Q3U2S8
Gene name |
Hvcn1 (Bts, Vsop) |
Protein name |
Voltage-gated hydrogen channel 1 |
Names |
Hydrogen voltage-gated channel 1, HV1, Voltage sensor domain-only protein, mVSOP |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:74096 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
7 structures for Q3U2S8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3VMX | X-ray | 145 A | A/B/C/D | 220-266 | PDB |
| 3VMY | X-ray | 147 A | A/B/C/D | 220-269 | PDB |
| 3VMZ | X-ray | 155 A | A/B/C/D | 220-269 | PDB |
| 3VN0 | X-ray | 137 A | A/B/C/D | 220-269 | PDB |
| 3VYI | X-ray | 230 A | A/B/C/D/E/F/G/H/I/J/K/L | 220-269 | PDB |
| 3WKV | X-ray | 345 A | A | 73-215 | PDB |
| AF-Q3U2S8-F1 | Predicted | AlphaFoldDB |
9 variants for Q3U2S8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388777916 | 53 | E>A | No | EVA | |
| rs13478496 | 66 | E>A | No | EVA | |
| rs3388789340 | 68 | P>A | No | EVA | |
| rs3388788632 | 71 | E>A | No | EVA | |
| rs3388785913 | 78 | P>A | No | EVA | |
| rs3388759683 | 177 | S>F | No | EVA | |
| rs3388789343 | 188 | S>G | No | EVA | |
| rs3388770368 | 235 | A>T | No | EVA | |
| rs3388795914 | 254 | R>L | No | EVA |
No associated diseases with Q3U2S8
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| voltage-gated cation channel activity | Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
| voltage-gated proton channel activity | Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to pH | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. |
| cellular response to zinc ion | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. |
| positive regulation of superoxide anion generation | Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell. |
| proton transmembrane transport | The directed movement of a proton across a membrane. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
| response to pH | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. |
| response to zinc ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTSHDPKAVT | RRTKVAPTKR | MSRFLKHFTV | VGDDYHTWNV | NYKKWENEEE | EEEPAPTSAE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GEGNAEGPDA | EAGSASTPRQ | SLDFRSRLRK | LFSSHRFQVI | IICLVVLDAL | LVLAELLLDL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KIIEPDEQDY | AVTAFHYMSF | AILVFFMLEI | FFKIFVFRLE | FFHHKFEILD | AFVVVVSFVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DLVLLFKSHH | FEALGLLILL | RLWRVARIIN | GIIISVKTRS | ERQILRLKQI | NIQLATKIQH |
| 250 | 260 | ||||
| LEFSCSEKEQ | EIERLNKLLK | QNGLLGDVN |