Q6PC30

PR
Gene name
cops5 (zgc:73130)
Protein name
COP9 signalosome complex subunit 5
Names
Signalosome subunit 5
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:393698
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

230-328 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6PC30

Entry ID Method Resolution Chain Position Source
AF-Q6PC30-F1 Predicted AlphaFoldDB

No variants for Q6PC30

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6PC30

No associated diseases with Q6PC30

3 regional properties for Q6PC30

Type Name Position InterPro Accession
domain JAB1/MPN/MOV34 metalloenzyme domain 51 - 189 IPR000555
domain MPN domain 53 - 190 IPR037518
domain Cop9 signalosome subunit 5 C-terminal domain 249 - 327 IPR040961

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Nucleus
  • Cytoplasm, perinuclear region
  • Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
COP9 signalosome A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
synaptic vesicle A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.

4 GO annotations of molecular function

Name Definition
deNEDDylase activity An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.
metal ion binding Binding to a metal ion.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

4 GO annotations of biological process

Name Definition
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
positive regulation of DNA-binding transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein.
vestibular receptor cell development The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q92905 COPS5 COP9 signalosome complex subunit 5 Homo sapiens (Human) PR
O35864 Cops5 COP9 signalosome complex subunit 5 Mus musculus (Mouse) PR
10 20 30 40 50 60
MAGSSIAMKT WELSNSMQEV QSIDEIYKYD KKQQQEILAA KPWTKDHHYF KYCKLSALAL
70 80 90 100 110 120
LKMVMHARSG GNLEVMGLML GKVDGETMII MDSFALPVEG TETRVNAQAA AYEYMAAYIE
130 140 150 160 170 180
NAKQVGRLEN AIGWYHSHPG YGCWLSGIDV STQMLNQQFQ EPFVAVVIDP TRTISAGKVN
190 200 210 220 230 240
LGAFRTYPKG YKPPDEGPSE YQTIPLNKIE DFGVHCKQYY ALEVSYFKSS LDRKLLELLW
250 260 270 280 290 300
NKYWVNTLSS SSLLTNADYT TGQVFDLSEK LEQAEAQLGR GSFMLGLDTH DRKSEDKLAK
310 320 330
ATRDSCKTTI EAIHGLMSQV IKDKLFNQVN TSAN