Q5F4C0

PR
Gene name
HVCN1 (RCJMB04_1c7)
Protein name
Voltage-gated hydrogen channel 1
Names
Hydrogen voltage-gated channel 1, HV1
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:416871
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5F4C0

Entry ID Method Resolution Chain Position Source
AF-Q5F4C0-F1 Predicted AlphaFoldDB

No variants for Q5F4C0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5F4C0

No associated diseases with Q5F4C0

2 regional properties for Q5F4C0

Type Name Position InterPro Accession
domain Ion transport domain 62 - 178 IPR005821
domain Voltage-gated hydrogen channel 1, C-terminal membrane-localisation domain 188 - 235 IPR031844

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
voltage-gated proton channel activity Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

6 GO annotations of biological process

Name Definition
cellular response to pH Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
cellular response to zinc ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
proton transmembrane transport The directed movement of a proton across a membrane.
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
response to pH Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
response to zinc ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96D96 HVCN1 Voltage-gated hydrogen channel 1 Homo sapiens (Human) PR
Q3U2S8 Hvcn1 Voltage-gated hydrogen channel 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSRYLKHFTV VGDDPIQWSN DYQKWENEEE DNGEKDSEIK LEPSRGHVTF QDVMKKLFSS
70 80 90 100 110 120
RRFQIVIVFL VIVDALLVLG ELLMDLKIIH PDKYHIAPKV FHYLSLSILT IFLVEVGFKI
130 140 150 160 170 180
FVYGREFFHH KFEVLDSIVV VVSFILDLVL LFREHEFEAV GLLILLRLWR VARIINGIIL
190 200 210 220 230
SVKTRSEQQV SKLKQVNLKL ATKVEQLQHS CVEKEQEIER LTRMLKQHGL LSEQT