Q6IEE6
Gene name |
Tmem132e (Gm644) |
Protein name |
Transmembrane protein 132E |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:270893 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6IEE6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6IEE6-F1 | Predicted | AlphaFoldDB |
26 variants for Q6IEE6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs254533898 | 182 | L>M | No | EVA | |
| rs232499638 | 224 | A>V | No | EVA | |
| rs261292392 | 248 | A>S | No | EVA | |
| rs224588342 | 280 | R>W | No | EVA | |
| rs3402803255 | 375 | W>* | No | EVA | |
| rs3401283520 | 385 | E>Q | No | EVA | |
| rs3389187013 | 402 | F>L | No | EVA | |
| rs3389156420 | 426 | L>M | No | EVA | |
| rs3402594604 | 440 | V>D | No | EVA | |
| rs3402803220 | 470 | I>M | No | EVA | |
| rs3389185046 | 475 | T>I | No | EVA | |
| rs3389123242 | 481 | V>I | No | EVA | |
| rs3389195721 | 557 | R>M | No | EVA | |
| rs3389179472 | 581 | R>* | No | EVA | |
| rs3389156375 | 601 | T>P | No | EVA | |
| rs3401863278 | 634 | M>I | No | EVA | |
| rs3402507469 | 634 | M>T | No | EVA | |
| rs3389189050 | 689 | Q>H | No | EVA | |
| rs3389195695 | 698 | L>* | No | EVA | |
| rs3389196358 | 714 | T>I | No | EVA | |
| rs3389195688 | 799 | K>R | No | EVA | |
| rs3389200119 | 847 | P>L | No | EVA | |
| rs3389179526 | 857 | P>L | No | EVA | |
| rs3389123230 | 862 | A>D | No | EVA | |
| rs3389189026 | 1058 | T>I | No | EVA | |
| rs3389160263 | 1059 | P>R | No | EVA |
No associated diseases with Q6IEE6
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell body | The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| posterior lateral line neuromast hair cell development | The process whose specific outcome is the progression of a posterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q14C87 | TMEM132D | Transmembrane protein 132D | Homo sapiens (Human) | PR |
| Q24JP5 | TMEM132A | Transmembrane protein 132A | Homo sapiens (Human) | PR |
| Q6IEE7 | TMEM132E | Transmembrane protein 132E | Homo sapiens (Human) | PR |
| Q922P8 | Tmem132a | Transmembrane protein 132A | Mus musculus (Mouse) | PR |
| Q80WF4 | Tmem132a | Transmembrane protein 132A | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPGMSGRRG | AALLCLSVLL | AHAASRSHPA | SPSPPGTQAS | PILPVSYRLS | HTRLAFFLKE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ARPLTPAAIN | GSLQRSEPFV | VFQTKELPVL | NVSLGPFSTS | QVVARELLQP | SSTLDIPERL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TVNWKVRAFI | VRARVPASQP | VAQVLFYVAG | RDWDDFGVTE | RLPCVRLHAF | RDAREVRSSC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RLGGALATCL | VRAELPLAWF | GPPAPAAPPS | ARRKSPDGLE | PEAAAESQQV | ELYYTLHAPD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ASGGCGSARR | GPGPGPGAAA | RAESPTQHPL | LRIGSISLFR | PPPRRAVQEH | RLDSNLMIRL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PDRPLRPGEV | LSILLYLAPN | SSSAASPSVE | HFTLRVKAKK | GVTLLGTKSR | SGQWRVTSEL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LTGAKHSTAT | VDVAWALDTP | LPPWEGQGPL | EILQLDFEME | NFTSQSVKRR | IMWHIDYRGH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SALPDLERAV | TELTVIQRDV | QAILPLAMDT | EIINTAILTG | RTVAIPVKVI | AIEVTGLVLD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VSDLVECQSH | SEDIIKVSSS | CDYVFVSGKE | SRGSMNARVT | FRYDVLSAPL | EMTVWVPKLP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LHIELSDARL | SQVKGWRVPI | LPDRRSARES | EDEEEEEEER | RQSANRGCTL | QYQHATLQVF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TQFHTTSSEG | TDQVVTMLGP | DWLVEVTDLV | SDFMRVGDPR | VAHLVDSNTL | AGLEPGTTPF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KVVSPLTEAV | LGETLLTVTE | EKVSITQLQA | QVVASLTLSL | RPSPGSSHTI | LATTAAQPTL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SLVKQEALLS | LWLSYSDGTT | APLSLYSSRD | YGLLVSSLDE | RVATVTQDKA | FPLVVAEAEG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SGDLLRAELT | ISESCQKTKR | KSVLATTPVS | LRVHFGRDEE | DPTYDYPGPS | QPGPGGGEDE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ARGAGPPGTA | IPAGEVPGLG | TAGPVPPTED | YLPLPTGFLQ | MPRGLTDLEI | GMYALLGVFC |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LAILVFLINC | IVFVLRYRHK | RIPPEGQTSM | DHSHHWVFLG | NGQPLRVQGE | LSPPAGSALE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| TVPACCHGDH | HSSGSSQTSV | QSQVHGRGDG | SSGGSARDQT | EDPASSPTSK | RKRVKFTTFT |
| 1030 | 1040 | 1050 | 1060 | 1070 | |
| TLPTEELAYD | SVPAGEEEDE | EEDLGWGCPD | VAGTTRPTPP | PDLHNYMRRI | KDIA |