Q2KIA6
Gene name |
PRPF3 |
Protein name |
U4/U6 small nuclear ribonucleoprotein Prp3 |
Names |
Pre-mRNA-splicing factor 3 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:510322 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2KIA6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2KIA6-F1 | Predicted | AlphaFoldDB |
No variants for Q2KIA6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q2KIA6 | |||||
No associated diseases with Q2KIA6
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
| U4/U6 x U5 tri-snRNP complex | A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| spliceosomal tri-snRNP complex assembly | The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALSKRELDE | LKPWIEKTVE | RVLGFSEPTV | VTAALNCVGK | GMDKKKAADH | LKPFLDDSTL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RFVDKLFEAV | EEGRSSRHSK | SSSDRSRKRD | LKEVFGDDSE | ISKESSGVKK | RRIPRFEEVE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EEPEVIPGPP | SESPGMLTKL | QIKQMMEAAT | RQIEERKKQL | SFISPPTPQP | KTPSSSQPER |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LPIGNTIQPS | QAATFMNDAI | EKARKAAELQ | ASIQAQLALK | PGLIGNANMV | GLANLHAMGI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| APPKVELKDQ | TKPTPLILDE | QGRTVDATGK | EIELTHRMPT | LKANIRAVKR | EQFKQQLKEK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PSEDMESNTF | FDPRVSIAPS | QRQRRTFKFH | DKGKFEKIAQ | RLRTKAQLEK | LQAEISQAAR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KTGIHTSTRL | ALIAPKKELK | EGDIPEIEWW | DSYIIPNGFD | LTEENPKRED | YFGITNLVEH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PAQLNPPVDN | DTPVTLGVYL | TKKEQKKLRR | QTRREAQKEL | QEKVRLGLMP | PPEPKVRISN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LMRVLGTEAV | QDPTKVEAHV | RAQMAKRQKA | HEEANAARKL | TAEQRKVKKI | KKLKEDISQG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VHISVYRVRN | LSNPAKKFKI | EANAGQLYLT | GVVVLHKDVN | VVVVEGGPKA | QKKFKRLMLH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RIKWDEQTSN | TKGDDDEESD | EEAVKKTNKC | VLVWEGTAKD | RSFGEMKFKQ | CPTENMAREH |
| 670 | 680 | ||||
| FKKHGAEHYW | DLALSESVLE | STD |