Q925E0
Gene name |
Sntg2 |
Protein name |
Gamma-2-syntrophin |
Names |
G2SYN, Syntrophin-5, SYN5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:268534 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q925E0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q925E0-F1 | Predicted | AlphaFoldDB |
22 variants for Q925E0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389222224 | 23 | A>V | No | EVA | |
| rs3403180208 | 24 | R>G | No | EVA | |
| rs3389235895 | 60 | V>I | No | EVA | |
| rs3389197762 | 184 | F>L | No | EVA | |
| rs3389167544 | 189 | H>Y | No | EVA | |
| rs3389231141 | 197 | T>I | No | EVA | |
| rs3389197748 | 270 | R>G | No | EVA | |
| rs3389209067 | 309 | G>R | No | EVA | |
| rs45874498 | 332 | G>C | No | EVA | |
| rs3389231162 | 333 | A>S | No | EVA | |
| rs3389231162 | 333 | A>T | No | EVA | |
| rs3401827877 | 338 | T>K | No | EVA | |
| rs3403178420 | 338 | T>K | No | EVA | |
| rs3403224880 | 339 | L>Q | No | EVA | |
| rs266019796 | 455 | D>H | No | EVA | |
| rs3389222221 | 461 | V>E | No | EVA | |
| rs3389197724 | 494 | E>V | No | EVA | |
| rs3389222289 | 498 | L>R | No | EVA | |
| rs3389235141 | 502 | D>G | No | EVA | |
| rs3389228021 | 512 | S>P | No | EVA | |
| rs261197982 | 536 | L>P | No | EVA | |
| rs3389234112 | 537 | C>S | No | EVA |
No associated diseases with Q925E0
1 regional properties for Q925E0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Class II aldolase/adducin N-terminal | 16 - 241 | IPR001303 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| dystrophin-associated glycoprotein complex | A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| sarcolemma | The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| neuroligin family protein binding | Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation. |
| PDZ domain binding | Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. |
| structural molecule activity | The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAEGSQSLA | APRGRPSHLL | VPARTKTALA | LLYDEGLENA | YDVRLKLTKE | VLTIQKQDVV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CIGGAPPGAN | HRTVTLRRQP | VGGLGLSIKG | GAEHGVPVVI | SKIFKDQAAD | QTEMLFIGDA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VLQVNGINVE | NATHEEVVHL | LRNAGDDVTI | TVEYLREAPS | FLKLPLGSPG | PSSDHSSRAS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SPLFDSGLHL | NGHCSHTAPS | SPSSPIANEP | KYEKRWLDTL | SVPLSMARIS | RYKAGTEKLR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSALEVLALD | GASTGVLQFS | TAQDCADWLR | SISTNISDLT | LQHMKMANKC | CSPCDQVVHM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GWVNERLQGA | DNSQNFRPKF | LALRGSSFYI | FGAPPVSTLD | WGRAERAYNL | CEVLFKVHKF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| WLSDNYWLQA | NLYLGLQDFD | CEDPRSYCFS | VLANHGKSHI | FSVELGSELA | VWEKAFQRAT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FMEVQRTGSK | TYLCSWQGET | LCFTVDFALG | FTCFDGKTKN | VLWRFKFSQL | KGSSDDGKTR |
| 490 | 500 | 510 | 520 | 530 | |
| VKLLFQNLDT | KQIETKELEF | QDLTAVLHCI | HSFIAAKVAS | LDPVFMDSQS | MARRYLCSS |