AiPD: Autoinhibited Protein Database

Q92905

Gene name	COPS5 (CSN5, JAB1)
Protein name	COP9 signalosome complex subunit 5
Names	SGN5, Signalosome subunit 5, Jun activation domain-binding protein 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10987
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

246-332 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

246-332 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

15 structures for Q92905

Entry ID	Method	Resolution	Chain	Position	Source
4D10	X-ray	380 A	E/M	1-334	PDB
4D18	X-ray	408 A	E/M	12-334	PDB
4F7O	X-ray	260 A	A/B	1-257	PDB
4WSN	X-ray	550 A	E/M/U/c/k/s	14-334	PDB
5JOG	X-ray	246 A	A	2-257	PDB
5JOH	X-ray	199 A	A	2-257	PDB
5M5Q	X-ray	220 A	A	2-257	PDB
6R6H	EM	840 A	E	1-334	PDB
6R7F	EM	820 A	E	24-334	PDB
6R7H	EM	880 A	E	24-334	PDB
6R7I	EM	590 A	E	1-334	PDB
8H38	EM	425 A	E	1-334	PDB
8H3A	EM	751 A	E	1-334	PDB
8H3F	EM	673 A	E	1-334	PDB
AF-Q92905-F1	Predicted				AlphaFoldDB

117 variants for Q92905

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA371207249 rs1585721644	4	S>A		No	ClinGen Ensembl
CA4769966 rs772964914	6	S>R		No	ClinGen ExAC gnomAD
CA371207184 rs1384038745	7	G>R		No	ClinGen gnomAD
rs1443256217 CA371207148	8	M>I		No	ClinGen TOPMed gnomAD
rs1804694 CA178225754	9	A>S		No	ClinGen Ensembl
CA371207055 rs1585721541	12	T>I		No	ClinGen Ensembl
CA178225685 rs866725884	16	A>T		No	ClinGen TOPMed
rs780531661 CA4769960	16	A>V		No	ClinGen ExAC gnomAD
CA4769959 rs148576713	17	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1490543063 CA371206875	19	M>I		No	ClinGen gnomAD
rs1232078431 CA371206859	20	Q>R		No	ClinGen TOPMed
rs779252592 CA4769957	22	A>S		No	ClinGen ExAC TOPMed gnomAD
rs779252592 CA4769958	22	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4769956 rs757811563	22	A>V		No	ClinGen ExAC TOPMed gnomAD
rs764258200 CA4769954	24	S>N		No	ClinGen ExAC gnomAD
rs1333739034 CA371206675	28	I>L		No	ClinGen gnomAD
rs1482708464 CA371206628	31	Y>H		No	ClinGen Ensembl
CA371206563 rs1490507809	33	K>M		No	ClinGen TOPMed
CA4769952 rs576133944	36	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	41	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs145855785 COSM107766 CA178225628	45	W>*	skin [Cosmic]	No	ClinGen cosmic curated Ensembl
rs200023878 CA178225619	48	D>N		No	ClinGen 1000Genomes gnomAD
CA4769917 rs778376302	53	K>E		No	ClinGen ExAC gnomAD
rs866280415 CA178223794	55	C>Y		No	ClinGen Ensembl
CA371205596 rs1424094783	56	K>R		No	ClinGen gnomAD
rs1010003084 CA178223783	57	I>M		No	ClinGen TOPMed gnomAD
TCGA novel	60	L>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs748216094 CA4769915	63	L>P		No	ClinGen ExAC gnomAD
CA918281325 rs1563448122	65	M>Q		No	ClinGen Ensembl
CA4769914 rs781307881	67	M>I		No	ClinGen ExAC gnomAD
CA178223767 rs144850801	67	M>K		No	ClinGen ESP TOPMed gnomAD
rs755211980 CA4769913	68	H>Y		No	ClinGen ExAC gnomAD
rs112353634 CA178223749	69	A>T		No	ClinGen Ensembl
rs113434892 CA178223709	74	N>S		No	ClinGen Ensembl
CA178223697 rs11557198	80	L>M		No	ClinGen Ensembl
TCGA novel	81	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	81	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA178223688 rs547886299	86	D>N		No	ClinGen TOPMed
rs547886299 CA178223682	86	D>Y		No	ClinGen TOPMed
TCGA novel	88	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756985013 CA4769910	91	I>V		No	ClinGen ExAC
rs1001853949 CA178223671	93	M>L		No	ClinGen TOPMed
CA371204927 rs1269145339	93	M>T		No	ClinGen gnomAD
TCGA novel	94	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	99	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	101	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA178223655 rs11557196	109	A>S		No	ClinGen Ensembl
rs760643887 CA4769907	111	A>S		No	ClinGen ExAC gnomAD
CA371204749 rs1306668062	114	Y>F		No	ClinGen gnomAD
rs1444548992 CA371204719	118	A>S		No	ClinGen TOPMed
rs1347693682 CA371204715	119	A>T		No	ClinGen gnomAD
rs1284147503 CA371204697	121	I>T		No	ClinGen gnomAD
TCGA novel	124	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759117469 CA4769904	126	Q>H		No	ClinGen ExAC gnomAD
rs758313448 CA178222790	127	V>F		No	ClinGen Ensembl
CA371203416 rs1254987524	129	R>C		No	ClinGen TOPMed
CA178222788 rs889246427	129	R>H		No	ClinGen TOPMed
CA178222765 rs1051932630	134	I>V		No	ClinGen gnomAD
CA371203350 rs1380557410	137	Y>F		No	ClinGen TOPMed gnomAD
CA4769889 rs756075307	145	C>W		No	ClinGen ExAC gnomAD
CA371203160 rs1585716180	150	I>V		No	ClinGen Ensembl
CA371203109 rs1343218790	153	S>N		No	ClinGen gnomAD
rs775341801 CA4769887	158	N>S		No	ClinGen ExAC gnomAD
CA4769886 rs759037579	166	V>I		No	ClinGen ExAC TOPMed gnomAD
rs866340690 CA178222234	171	D>Y		No	ClinGen Ensembl
CA4769864 rs201634747	174	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA178222199 rs199708915	175	T>A		No	ClinGen 1000Genomes
rs765529888 CA4769860	176	I>T		No	ClinGen ExAC gnomAD
CA4769861 rs369630651	176	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA4769859 rs762186633	177	S>A		No	ClinGen ExAC TOPMed gnomAD
CA4769857 rs764699097	178	A>S		No	ClinGen ExAC gnomAD
TCGA novel	178	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs951219755 CA178222117	185	A>G		No	ClinGen Ensembl
CA4769853 rs372916530	185	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1289111343 CA371202707	186	F>L		No	ClinGen gnomAD
CA178221246 rs1038600714	192	G>C		No	ClinGen Ensembl
CA371201944 rs1332197567	192	G>D		No	ClinGen TOPMed
CA178221213 rs201539863	193	Y>C		No	ClinGen 1000Genomes
rs746955448 CA4769792	195	P>T		No	ClinGen ExAC gnomAD
CA371201799 rs1340467886	199	G>E		No	ClinGen TOPMed
TCGA novel	204	Q>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	206	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4769788 rs778260803	219	K>R		No	ClinGen ExAC gnomAD
CA4769789 rs778260803	219	K>T		No	ClinGen ExAC gnomAD
CA371200197 rs1229286706	223	A>D		No	ClinGen gnomAD
TCGA novel	234	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1378846658 COSM1700166 CA371200005	235	R>C	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs138638780 CA4769758	235	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	236	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1307575325 CA371199815	249	T>A		No	ClinGen gnomAD
TCGA novel	249	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1367430036 CA371199775	252	S>T		No	ClinGen TOPMed gnomAD
rs766493793 CA4769755	253	S>C		No	ClinGen ExAC gnomAD
TCGA novel	256	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1158572768 CA371197212	259	A>V		No	ClinGen TOPMed
rs759216042 CA4769726	263	T>I		No	ClinGen ExAC gnomAD
CA4769724 rs766276256	266	V>F		No	ClinGen ExAC TOPMed gnomAD
CA178212534 rs766276256	266	V>I		No	ClinGen ExAC TOPMed gnomAD
rs762937165 CA4769723	267	F>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	271	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1444521716 CA371196934	279	Q>H		No	ClinGen TOPMed
CA178212500 rs866920136	281	G>*		No	ClinGen Ensembl
TCGA novel	282	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760694418 CA178212457	282	R>Q		No	ClinGen Ensembl
CA4769718 rs769096210	286	M>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	291	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4769717 rs143525514 COSM289061	291	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs201128315 CA178212408	299	K>R		No	ClinGen 1000Genomes
CA4769712 rs757365559	304	T>A		No	ClinGen ExAC TOPMed gnomAD
CA371196166 rs1585707100	304	T>I		No	ClinGen Ensembl
CA371195561 rs1459788146	308	C>F		No	ClinGen gnomAD
rs1332891390 CA371195350	315	I>V		No	ClinGen TOPMed gnomAD
CA4769700 rs776171390	325	D>N		No	ClinGen ExAC gnomAD
CA371195042 rs776171390	325	D>Y		No	ClinGen ExAC gnomAD
CA178210511 rs541187848	333	I>M		No	ClinGen 1000Genomes
CA371194814 rs1224571316	333	I>V		No	ClinGen gnomAD
rs75381739 CA178210509	334	S>Y		No	ClinGen Ensembl

No associated diseases with Q92905

3 regional properties for Q92905

Type	Name	Position	InterPro Accession
domain	JAB1/MPN/MOV34 metalloenzyme domain	53 - 191	IPR000555
domain	MPN domain	55 - 192	IPR037518
domain	Cop9 signalosome subunit 5 C-terminal domain	251 - 329	IPR040961

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Nucleus Cytoplasm, perinuclear region Cytoplasmic vesicle, secretory vesicle, synaptic vesicle	Nuclear localization is diminished in the presence of IFIT3
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
anchoring junction	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
COP9 signalosome	A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
eukaryotic translation initiation factor 3 complex	A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
synaptic vesicle	A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.

9 GO annotations of molecular function

Name	Definition
deNEDDylase activity	An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
macrophage migration inhibitory factor binding	Binding to the cytokine, macrophage migration inhibitory factor.
metal ion binding	Binding to a metal ion.
metal-dependent deubiquitinase activity	An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
metalloendopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
metallopeptidase activity	Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
transcription coactivator activity	A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.
translation initiation factor activity	Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

13 GO annotations of biological process

Name	Definition
exosomal secretion	The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
positive regulation of DNA-binding transcription factor activity	Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
post-translational protein modification	The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
protein deneddylation	The removal of a ubiquitin-like protein of the NEDD8 type from a protein.
protein deubiquitination	The removal of one or more ubiquitin groups from a protein.
protein neddylation	Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
regulation of cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.
regulation of IRE1-mediated unfolded protein response	Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response.
regulation of JNK cascade	Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade.
regulation of protein neddylation	Any process that modulates the frequency, rate or extent of protein neddylation.
translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O35864	Cops5	COP9 signalosome complex subunit 5	Mus musculus (Mouse)	PR
Q6PC30	cops5	COP9 signalosome complex subunit 5	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MAASGSGMAQ	KTWELANNMQ	EAQSIDEIYK	YDKKQQQEIL	AAKPWTKDHH	YFKYCKISAL
70	80	90	100	110	120
ALLKMVMHAR	SGGNLEVMGL	MLGKVDGETM	IIMDSFALPV	EGTETRVNAQ	AAAYEYMAAY
130	140	150	160	170	180
IENAKQVGRL	ENAIGWYHSH	PGYGCWLSGI	DVSTQMLNQQ	FQEPFVAVVI	DPTRTISAGK
190	200	210	220	230	240
VNLGAFRTYP	KGYKPPDEGP	SEYQTIPLNK	IEDFGVHCKQ	YYALEVSYFK	SSLDRKLLEL
250	260	270	280	290	300
LWNKYWVNTL	SSSSLLTNAD	YTTGQVFDLS	EKLEQSEAQL	GRGSFMLGLE	THDRKSEDKL
310	320	330
AKATRDSCKT	TIEAIHGLMS	QVIKDKLFNQ	INIS