Q922P8

PR
Gene name
Tmem132a (Kiaa1583)
Protein name
Transmembrane protein 132A
Names
HSPA5-binding protein 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:98170
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

771-858 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q922P8

Entry ID Method Resolution Chain Position Source
AF-Q922P8-F1 Predicted AlphaFoldDB

59 variants for Q922P8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3409045984 27 V>L No EVA
rs3389475613 52 P>L No EVA
rs3389526020 53 E>V No EVA
rs3408943362 63 Y>* No EVA
rs3389506105 74 S>Y No EVA
rs228449961 84 P>A No EVA
rs3409137308 120 R>Q No EVA
rs3389542485 128 V>M No EVA
rs3389526068 162 H>Y No EVA
rs3389506112 163 P>T No EVA
rs3389538589 164 A>T No EVA
rs253516637 169 R>Q No EVA
rs3389493605 180 C>S No EVA
rs3389531641 272 L>M No EVA
rs3389542471 281 L>H No EVA
rs251873820 295 I>T No EVA
rs3389519863 299 P>L No EVA
rs3389519881 318 H>L No EVA
rs3389506075 335 S>T No EVA
rs3389506150 354 G>D No EVA
rs3408970012 355 G>E No EVA
rs3408943350 358 A>E No EVA
rs3389531426 363 V>I No EVA
rs3389527168 371 G>C No EVA
rs3389506115 379 D>N No EVA
rs3389434189 391 D>G No EVA
rs3389528066 394 A>V No EVA
rs3389527087 429 A>V No EVA
rs3389542519 435 E>D No EVA
rs3389522289 498 T>I No EVA
rs233812719 522 T>A No EVA
rs215362137 544 R>S No EVA
rs3389519898 610 S>F No EVA
rs3389475568 614 D>E No EVA
rs3389519897 618 G>E No EVA
rs3389506070 631 V>M No EVA
rs1134033602 648 R>Q No EVA
rs3389527126 658 A>D No EVA
rs3389520267 662 A>T No EVA
rs3389522350 669 P>L No EVA
rs244939922 680 S>T No EVA
rs3389434213 707 S>T No EVA
rs3389519837 715 Q>K No EVA
rs3389531403 734 H>Y No EVA
rs251478672 792 I>T No EVA
rs3407007420 814 G>V No EVA
rs3389493607 847 L>I No EVA
rs3407862141 865 F>S No EVA
rs3408897432 869 Y>* No EVA
rs3408897426 869 Y>C No EVA
rs3407938653 870 Q>* No EVA
rs3389520215 873 E>D No EVA
rs3389475581 876 D>N No EVA
rs3389535938 879 T>I No EVA
rs3408571271 915 E>V No EVA
rs13474955 931 V>M No EVA
rs13474956 969 T>A No EVA
rs3408571236 973 E>G No EVA
rs3389475480 988 G>A No EVA

No associated diseases with Q922P8

3 regional properties for Q922P8

Type Name Position InterPro Accession
domain Transmembrane protein TMEM132, N-terminal 44 - 163 IPR031435
domain Transmembrane protein TMEM132, C-terminal 816 - 896 IPR031436
domain Transmembrane protein family 132, middle domain 403 - 744 IPR031437

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass type I membrane protein
  • Endoplasmic reticulum membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
negative regulation of programmed cell death Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6IEE7 TMEM132E Transmembrane protein 132E Homo sapiens (Human) PR
Q14C87 TMEM132D Transmembrane protein 132D Homo sapiens (Human) PR
Q24JP5 TMEM132A Transmembrane protein 132A Homo sapiens (Human) PR
Q6IEE6 Tmem132e Transmembrane protein 132E Mus musculus (Mouse) PR
Q80WF4 Tmem132a Transmembrane protein 132A Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MTERKAAAPR GPYGAWFCLL VALALEVVRV SSNHDTLDPI YLPVALELLD APEHFRVQQV
70 80 90 100 110 120
GHYPPANSSL ASRSETFLLM QPWPRAQPLL RASYPPFATQ QVVPPRVTEP HRRPVPWDVR
130 140 150 160 170 180
AVSVEAAVTP AEPYARVLFH LKGQDWPPGP GSLPCARLHA THPAGTAHRA CRFQPSLGAC
190 200 210 220 230 240
VVELQFPSHW FSQSATTRAE LAYTLEPAGE GPGGCGLGTE EEPREQALPV GGVELHPEDP
250 260 270 280 290 300
PQYQEVPLDE AVTLRAPDVP MRPGQLFTAT LLLRHNFTAS LLTLRIKVKK GLQVIAARPA
310 320 330 340 350 360
QPTLWTAKLD RFKGSKHHTS LITCHRAGPA GPDSSPLELS EFLWVDFAVE NSTGGGVAVT
370 380 390 400 410 420
RPVTWQLEYP GQAPEAEKDK MVWEILVSER DIRALIPLAK AEELVNTAPL TGVPQRIPVR
430 440 450 460 470 480
LVTVDSGGAL EEVTEHIGCE SANTQVLQVS EACDAVFVAG QESRGAKGVR VDFWWRRLRA
490 500 510 520 530 540
SLKLTVWAPL LPLRIELTDT TLEQIRGWRV PGSAEGQLEP ETAAEEVERR SRGCRLQYQR
550 560 570 580 590 600
AGVRFLVPFA AHPLDGGRRL THLLGPDWLL DVSHLVAAHA HVQDPRIASL EGGRILVGRE
610 620 630 640 650 660
PGVTSIEVRS PLSDAILGEQ ALAVTDDKVS VLDLRVQPVM GISLSLSRGM SHPGEVTATC
670 680 690 700 710 720
WAQSALPAPK QEVALSLWLS FSDHTLAPAE LYDRNDLGLS VSAEEPSAVL PAEEQGAQLG
730 740 750 760 770 780
VVVSGVGAEG LPLHVALHPP EPCRRGRHRV PLASGTAWLG LPPLPTPVPA LPSSPVRTSP
790 800 810 820 830 840
FTEATVEGKR QIAGDMGGHV GIRGKFERAE EEAGKEENEA KEEEEDEEEM VPAPQRVTDL
850 860 870 880 890 900
ELGMYALLGI FCLAILIFLV NGVVFVLRYQ RKEPPDSATD PASPQPHNWV WLGTNQEELS
910 920 930 940 950 960
RQLDRCSSSG PPKGEGGCPC ESGAGGDAST VAPSASESPA GSSSTLARKE AGGRRKRVEF
970 980 990 1000 1010
VTFAPAPPTQ PPEEPVGAPA VQSILVAGEE DIRWVCEDMG LKDPEELRNY MERIRGSS