Q03338
Gene name |
PRP3 (RNA3, YDR473C, D8035.16) |
Protein name |
U4/U6 small nuclear ribonucleoprotein PRP3 |
Names |
Pre-mRNA-splicing factor 3 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR473C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
10 structures for Q03338
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3JCM | EM | 380 A | K | 1-469 | PDB |
| 4YHU | X-ray | 270 A | A/B/C | 296-469 | PDB |
| 4YHV | X-ray | 200 A | A | 325-469 | PDB |
| 4YHW | X-ray | 325 A | A/B | 296-469 | PDB |
| 5GAN | EM | 360 A | G | 1-469 | PDB |
| 5GAP | EM | 360 A | G | 1-469 | PDB |
| 5NRL | EM | 720 A | G | 1-469 | PDB |
| 5ZWM | EM | 340 A | J | 1-469 | PDB |
| 5ZWO | EM | 390 A | J | 1-469 | PDB |
| AF-Q03338-F1 | Predicted | AlphaFoldDB |
10 variants for Q03338
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-1405824 | 8 | E>G | No | SGRP | |
| s04-1405813 | 12 | P>S | No | SGRP | |
| s04-1405630 | 73 | P>S | No | SGRP | |
| s04-1405404 | 148 | K>T | No | SGRP | |
| s04-1405365 | 161 | D>G | No | SGRP | |
| s04-1405284 | 188 | G>D | No | SGRP | |
| s04-1405039 | 270 | P>S | No | SGRP | |
| s04-1404568 | 427 | T>S | No | SGRP | |
| s04-1404517 | 444 | V>I | No | SGRP | |
| s04-1404456 | 464 | Y>F | No | SGRP |
No associated diseases with Q03338
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
| U4 snRNP | A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes. |
| U4/U6 snRNP | A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4 and U6, a heptameric ring of Sm proteins associated with U4, the Lsm2-8 heptameric ring complex associated with U6, as well as several proteins that are unique to the U4 snRNP or U6 snRNPs, some of which remain associated with the U4/U6 snRNA both while the U4 snRNP is free or assembled into a series of spliceosomal complexes. |
| U4/U6 x U5 tri-snRNP complex | A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| spliceosomal complex assembly | The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. |
| spliceosomal snRNP assembly | The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPPRNTYEKG | NPKRQNSPYY | KPSFLRREET | TNDEEKFQGH | GLKTELHSAL | KSSNLNLIRR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TYQTGENPYL | SDPHDRGSSS | RFNRRYERGL | KFYQKGEISK | RIAQERTLQK | QQEEEELKRK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKQEEDEKDK | RKLIESGDLP | NLELHEDKFL | LDLSKFKIYY | DNNHGYEWWD | TAYLDEKGEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MEKYDMNGTS | PAEEKLAEDI | DEVDDDDDDE | HPSIRYVAHP | LPEKINEAKV | SIKAYLTQHE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RKRLRRNRRK | MAREAREIKI | KLGLLPKPEP | KVKLSNMMSV | FENDQNITDP | TAWEKVVKDQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VDLRKRKHLE | ENERRHEDAI | KRRKEAVNMN | VEKPTVYHCK | VFQFKNLQNP | KIRFKLKMNS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KELSLKGLCL | RIRDDGPGII | IVVGNEKSCK | FYENLVMKRI | KWNEDFELHT | NTGDIKMDMH |
| 430 | 440 | 450 | 460 | ||
| NNSISKTWEG | YLQDCKFKGW | FMKVCNDQDS | LLRTLGQFDS | EHFYSPVQT |