AiPD: Autoinhibited Protein Database

Q969E2

Gene name	SCAMP4
Protein name	Secretory carrier-associated membrane protein 4
Names	Secretory carrier membrane protein 4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:113178
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

157-229 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

157-229 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q969E2

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q969E2-F1	Predicted				AlphaFoldDB

203 variants for Q969E2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1298844179 CA403174587	2	S>A		No	ClinGen TOPMed
CA304121385 rs548989217	2	S>L		No	ClinGen TOPMed gnomAD
CA403175265 rs1568770643	4	K>N		No	ClinGen Ensembl
CA403175282 rs1217877888	7	N>D		No	ClinGen TOPMed
rs1599250838 CA403175285	7	N>T		No	ClinGen Ensembl
rs977863701 CA304123100	8	F>S		No	ClinGen gnomAD
rs763858621 CA9054793	9	P>L	Variant assessed as Somatic; 4.641e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs548869200 CA9054795	10	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs530017670 CA9054794	10	P>T		No	ClinGen 1000Genomes ExAC gnomAD
CA9054796 rs765307164	12	P>S		No	ClinGen ExAC TOPMed gnomAD
rs931695419 CA403175323	13	K>N		No	ClinGen TOPMed
rs1297632863 CA403175320	13	K>R		No	ClinGen gnomAD
TCGA novel	16	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9054799 rs766663344	19	P>R		No	ClinGen ExAC gnomAD
rs1271857120 CA403175389	23	Q>E		No	ClinGen TOPMed gnomAD
rs1050190598 CA304123143	24	N>S		No	ClinGen Ensembl
CA9054804 rs765259029	27	D>N		No	ClinGen ExAC TOPMed gnomAD
rs745345583 CA9054807	31	V>A		No	ClinGen ExAC TOPMed gnomAD
rs778586587 CA9054806 CA403175446	31	V>L		No	ClinGen ExAC TOPMed gnomAD
CA9054808 rs771455488	34	Q>H		No	ClinGen ExAC gnomAD
CA403175486 rs1458801524	37	V>E		No	ClinGen gnomAD
rs776347897 CA9054812	40	I>V		No	ClinGen ExAC gnomAD
rs772989300 CA9054815	42	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9054814 rs375366278	42	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA9054816 rs763139221	43	L>V		No	ClinGen ExAC TOPMed gnomAD
CA304123196 rs369681119	44	W>S		No	ClinGen ESP
CA9054817 rs766351928	45	M>K		No	ClinGen ExAC TOPMed gnomAD
CA304123201 rs999804913	45	M>V		No	ClinGen Ensembl
CA9054818 rs751871104	46	F>L		No	ClinGen ExAC TOPMed gnomAD
CA403175560 rs1204669712	47	Y>H		No	ClinGen gnomAD
CA403175574 rs371988987	48	C>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs45562539 CA9054864 VAR_061783	49	A>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA403175582 rs1247158100	50	T>A		No	ClinGen TOPMed gnomAD
rs1247158100 CA403175580	50	T>P		No	ClinGen TOPMed gnomAD
CA304123703 rs11545061	51	L>I		No	ClinGen Ensembl
rs780673007 CA9054865	52	G>S		No	ClinGen ExAC TOPMed gnomAD
CA304123709 rs756927324	52	G>V		No	ClinGen Ensembl
CA403175598 rs1394869511	53	V>A		No	ClinGen gnomAD
rs367794381 CA9054866	53	V>I		No	ClinGen ESP ExAC gnomAD
rs367794381 CA403175595	53	V>L		No	ClinGen ESP ExAC gnomAD
rs1002867593 CA304123710	54	N>S		No	ClinGen TOPMed gnomAD
CA403175608 rs755663940	55	L>F		No	ClinGen ExAC gnomAD
rs755663940 CA9054867	55	L>V		No	ClinGen ExAC gnomAD
rs549848699 CA9054868	56	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9054870 rs748994841	57	A>S		No	ClinGen ExAC TOPMed gnomAD
CA403175640 rs1035734291	60	A>G		No	ClinGen TOPMed gnomAD
CA403175638 rs1228023782	60	A>S		No	ClinGen gnomAD
rs1035734291 CA304123722	60	A>V		No	ClinGen TOPMed gnomAD
CA304123739 rs924241882	61	W>*		No	ClinGen Ensembl
CA9054871 rs770726554	62	W>R		No	ClinGen ExAC gnomAD
rs1211349538 CA403175663	63	I>M		No	ClinGen gnomAD
CA9054873 rs199600249	64	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed
CA9054872 rs779044597	64	G>S		No	ClinGen ExAC TOPMed gnomAD
rs775644869 CA9054875	65	G>R		No	ClinGen ExAC TOPMed gnomAD
CA403175675 rs1568771315	66	G>C		No	ClinGen Ensembl
CA403175673 rs1568771315	66	G>S		No	ClinGen Ensembl
CA304123792 rs918168874	66	G>V		No	ClinGen TOPMed
rs747251785 CA9054876	67	S>L		No	ClinGen ExAC TOPMed gnomAD
CA403175684 rs1192100987	68	G>R		No	ClinGen gnomAD
rs1599251674 CA403175689	69	T>A		No	ClinGen Ensembl
CA9054879 rs762126623	69	T>I		No	ClinGen ExAC gnomAD
rs1164146885 CA403175694	70	N>H		No	ClinGen gnomAD
CA9054880 rs373186759	72	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA403175733 rs752153362	75	F>L		No	ClinGen ExAC gnomAD
rs1381664759 CA403175727	75	F>L		No	ClinGen gnomAD
CA403175729 rs1293714133	75	F>S		No	ClinGen gnomAD
CA9054886 rs200748376	76	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403175735 rs755820863 CA403175734	76	V>L		No	ClinGen ExAC TOPMed gnomAD
rs755820863 CA9054885	76	V>M		No	ClinGen ExAC TOPMed gnomAD
CA403175745 rs1333845145	77	W>C		No	ClinGen gnomAD
TCGA novel	77	W>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA403175754 rs1367839065	79	L>F		No	ClinGen gnomAD
rs745805661 CA9054891	81	F>L		No	ClinGen ExAC
CA9054892 rs373420560	82	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9054893 rs373420560	82	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1599251775 CA403175783	84	C>Y		No	ClinGen Ensembl
rs1372624687 CA403175790	85	G>D		No	ClinGen TOPMed
rs376495954 CA9054895	85	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs748395027 CA403175798	86	Y>*		No	ClinGen ExAC gnomAD
CA9054896 rs776769700	86	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA9054898 rs202002554	87	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs763472911 CA9054900	89	W>*		No	ClinGen ExAC TOPMed gnomAD
rs763472911 CA403175816	89	W>S		No	ClinGen ExAC TOPMed gnomAD
CA9054901 rs766830264	91	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA403176260 rs1404419141	91	R>W		No	ClinGen TOPMed gnomAD
rs1312496967 CA403176270	92	P>S		No	ClinGen gnomAD
CA304123933 rs968550032	93	V>I		No	ClinGen Ensembl
rs763647846 CA9054904	95	K>E		No	ClinGen ExAC TOPMed gnomAD
CA9054905 rs753503255	95	K>R		No	ClinGen ExAC gnomAD
CA403176317 rs1238211395	96	A>T		No	ClinGen gnomAD
TCGA novel	97	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs542238969 CA9054907	98	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs750198903 CA9054908	98	R>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	102	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	108	F>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	119	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201790720	131	A>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs376157594 CA9054975	133	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403176895 rs1461465903	133	G>V		No	ClinGen TOPMed
CA403176906 rs1388213346	134	W>*		No	ClinGen TOPMed
rs369144370 CA9054978	136	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403176939 rs1252071956	137	A>G		No	ClinGen TOPMed
CA9054980 rs748843955	138	I>T		No	ClinGen ExAC gnomAD
rs1433762075 CA403176945	138	I>V		No	ClinGen TOPMed gnomAD
rs1439180881 CA403176961	139	G>E		No	ClinGen TOPMed
CA403176971 rs1399161733	140	F>V		No	ClinGen gnomAD
CA403177010 rs1328778995	142	Q>R		No	ClinGen TOPMed gnomAD
CA403177083 rs1339392163	145	P>A		No	ClinGen TOPMed
CA9054981 rs377345619	145	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA403177102 rs1304322924	146	G>R		No	ClinGen gnomAD
TCGA novel	146	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA403177112 rs1370330657	146	G>V		No	ClinGen gnomAD
CA9054984 rs750361804	147	A>T		No	ClinGen ExAC TOPMed gnomAD
CA403177130 rs1341215866	148	A>T		No	ClinGen gnomAD
TCGA novel	148	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9054986 rs77329316	149	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1436056721 CA403177242	155	A>V		No	ClinGen gnomAD
CA9054987 rs548969745	156	I>N		No	ClinGen 1000Genomes ExAC gnomAD
CA403177252 rs548969745	156	I>T		No	ClinGen 1000Genomes ExAC gnomAD
rs776519756 CA9054988	157	M>T		No	ClinGen ExAC gnomAD
CA403177264 rs1253160498	157	M>V		No	ClinGen gnomAD
rs966252065 CA304133391	159	S>F		No	ClinGen Ensembl
rs765222246 CA304133410	160	V>L		No	ClinGen ExAC TOPMed gnomAD
rs765222246 CA9054990	160	V>M		No	ClinGen ExAC TOPMed gnomAD
COSM3736192 rs201575102 CA9054991	161	S>L	skin [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA403177378 rs1463536946	163	A>V		No	ClinGen gnomAD
CA304133439 rs539494798 CA9054995	164	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751930790 CA9054994	164	M>T		No	ClinGen ExAC TOPMed gnomAD
rs566168878 CA9054993	164	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1226935339 CA403177426	165	M>I		No	ClinGen gnomAD
CA9054996 rs781776069	165	M>V		No	ClinGen ExAC gnomAD
rs551729781 CA304133457	166	A>P		No	ClinGen 1000Genomes gnomAD
rs551729781 CA304133449	166	A>T		No	ClinGen 1000Genomes gnomAD
rs1013786462 CA304133466	166	A>V		No	ClinGen TOPMed gnomAD
TCGA novel	167	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA403177481 rs116369903	168	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs374167073 CA9054998	168	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9054999 rs116369903	168	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1341128116 CA403177530	170	M>T		No	ClinGen TOPMed gnomAD
CA304133490 rs937376020	170	M>V		No	ClinGen TOPMed gnomAD
CA9055027 rs748133360	172	V>M		No	ClinGen ExAC gnomAD
CA9055031 rs771117651	173	H>R		No	ClinGen ExAC gnomAD
CA9055030 rs762989468	173	H>Y		No	ClinGen ExAC gnomAD
CA9055032 rs774779763	174	R>G		No	ClinGen ExAC gnomAD
CA9055033 rs759765918	174	R>S		No	ClinGen ExAC gnomAD
rs768006549 CA9055034	175	I>M		No	ClinGen ExAC TOPMed gnomAD
CA9055035 rs775669069	177	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs201563493 CA304135108	177	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201563493 CA9055036	177	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403178015 rs1397062609	178	G>R		No	ClinGen gnomAD
CA403178026 rs1390724159	179	A>V		No	ClinGen gnomAD
rs1479085076 CA403178029	180	G>D		No	ClinGen TOPMed
CA9055038 rs754349839	180	G>S		No	ClinGen ExAC TOPMed gnomAD
CA403178035 rs1310817703	181	G>A		No	ClinGen gnomAD
rs1310817703 CA403178034	181	G>E		No	ClinGen gnomAD
CA9055040 rs201067147	181	G>R		No	ClinGen ExAC TOPMed gnomAD
CA403178040 rs1289454951	182	S>N		No	ClinGen TOPMed
rs751222117 CA9055041 CA304135125	182	S>R		No	ClinGen ExAC gnomAD
rs754570833 CA9055042	183	F>L		No	ClinGen ExAC TOPMed gnomAD
rs781068998 CA9055043	184	Q>*		No	ClinGen ExAC gnomAD
rs1255038615 CA403178065	186	A>T		No	ClinGen gnomAD
CA9055045 rs535516053	188	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1599259779 CA403178094	190	W>G		No	ClinGen Ensembl
rs1431250418 CA403178102	191	N>D		No	ClinGen gnomAD
rs200769074 CA9055048	192	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA403178114 rs1461476691	193	G>S		No	ClinGen gnomAD
rs746114708 CA9055050	194	T>I		No	ClinGen ExAC TOPMed gnomAD
CA9055053 rs373669079	196	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA9055052 rs772379340	196	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1011296764 CA304135196	197	N>D		No	ClinGen Ensembl
rs75734024 CA9055054	199	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs999407056 CA304135220	200	S>L		No	ClinGen gnomAD
TCGA novel	202	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762244270 CA9055057	203	A>P		No	ClinGen ExAC
rs866240531 CA304135230	203	A>V		No	ClinGen Ensembl
rs1398981554 CA403178225	204	Q>*		No	ClinGen TOPMed gnomAD
CA403178255 rs1479469316	206	N>D		No	ClinGen TOPMed
rs1420034700 CA403178280	207	N>K		No	ClinGen gnomAD
CA9055063 rs754449771	207	N>S		No	ClinGen ExAC gnomAD
rs754449771 CA9055062	207	N>T		No	ClinGen ExAC gnomAD
CA304135257 rs755926017	208	F>C		No	ClinGen ExAC TOPMed gnomAD
rs752379488 CA9055064	208	F>I		No	ClinGen ExAC gnomAD
rs755926017 CA9055065	208	F>Y		No	ClinGen ExAC TOPMed gnomAD
CA403178310 rs1461530470	210	G>D		No	ClinGen gnomAD
rs1419893262 CA403178304	210	G>S		No	ClinGen TOPMed gnomAD
CA403178343 rs1389626781	213	L>M		No	ClinGen TOPMed gnomAD
TCGA novel	214	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749249246 CA9055067	215	E>K		No	ClinGen ExAC TOPMed gnomAD
CA9055068 rs757210763	217	P>R		No	ClinGen ExAC TOPMed gnomAD
CA9055070 rs745985394	218	T>S		No	ClinGen ExAC gnomAD
rs1336169352 CA403178418	219	V>M		No	ClinGen gnomAD
CA9055072 rs775634101	220	P>L		No	ClinGen ExAC TOPMed gnomAD
CA9055071 rs772171627	220	P>S		No	ClinGen ExAC gnomAD
rs1243990187 CA403178430	221	S>T		No	ClinGen gnomAD
CA403178441 rs1599259963	222	Y>S		No	ClinGen Ensembl
CA9055073 rs747252952	223	P>L		No	ClinGen ExAC gnomAD
rs747252952 CA403178457	223	P>Q		No	ClinGen ExAC gnomAD
rs762334218 CA9055077	224	G>A		No	ClinGen ExAC
rs762334218 CA403178468	224	G>V		No	ClinGen ExAC
rs572977753 CA9055078	226	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs957316515 CA304135329	227	Q>R		No	ClinGen TOPMed gnomAD
CA403178521 rs1259328485	228	W>*		No	ClinGen gnomAD
rs1475520047 CA403178529	229	P>L		No	ClinGen gnomAD

No associated diseases with Q969E2

No regional properties for Q969E2

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q969E2

Functions

		Description
EC Number
Subcellular Localization	Membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
recycling endosome membrane	The lipid bilayer surrounding a recycling endosome.
trans-Golgi network membrane	The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name	Definition
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O15126	SCAMP1	Secretory carrier-associated membrane protein 1	Homo sapiens (Human)	PR
Q8K021	Scamp1	Secretory carrier-associated membrane protein 1	Mus musculus (Mouse)	PR
Q9LR68	SCAMP2	Secretory carrier-associated membrane protein 2	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MSEKENNFPP	LPKFIPVKPC	FYQNFSDEIP	VEHQVLVKRI	YRLWMFYCAT	LGVNLIACLA
70	80	90	100	110	120
WWIGGGSGTN	FGLAFVWLLL	FTPCGYVCWF	RPVYKAFRAD	SSFNFMAFFF	IFGAQFVLTV
130	140	150	160	170	180
IQAIGFSGWG	ACGWLSAIGF	FQYSPGAAVV	MLLPAIMFSV	SAAMMAIAIM	KVHRIYRGAG
190	200	210	220
GSFQKAQTEW	NTGTWRNPPS	REAQYNNFSG	NSLPEYPTVP	SYPGSGQWP