Q922U1
PR
Gene name |
Prpf3 |
Protein name |
U4/U6 small nuclear ribonucleoprotein Prp3 |
Names |
Pre-mRNA-splicing factor 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70767 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q922U1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q922U1-F1 | Predicted | AlphaFoldDB |
37 variants for Q922U1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388651777 | 31 | V>A | No | EVA | |
| rs3388644493 | 39 | G>S | No | EVA | |
| rs3388641366 | 82 | S>N | No | EVA | |
| rs3388638957 | 107 | G>V | No | EVA | |
| rs3388641393 | 108 | V>L | No | EVA | |
| rs3388630662 | 130 | P>L | No | EVA | |
| rs3388648939 | 147 | E>G | No | EVA | |
| rs3389584691 | 161 | S>R | No | EVA | |
| rs3388646381 | 164 | S>N | No | EVA | |
| rs3388652618 | 164 | S>R | No | EVA | |
| rs229820242 | 167 | A>P | No | EVA | |
| rs3388650719 | 171 | K>M | No | EVA | |
| rs3388651704 | 190 | S>P | No | EVA | |
| rs3388646420 | 193 | A>S | No | EVA | |
| rs3388644107 | 253 | P>H | No | EVA | |
| rs3388637992 | 287 | A>D | No | EVA | |
| rs3388644503 | 291 | E>G | No | EVA | |
| rs3388651716 | 300 | K>R | No | EVA | |
| rs3388646424 | 310 | F>L | No | EVA | |
| rs3388646383 | 354 | E>K | No | EVA | |
| rs3393378353 | 399 | F>Y | No | EVA | |
| rs3388637934 | 414 | I>F | No | EVA | |
| rs3388637943 | 418 | V>I | No | EVA | |
| rs3388651679 | 419 | E>A | No | EVA | |
| rs3388651746 | 424 | L>F | No | EVA | |
| rs3388644457 | 471 | P>S | No | EVA | |
| rs3393376810 | 472 | P>L | No | EVA | |
| rs3393378325 | 481 | L>* | No | EVA | |
| rs3388650110 | 483 | R>* | No | EVA | |
| rs3388637989 | 498 | A>T | No | EVA | |
| rs3388641329 | 512 | E>K | No | EVA | |
| rs3388641390 | 527 | V>F | No | EVA | |
| rs3388637952 | 553 | N>T | No | EVA | |
| rs3388651652 | 586 | G>W | No | EVA | |
| rs3388651763 | 599 | L>I | No | EVA | |
| rs3388652579 | 623 | A>T | No | EVA | |
| rs3388646004 | 662 | K>N | No | EVA |
No associated diseases with Q922U1
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| Cajal body | A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| U2-type precatalytic spliceosome | A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs. |
| U4/U6 x U5 tri-snRNP complex | A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| spliceosomal tri-snRNP complex assembly | The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q03338 | PRP3 | U4/U6 small nuclear ribonucleoprotein PRP3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q2KIA6 | PRPF3 | U4/U6 small nuclear ribonucleoprotein Prp3 | Bos taurus (Bovine) | PR |
| Q5ZJ85 | PRPF3 | U4/U6 small nuclear ribonucleoprotein Prp3 | Gallus gallus (Chicken) | PR |
| O43395 | PRPF3 | U4/U6 small nuclear ribonucleoprotein Prp3 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALSKRELDE | LKPWIEKTVK | RVLGFSEPTV | VTAALNCVGK | GMDKKKAADH | LKPFLDDSTL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RFVDKLFEAV | EEGRSSRHSK | SSSDRSRKRE | LKEVFGDDSE | ISKESSGVKK | RRIPRFEEVE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EEPEVIPGPP | SESPGMLTKL | QIKQMMEAAT | RQIEERKKQL | SFISPPAPQP | KTPSSSQPER |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LPIGNTIQPS | QAATFMNDAI | EKARKAAELQ | ARIQAQLALK | PGLIGNANMV | GLANLHAMGI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| APPKVELKDQ | TKPTPLILDE | QGRTVDATGK | EVELTHRMPT | LKANIRAVKR | EQFKQQLKEK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PSEDMESNTF | FDPRVSIAPS | QRQRRTFKFH | DKGKFEKIAQ | RLRTKAQLEK | LQAEISQAAR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KTGIHTSTRL | ALIAPKKELK | EGDIPEIEWW | DSYIIPNGFD | LTEENPKRED | YFGITNLVEH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PAQLNPPVDN | DTPVTLGVYL | TKKEQKKLRR | QTRREAQKEL | QEKVRLGLTP | PPEPKVRISN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LMRVLGTEAV | QDPTKVEAHV | RAQMAKRQKA | HEEANAARKL | TAEQRKVKKI | KKLKEDISQG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VHISVYRVRN | LSNPAKKFKI | EANAGQLYLT | GVVVLHKDVN | VVVVEGGPKA | QKKFKRLMLH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RIKWDEQTSN | TKGDDDEESD | EEAVKKTNKC | VLVWEGTAKD | RSFGEMKFKQ | CPTENMAREH |
| 670 | 680 | ||||
| FKKHGAEHYW | DLALSESVLE | STD |