AiPD: Autoinhibited Protein Database

Q96D96

Gene name	HVCN1 (VSOP, UNQ578/PRO1140)
Protein name	Voltage-gated hydrogen channel 1
Names	Hydrogen voltage-gated channel 1, HV1, Voltage sensor domain-only protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:84329
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

14-111 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

14-111 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q96D96

Entry ID	Method	Resolution	Chain	Position	Source
3A2A	X-ray	200 A	A/B/C/D	221-273	PDB
5OQK	NMR	-	A	83-226	PDB
AF-Q96D96-F1	Predicted				AlphaFoldDB

195 variants for Q96D96

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA386700956 rs1593525124	3	T>S		No	ClinGen Ensembl
rs778792393 CA386700941	4	W>*		No	ClinGen ExAC gnomAD
rs778792393 CA6787243	4	W>C		No	ClinGen ExAC gnomAD
rs1257410982 CA386700934	5	D>A		No	ClinGen TOPMed
CA6787239 rs370561510	5	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6787241 rs559851829	5	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs559851829 CA6787242	5	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6787237 rs766179586	6	E>D		No	ClinGen ExAC TOPMed gnomAD
CA6787238 rs147424254	6	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA243556408 rs147424254	6	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs753375631 CA6787215	10	T>N		No	ClinGen ExAC TOPMed gnomAD
CA6787214 rs552782188	11	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA386699737 rs552782188	11	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6787213 rs760337938	11	R>H		No	ClinGen ExAC TOPMed gnomAD
CA243546626 rs760337938	11	R>L		No	ClinGen ExAC TOPMed gnomAD
CA386699733 rs775297243	12	R>K		No	ClinGen ExAC gnomAD
rs775297243 CA6787212	12	R>T		No	ClinGen ExAC gnomAD
rs1165810946 CA386699717	14	K>N		No	ClinGen TOPMed
CA386699715 rs1357398824	15	V>M		No	ClinGen gnomAD
rs1291512351 CA386699704	16	A>V		No	ClinGen gnomAD
CA6787209 rs376751024	18	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs771450218 CA6787208	20	R>K		No	ClinGen ExAC TOPMed gnomAD
CA386699679 rs1463300804 COSM3739425	20	R>S	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
rs749821428 CA6787207	21	M>I		No	ClinGen ExAC gnomAD
CA386699673 rs1169810671	21	M>T		No	ClinGen TOPMed gnomAD
CA386699677 rs1352574295	21	M>V		No	ClinGen gnomAD
CA243546589 rs925896693	23	K>Q		No	ClinGen TOPMed
rs773231576 CA6787206	26	R>K		No	ClinGen ExAC TOPMed
CA6787205 rs769864583	27	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA386699630 rs1276577831	27	H>R		No	ClinGen TOPMed
CA386699632 rs1185155371	27	H>Y		No	ClinGen gnomAD
rs1219026855 CA386699620	28	F>L		No	ClinGen TOPMed
CA386699616 rs1310338299	29	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1298488498 CA386699603	30	V>A		No	ClinGen TOPMed gnomAD
rs1447326649 CA386699595	31	V>A		No	ClinGen gnomAD
rs773321967 CA6787203	31	V>M		No	ClinGen ExAC TOPMed gnomAD
CA243546553 COSM110403 rs150422240	32	G>E	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs147191036 CA6787201	34	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA386699549 rs1171917956	35	Y>C		No	ClinGen TOPMed
rs1337575370 CA386699539	36	H>Y		No	ClinGen gnomAD
CA243546528 rs200828154	37	A>G		No	ClinGen 1000Genomes TOPMed
CA6787200 rs149490522	37	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA386699523 rs200828154	37	A>V		No	ClinGen 1000Genomes TOPMed
CA243546521 rs890591558	38	W>C		No	ClinGen TOPMed
CA386699495 rs1403486741	40	I>V		No	ClinGen TOPMed
CA6787199 rs757178517	41	N>S		No	ClinGen ExAC TOPMed gnomAD
CA243546504 rs201649099	42	Y>D		No	ClinGen 1000Genomes
rs1566036747 CA386699476	42	Y>S		No	ClinGen Ensembl
TCGA novel	43	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386699464 rs1334793107	43	K>R		No	ClinGen Ensembl
CA386699442 rs1309371197 COSM1235762 CA386699443	45	W>R	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated gnomAD
CA243546487 rs369937599	50	E>G		No	ClinGen gnomAD
rs535442941 CA243546479	52	E>A		No	ClinGen 1000Genomes
CA386699352 rs1296357060	52	E>D		No	ClinGen TOPMed
rs755674445 CA6787196	55	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA386699308 COSM1358738 rs1593458697	56	Q>E	large_intestine [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1162768271 CA386699296	57	P>L		No	ClinGen gnomAD
CA243546458 rs920878946	57	P>S		No	ClinGen TOPMed
rs1363911971 CA386699274	59	P>R		No	ClinGen gnomAD
CA386699253 rs1160783727	62	V>I		No	ClinGen gnomAD
CA386699225 rs1346961747	64	G>V		No	ClinGen TOPMed
rs150300148 CA243546426	65	E>G		No	ClinGen ESP
CA243546429 rs948351485	65	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1261835158 CA386699199	67	G>S		No	ClinGen TOPMed
CA243546407 rs992952103	68	R>K		No	ClinGen TOPMed gnomAD
CA386699185 rs992952103	68	R>T		No	ClinGen TOPMed gnomAD
rs149357113 CA6787188	69	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA386699170 rs1351430284	70	A>T		No	ClinGen gnomAD
rs549678316 CA243546391	71	A>G		No	ClinGen TOPMed gnomAD
rs763379572 CA6787187	71	A>T		No	ClinGen ExAC gnomAD
rs549678316 CA243546381	71	A>V		No	ClinGen TOPMed gnomAD
rs773718534 CA6787186	72	P>S		No	ClinGen ExAC gnomAD
TCGA novel	73	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373795218 CA6787185	73	D>N		No	ClinGen ESP ExAC gnomAD
rs776612383 CA6787183	74	V>A		No	ClinGen ExAC TOPMed gnomAD
rs528631783 CA6787184	74	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1593458322 CA386699130	75	A>S		No	ClinGen Ensembl
rs747218361 CA386699114	77	A>D		No	ClinGen ExAC TOPMed gnomAD
rs747218361 CA6787181	77	A>V		No	ClinGen ExAC TOPMed gnomAD
CA6787179 rs770864061	78	P>L		No	ClinGen ExAC gnomAD
CA386699100 rs1420330213	80	P>S		No	ClinGen TOPMed
CA6787177 rs777850110	81	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1386019556 CA386699081	83	R>M		No	ClinGen TOPMed
rs756162690 CA6787176	84	A>D		No	ClinGen ExAC TOPMed gnomAD
rs756162690 CA386699074	84	A>V		No	ClinGen ExAC TOPMed gnomAD
rs775475972	87	D>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA243546302 rs200761884	88	F>L		No	ClinGen Ensembl
rs140708722 CA6787172	91	M>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6787173 rs76006664	91	M>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA386699032 rs1237833659	91	M>V		No	ClinGen TOPMed
TCGA novel	92	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA243546288 rs887246745	92	L>M		No	ClinGen TOPMed gnomAD
CA386699018 rs1263318641	93	R>K		No	ClinGen TOPMed
CA386698965 rs1349728820	98	S>F		No	ClinGen gnomAD
CA6787169 rs763287906	99	H>Y		No	ClinGen ExAC gnomAD
TCGA novel	103	V>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386698622 rs1274866297	103	V>I		No	ClinGen gnomAD
CA386698615 rs1317210640	104	I>V		No	ClinGen gnomAD
rs1273807510 CA386698605	105	I>T		No	ClinGen gnomAD
rs1593440936 CA386698596	106	I>M		No	ClinGen Ensembl
CA386698584 rs1442524335	108	L>S		No	ClinGen gnomAD
rs1337831464 CA386698564	110	V>A		No	ClinGen TOPMed gnomAD
rs760665421 CA6787146	113	A>G		No	ClinGen ExAC gnomAD
rs1483876431 CA386698529	114	L>F		No	ClinGen gnomAD
rs767823856 CA6787144	121	I>T		No	ClinGen ExAC gnomAD
CA386698386 rs1159299472	128	Q>H		No	ClinGen gnomAD
rs551332284 CA6787142	130	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs922421964 CA243542974	131	K>N		No	ClinGen Ensembl
rs769713018 CA6787141	132	N>S		No	ClinGen ExAC gnomAD
rs770009546 CA243542969	133	N>K		No	ClinGen Ensembl
rs770183396 CA243542967	134	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA6787140 rs770183396	134	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs1292177944 CA386698315	135	A>V		No	ClinGen TOPMed gnomAD
CA386698299 rs1284592263	137	M>T		No	ClinGen TOPMed
rs1566025649 CA386697667	139	F>L		No	ClinGen Ensembl
CA243540742 rs907385822	140	H>Y		No	ClinGen TOPMed
CA6787114 rs374884864	142	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA6787115 rs768457352	142	M>T		No	ClinGen ExAC gnomAD
CA386697637 rs1435366457	143	S>G		No	ClinGen TOPMed gnomAD
rs1270989095 CA386697615	146	I>F		No	ClinGen TOPMed
CA386697599 rs1217281983	148	V>A		No	ClinGen TOPMed
CA386697601 rs1324982417	148	V>F		No	ClinGen gnomAD
rs1217894033 CA386697580	151	M>V		No	ClinGen gnomAD
rs1212903988 CA386697509	160	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs749906449 CA243540709	162	R>C		No	ClinGen Ensembl
CA243540704 rs146855907	162	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA6787109 rs146855907	162	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6787105 rs149175563	176	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA386697390 rs1187065754	177	V>A		No	ClinGen gnomAD
rs781358524 CA6787104 COSM1358736	177	V>M	large_intestine Variant assessed as Somatic; 4.62e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA386697386 rs1478496147	178	V>M		No	ClinGen gnomAD
rs369638051 CA6787103	179	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1408490466 CA386697373	180	V>A		No	ClinGen TOPMed gnomAD
TCGA novel	181	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6787100 rs763287076	185	D>E		No	ClinGen ExAC TOPMed gnomAD
CA6787101 rs754543385	185	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1477174705 CA386697337	186	I>V		No	ClinGen gnomAD
CA6787099 rs186695691	187	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6787097 rs760539481	188	L>V		No	ClinGen ExAC gnomAD
CA6787096 rs375663985	189	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs772064093 CA6787095	192	E>G		No	ClinGen ExAC gnomAD
CA6787094 rs759014369	198	L>V		No	ClinGen ExAC gnomAD
TCGA novel	204	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386697215 rs1301354729	205	R>Q		No	ClinGen TOPMed gnomAD
TCGA novel	205	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6787092 rs770439659	205	R>W		No	ClinGen ExAC gnomAD
rs1464333610 CA386697204	207	W>L		No	ClinGen gnomAD
CA243540602 rs933712812 COSM340944	208	R>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA386697199 rs748997855 COSM1358735	208	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs900179793 CA243540596	209	V>G		No	ClinGen Ensembl
CA243540599 rs543818690	209	V>M		No	ClinGen Ensembl
rs1169337878 CA386697185	211	R>W		No	ClinGen gnomAD
TCGA novel	212	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6787090 rs777929241	214	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1279045754 CA386697121	219	S>T		No	ClinGen TOPMed
CA386697094 rs1566023850	222	T>I		No	ClinGen Ensembl
COSM935006 CA386697090 rs1485712777	223	R>C	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs145225388 CA6787075	223	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA243540120 rs888235169	225	E>G		No	ClinGen TOPMed
CA6787072 rs769403674	226	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM935005 rs772902585 CA6787074	226	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs367760167 CA6787070	229	L>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6787068 rs140550678	231	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6787067 rs576433568	234	M>T		No	ClinGen 1000Genomes ExAC gnomAD
CA386696975 rs1242023221	234	M>V		No	ClinGen gnomAD
rs1046366333 CA243540077	237	Q>R		No	ClinGen TOPMed
rs140430554 CA6787066	238	L>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6787064 rs779165493	240	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6787062 rs752437553	242	I>T		No	ClinGen ExAC gnomAD
CA6787063 rs757522794	242	I>V		No	ClinGen ExAC gnomAD
rs767328878 CA6787061	244	H>N		No	ClinGen ExAC TOPMed gnomAD
rs554508796 CA243540046 COSM3810994	246	E>Q	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA6787059 rs201313963	249	C>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs766280407 CA6787058	249	C>W		No	ClinGen ExAC gnomAD
CA386696797 rs1265967192	250	S>C		No	ClinGen gnomAD
CA6787057 rs762524035	251	E>D		No	ClinGen ExAC gnomAD
CA386696661 rs1458443579	254	Q>K		No	ClinGen TOPMed
rs1397669558 CA386696658	254	Q>R		No	ClinGen TOPMed gnomAD
rs1339414592 CA386696651	255	E>*		No	ClinGen gnomAD
TCGA novel	256	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386696636 rs1334459478	257	E>*		No	ClinGen gnomAD
rs1398106619 CA386696610	260	N>K		No	ClinGen gnomAD
rs1566022192 CA386696613	260	N>S		No	ClinGen Ensembl
CA6787038 rs749901454	261	K>Q		No	ClinGen ExAC gnomAD
CA6787035 rs764873661 COSM935004	264	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs202004657 CA6787034	264	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs753559656 CA6787033	265	Q>*		No	ClinGen ExAC gnomAD
CA386696582 rs1190575369	265	Q>H		No	ClinGen TOPMed gnomAD
CA243539518 rs959478757	266	H>R		No	ClinGen TOPMed gnomAD
CA386696570 rs1253818992	267	G>E		No	ClinGen gnomAD
CA6787032 rs763898292	269	L>F		No	ClinGen ExAC gnomAD
CA6787031 rs767677920	269	L>P		No	ClinGen ExAC TOPMed gnomAD
CA386696554 rs1259966190	270	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA6787030 rs775765211	271	E>K		No	ClinGen ExAC gnomAD
rs1230424233 CA386696529	274	N>Q		No	ClinGen TOPMed

No associated diseases with Q96D96

2 regional properties for Q96D96

Type	Name	Position	InterPro Accession
domain	Ion transport domain	101 - 216	IPR005821
domain	Voltage-gated hydrogen channel 1, C-terminal membrane-localisation domain	226 - 273	IPR031844

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein Apical cell membrane ; Multi-pass membrane protein Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein Cell projection, cilium, flagellum membrane ; Multi-pass membrane protein	Detected within the principal piece of the sperm flagellum (PubMed:20144758) Detected mainly at intracellular membranes upon overexpression in HeLa cells (PubMed:20147290)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
phagocytic vesicle membrane	The lipid bilayer surrounding a phagocytic vesicle.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
secretory granule membrane	The lipid bilayer surrounding a secretory granule.
specific granule membrane	The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.

3 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
voltage-gated cation channel activity	Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated proton channel activity	Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

9 GO annotations of biological process

Name	Definition
cell redox homeostasis	Any process that maintains the redox environment of a cell or compartment within a cell.
cellular response to pH	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
cellular response to zinc ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
positive regulation of superoxide anion generation	Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.
proton transmembrane transport	The directed movement of a proton across a membrane.
regulation of intracellular pH	Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.
regulation of ion transmembrane transport	Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
response to pH	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
response to zinc ion	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5F4C0	HVCN1	Voltage-gated hydrogen channel 1	Gallus gallus (Chicken)	PR
Q3U2S8	Hvcn1	Voltage-gated hydrogen channel 1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MATWDEKAVT	RRAKVAPAER	MSKFLRHFTV	VGDDYHAWNI	NYKKWENEEE	EEEEEQPPPT
70	80	90	100	110	120
PVSGEEGRAA	APDVAPAPGP	APRAPLDFRG	MLRKLFSSHR	FQVIIICLVV	LDALLVLAEL
130	140	150	160	170	180
ILDLKIIQPD	KNNYAAMVFH	YMSITILVFF	MMEIIFKLFV	FRLEFFHHKF	EILDAVVVVV
190	200	210	220	230	240
SFILDIVLLF	QEHQFEALGL	LILLRLWRVA	RIINGIIISV	KTRSERQLLR	LKQMNVQLAA
250	260	270
KIQHLEFSCS	EKEQEIERLN	KLLRQHGLLG	EVN