O15126
PR
Gene name |
SCAMP1 (SCAMP) |
Protein name |
Secretory carrier-associated membrane protein 1 |
Names |
Secretory carrier membrane protein 1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:9522 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O15126
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O15126-F1 | Predicted | AlphaFoldDB |
195 variants for O15126
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA360335896 rs1471229137 |
4 | F>C | No |
ClinGen TOPMed |
|
|
CA360335900 rs1443160433 |
5 | D>Y | No |
ClinGen gnomAD |
|
|
CA360335910 rs893362975 |
6 | S>N | No |
ClinGen TOPMed |
|
|
rs893362975 CA121631664 |
6 | S>T | No |
ClinGen TOPMed |
|
|
CA360335926 rs1483272772 |
8 | P>R | No |
ClinGen TOPMed gnomAD |
|
|
CA121631665 rs867676205 |
10 | A>V | No |
ClinGen Ensembl |
|
|
CA360335942 rs966268989 |
11 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
CA121631666 rs966268989 |
11 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
rs542754511 CA121631668 |
12 | P>A | No |
ClinGen TOPMed |
|
|
rs779428769 CA3317516 |
13 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA360335954 rs779428769 |
13 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA360335960 rs1476755848 |
14 | L>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1476755848 CA360335961 |
14 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
CA3317517 rs748872971 |
15 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs768070835 CA3317518 |
16 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs1328918640 CA360335980 |
17 | P>T | No |
ClinGen gnomAD |
|
|
rs1477915991 CA360336287 |
20 | D>G | No |
ClinGen gnomAD |
|
|
CA360336307 rs1205344099 |
23 | V>A | No |
ClinGen TOPMed |
|
|
CA360336312 rs1375109843 |
24 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1456757826 CA360336319 |
25 | Q>R | No |
ClinGen gnomAD |
|
|
CA360336328 TCGA novel rs1163177915 |
26 | V>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
NCI-TCGA ClinGen gnomAD |
| TCGA novel | 28 | R>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1392169308 CA360336342 |
29 | N>H | No |
ClinGen gnomAD |
|
|
CA360336360 rs1296359668 |
31 | P>L | No |
ClinGen gnomAD |
|
|
CA3317543 rs771222877 |
31 | P>T | No |
ClinGen ExAC gnomAD |
|
|
rs759682299 CA3317545 |
35 | D>E | No |
ClinGen ExAC gnomAD |
|
|
CA3317546 rs765304173 |
37 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA3317547 rs775773775 |
41 | S>L | No |
ClinGen ExAC gnomAD |
|
|
CA360336442 rs1214388599 |
44 | R>G | No |
ClinGen gnomAD |
|
| TCGA novel | 44 | R>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs767605406 CA3317549 |
45 | T>A | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA360337432 rs1446870154 |
48 | P>L | No |
ClinGen gnomAD |
|
|
rs1244090530 CA360337429 |
48 | P>S | No |
ClinGen gnomAD |
|
|
rs75278293 CA3317570 |
50 | G>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 50 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA360337444 rs1440849482 |
51 | V>M | No |
ClinGen gnomAD |
|
|
rs766180996 CA3317571 |
53 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs753642589 CA3317572 |
54 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754625657 CA3317573 |
55 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs754625657 CA360337471 |
55 | N>H | No |
ClinGen ExAC gnomAD |
|
|
CA360337483 rs1409836200 |
56 | V>G | No |
ClinGen TOPMed gnomAD |
|
|
CA360337488 rs1267492166 |
57 | P>R | No |
ClinGen TOPMed |
|
|
CA360337486 rs1303683982 |
57 | P>S | No |
ClinGen gnomAD |
|
|
rs764918144 CA3317574 |
58 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA360337514 rs1346875908 |
61 | P>R | No |
ClinGen TOPMed |
|
|
CA121637738 rs899032597 |
61 | P>T | No |
ClinGen Ensembl |
|
|
CA360337522 rs1330588709 |
63 | I>V | No |
ClinGen gnomAD |
|
|
rs752367944 CA3317575 |
69 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1272807127 CA360337582 |
71 | P>T | No |
ClinGen TOPMed |
|
|
CA3317576 rs757864357 |
72 | A>S | No |
ClinGen ExAC gnomAD |
|
|
CA360337587 rs757864357 |
72 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1233486060 CA360337618 |
76 | I>T | No |
ClinGen gnomAD |
|
|
CA360337661 rs1170278796 |
80 | H>Q | No |
ClinGen gnomAD |
|
|
rs562453126 CA3317593 |
80 | H>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3317596 rs762607304 |
86 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA360337702 rs1580677796 |
87 | L>I | No |
ClinGen Ensembl |
|
|
rs563016417 CA121637808 |
90 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA3317597 rs763582841 |
90 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA360337730 rs1580677810 |
91 | Q>R | No |
ClinGen Ensembl |
|
|
rs751098492 CA3317598 |
92 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs751098492 CA360337738 |
92 | E>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 93 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1337815041 CA360337753 |
94 | L>P | No |
ClinGen gnomAD |
|
|
CA3317599 rs376446901 |
95 | E>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3317600 rs781601107 |
96 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA360337766 rs1253126016 |
96 | R>S | No |
ClinGen TOPMed |
|
|
CA121637810 rs1040513272 |
97 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
CA121637811 rs867897885 |
98 | A>D | No |
ClinGen Ensembl |
|
|
CA360337780 rs762983897 |
99 | A>S | No |
ClinGen gnomAD |
|
|
CA121637812 rs762983897 |
99 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
| TCGA novel | 101 | L>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA360337801 rs1321584648 |
102 | D>Y | No |
ClinGen gnomAD |
|
|
rs369702031 CA3317602 |
103 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs181180317 CA121637813 |
103 | R>H | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA3317603 rs181180317 |
103 | R>P | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1053225677 CA121637815 |
104 | R>Q | No |
ClinGen TOPMed |
|
|
rs186921534 CA121637814 |
104 | R>W | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA121637816 rs902907367 |
106 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs998531808 CA121637817 |
110 | N>H | No |
ClinGen Ensembl |
|
|
rs749503378 CA3317604 |
111 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1354791577 CA360337882 |
114 | H>R | No |
ClinGen TOPMed |
|
|
rs1463057994 CA360337901 |
115 | G>D | No |
ClinGen TOPMed |
|
|
rs1170509518 CA360337906 |
116 | R>K | No |
ClinGen TOPMed |
|
|
rs761184019 CA3317619 |
122 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA121638021 rs766168946 |
122 | P>T | No |
ClinGen Ensembl |
|
|
CA121638022 rs1035570204 |
126 | N>S | No |
ClinGen Ensembl |
|
|
CA3317621 CA3317622 rs750834214 |
130 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC TOPMed gnomAD NCI-TCGA |
|
rs1251489713 CA360338031 |
134 | Y>C | No |
ClinGen TOPMed |
|
|
CA121638023 rs1060311 |
136 | D>E | No |
ClinGen gnomAD |
|
|
rs1408912356 CA360338043 |
136 | D>N | No |
ClinGen gnomAD |
|
|
CA121638024 rs904513207 |
139 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
rs754291847 CA3317624 |
141 | I>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 143 | V>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs755227122 CA3317625 |
144 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1217713171 CA360338125 |
147 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
rs937633735 CA121638025 |
148 | T>S | No |
ClinGen TOPMed |
|
|
CA360338138 rs1278110197 |
150 | K>E | No |
ClinGen gnomAD |
|
|
rs571110143 CA121638026 |
150 | K>R | No |
ClinGen 1000Genomes |
|
|
rs748433715 CA3317627 |
151 | L>I | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 151 | L>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA3317628 rs758343285 |
152 | M>L | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 155 | L>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA360338186 rs777923800 |
156 | W>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3317629 rs777923800 |
156 | W>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs772841578 CA3317639 |
159 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
CA3317642 rs754416506 |
167 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA360338276 rs1426052599 |
168 | F>V | No |
ClinGen TOPMed |
|
|
rs546816103 CA3317644 |
169 | G>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1404081113 CA360338313 |
173 | W>S | No |
ClinGen gnomAD |
|
|
rs1302682989 CA360338328 |
175 | C>F | No |
ClinGen gnomAD |
|
|
rs758704780 CA3317646 |
176 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA360338348 rs1580681855 |
178 | S>P | No |
ClinGen Ensembl |
|
|
CA3317648 rs747133518 |
181 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA3317650 rs779920399 |
188 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1224964292 CA360338463 |
195 | T>A | No |
ClinGen TOPMed |
|
| TCGA novel | 195 | T>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA360338496 rs1255427818 |
200 | V>I | No |
ClinGen gnomAD |
|
|
CA360338506 rs749258929 |
201 | C>F | No |
ClinGen ExAC TOPMed |
|
|
rs749258929 CA3317651 |
201 | C>Y | No |
ClinGen ExAC TOPMed |
|
|
rs1221617649 CA360338538 |
205 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
rs747747383 CA3317654 |
206 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1309043987 CA360338566 |
210 | F>V | No |
ClinGen TOPMed |
|
|
rs759958028 CA3317698 |
212 | S>G | No |
ClinGen ExAC |
|
|
CA3317699 rs770374938 |
212 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs775697616 CA3317700 |
212 | S>R | No |
ClinGen ExAC |
|
|
CA3317701 rs763330844 |
213 | D>Y | No |
ClinGen ExAC |
|
|
CA3317702 rs764476576 |
214 | S>I | No |
ClinGen ExAC |
|
|
CA3317703 rs751717405 |
215 | S>* | No |
ClinGen ExAC |
|
|
rs1237841667 CA360334642 |
220 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1237841667 CA360334647 |
220 | V>L | Variant assessed as Somatic; 5.003e-05 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs373924048 CA3317706 |
224 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs368063973 CA3317707 |
225 | Y>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
TCGA novel rs1580705122 CA360334731 |
226 | I>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA Ensembl |
|
CA360334795 rs1580705131 |
230 | A>S | No |
ClinGen Ensembl |
|
|
rs754845409 CA3317708 |
230 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1463084957 CA360334810 |
231 | V>A | No |
ClinGen gnomAD |
|
|
CA3317709 rs778858276 |
231 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA360334862 rs1175953128 |
236 | A>P | No |
ClinGen gnomAD |
|
|
rs1175953128 CA360334863 |
236 | A>S | No |
ClinGen gnomAD |
|
|
rs1249942428 CA360334867 |
237 | A>T | No |
ClinGen gnomAD |
|
|
CA3317710 rs752605913 |
237 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA360334882 rs1376206033 |
239 | F>S | No |
ClinGen gnomAD |
|
|
CA360334888 rs1469471279 |
240 | H>Y | No |
ClinGen gnomAD |
|
|
CA360334896 rs1176951017 |
241 | N>D | No |
ClinGen gnomAD |
|
|
CA121641838 rs112784381 |
244 | N>K | No |
ClinGen gnomAD |
|
|
CA360334920 rs1432904013 |
244 | N>S | No |
ClinGen TOPMed |
|
|
rs201591781 CA121641840 |
245 | C>F | No |
ClinGen Ensembl |
|
|
CA3317739 rs779447245 |
248 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1490192532 CA360336059 |
252 | T>I | No |
ClinGen gnomAD |
|
|
rs377285944 CA121642884 |
255 | N>H | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA3317743 rs369489512 |
255 | N>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs772454258 CA3317744 |
256 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1430274486 CA360336102 |
259 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA121642885 rs780757569 |
262 | I>L | No |
ClinGen gnomAD |
|
|
CA360336118 rs780757569 |
262 | I>V | No |
ClinGen gnomAD |
|
|
CA3317745 rs773415296 |
263 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA121642886 rs948181674 |
264 | M>T | No |
ClinGen Ensembl |
|
|
rs1202884028 CA360336146 |
265 | I>M | No |
ClinGen TOPMed |
|
|
CA360336148 rs1364424447 |
266 | I>V | No |
ClinGen gnomAD |
|
|
CA360336167 rs1304429380 |
269 | A>T | No |
ClinGen gnomAD |
|
|
CA3317746 rs760819639 |
269 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA360336192 rs1288697696 |
273 | A>T | No |
ClinGen gnomAD |
|
|
CA360336202 rs1363043974 |
274 | S>* | No |
ClinGen gnomAD |
|
|
CA3317748 rs776642657 |
275 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs762952835 CA3317749 |
277 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1561286361 CA360336228 |
279 | L>V | No |
ClinGen Ensembl |
|
|
CA360336234 rs1327956377 |
280 | V>I | No |
ClinGen TOPMed |
|
|
CA3317751 rs560949259 |
281 | M>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA360336242 rs1246887768 |
281 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA360336239 rs1358821363 |
281 | M>V | No |
ClinGen gnomAD |
|
|
CA360336251 rs1445542314 |
282 | F>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1321140383 CA360336256 |
283 | K>E | No |
ClinGen TOPMed |
|
|
CA121642887 rs565328695 |
284 | K>E | No |
ClinGen TOPMed gnomAD |
|
|
rs759640596 CA3317768 |
290 | R>G | No |
ClinGen ExAC TOPMed |
|
|
CA360336508 rs1334067745 |
291 | T>K | No |
ClinGen gnomAD |
|
|
rs1166936641 CA360336547 |
297 | E>Q | No |
ClinGen Ensembl |
|
|
CA121644775 rs768484867 |
302 | E>K | No |
ClinGen Ensembl |
|
|
rs982547144 CA121644777 |
305 | T>K | No |
ClinGen Ensembl |
|
|
CA360336609 rs1221883149 |
306 | G>S | No |
ClinGen gnomAD |
|
|
CA3317769 rs765441111 |
310 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3317771 rs761858947 |
314 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs1580725941 CA360336674 |
315 | T>I | No |
ClinGen Ensembl |
|
|
CA3317773 rs750255612 |
316 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760349410 CA3317774 |
318 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1234088647 CA360336703 |
320 | A>E | No |
ClinGen gnomAD |
|
|
rs1436942438 CA360336713 |
322 | S>P | No |
ClinGen TOPMed |
|
| TCGA novel | 323 | T>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1580725959 CA360336730 |
325 | A>T | No |
ClinGen Ensembl |
|
|
CA360336745 rs1362779711 |
327 | S>T | No |
ClinGen TOPMed |
|
|
CA360336794 rs1198186085 |
334 | K>E | No |
ClinGen gnomAD |
|
|
rs765895805 CA3317775 |
334 | K>M | No |
ClinGen ExAC gnomAD |
|
|
CA360336799 rs1470470531 |
335 | G>S | No |
ClinGen gnomAD |
|
|
rs1448745591 CA360336820 |
337 | Q>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA360336824 rs1174679203 |
338 | I>T | No |
ClinGen gnomAD |
|
|
rs200049902 CA121644778 |
338 | I>V | No |
ClinGen TOPMed |
No associated diseases with O15126
No regional properties for O15126
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O15126 | |||
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| clathrin-coated vesicle | A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of synaptic vesicle membrane | The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| recycling endosome membrane | The lipid bilayer surrounding a recycling endosome. |
| specific granule membrane | The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
| trans-Golgi network membrane | The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. |
| zymogen granule membrane | The lipid bilayer surrounding a zymogen granule. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein domain specific binding | Binding to a specific domain of a protein. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| establishment of localization in cell | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| post-Golgi vesicle-mediated transport | The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q969E2 | SCAMP4 | Secretory carrier-associated membrane protein 4 | Homo sapiens (Human) | PR |
| Q8K021 | Scamp1 | Secretory carrier-associated membrane protein 1 | Mus musculus (Mouse) | PR |
| Q9LR68 | SCAMP2 | Secretory carrier-associated membrane protein 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDFDSNPFA | DPDLNNPFKD | PSVTQVTRNV | PPGLDEYNPF | SDSRTPPPGG | VKMPNVPNTQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PAIMKPTEEH | PAYTQIAKEH | ALAQAELLKR | QEELERKAAE | LDRREREMQN | LSQHGRKNNW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PPLPSNFPVG | PCFYQDFSVD | IPVEFQKTVK | LMYYLWMFHA | VTLFLNIFGC | LAWFCVDSAR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AVDFGLSILW | FLLFTPCSFV | CWYRPLYGAF | RSDSSFRFFV | FFFVYICQFA | VHVLQAAGFH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NWGNCGWISS | LTGLNQNIPV | GIMMIIIAAL | FTASAVISLV | MFKKVHGLYR | TTGASFEKAQ |
| 310 | 320 | 330 | |||
| QEFATGVMSN | KTVQTAAANA | ASTAASSAAQ | NAFKGNQI |