYHQGLKC | SACDMNVHAR | CKENVPSLCG | CDHTERRGRI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YLEINVKENL | LTVQIKEGRN | LIPMDPNGLS | DPYVKVKLIP | DDKDQSKKKT | RTIKACLNPV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WNETLTYDLK | PEDKDRRILI | EVWDWDRTSR | NDFMGALSFG | ISEIIKNPTN | GWFKLLTQDE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GEYYNVPCAD | DEQDLLKLKQ | KPSQKKPMVM | RSDTNTHTSS | KKDMIRATDF | NFIKVLGKGS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FGKVLLAERK | GSEELYAIKI | LKKDVIIQDD | DVECTMIEKR | VLALGEKPPF | LVQLHSCFQT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MDRLFFVMEY | VNGGDLMFQI | QQFGKFKEPV | AVFYAAEIAA | GLFFLHTKGI | LYRDLKLDNV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LLDADGHVKI | ADFGMCKENI | VGDKTTKTFC | GTPDYIAPEI | ILYQPYGKSV | DWWAYGVLLY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EMLVGQPPFD | GEDEEELFAA | ITDHNVSYPK | SLSKEAKEAC | KGFLTKQPNK | RLGCGSSGEE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DVRLHPFFRR | IDWEKIENRE | VQPPFKPKIK | HRKDVSNFDK | QFTSEKTDLT | PTDKVFMMNL |
| 670 | |||||
| DQSEFVGFSY | MNPEYVFSP |