Q80WF4
Gene name |
Tmem132a (Gbp, Hspa5bp1) |
Protein name |
Transmembrane protein 132A |
Names |
GRP78-binding protein, HSPA5-binding protein 1 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:338474 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80WF4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80WF4-F1 | Predicted | AlphaFoldDB |
No variants for Q80WF4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q80WF4 | |||||
No associated diseases with Q80WF4
No regional properties for Q80WF4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q80WF4 | |||
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| cellular response to hydrogen peroxide | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
| negative regulation of programmed cell death | Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6IEE7 | TMEM132E | Transmembrane protein 132E | Homo sapiens (Human) | PR |
| Q14C87 | TMEM132D | Transmembrane protein 132D | Homo sapiens (Human) | PR |
| Q24JP5 | TMEM132A | Transmembrane protein 132A | Homo sapiens (Human) | PR |
| Q6IEE6 | Tmem132e | Transmembrane protein 132E | Mus musculus (Mouse) | PR |
| Q922P8 | Tmem132a | Transmembrane protein 132A | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTERAAAAPR | GPYGAWLCLL | VALALEVVRV | GSNQNTLDPI | YLPVALELLD | APEHFRVQQV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GHYPPANSSL | GSRSETFLLM | QPWPRAQPLL | RASYPPFATQ | QVVPPRVTEP | HRRPVPWDVR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AVSVEAAVTP | AEPYARVLFH | LKGQDWPPGP | GSLPCARLHA | THPAGTAHQA | CRFQPSLGAC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VVELQFPSQW | FSQSATTRAE | LAYTLEPAGE | GPGGCGPGTE | EEPKEQALPV | GSVELHPEDP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PQHQEVPLDE | VVTLRAPDVP | VRPGQLFTAT | LLLRHNFTAS | LLTLRIKVKK | GLQVTAARPA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QPTFWTAKLD | RFKGSKHHTS | LITCHRTGPA | GPDSRPLELP | EFLWVDFAVE | NSTGGGVAVT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RPVTWQLEYP | GQAPEAEKDK | MVWEILFSER | DIRALIPLAK | AEELVNTAPL | TGVPQRIPVR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LVTVDSGGAL | EEVTEHIGCE | SANTQVLQVS | EACDAVFVAG | QESRGAKGVR | VDFWWRRLRA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SLKLTVWAPL | LPLRIELTDT | TLEQIRGWRV | PGPAEGQLEP | EAAAEEVERR | SRGCRLQYQR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AGVRFLVPFA | AHPLDGGRRL | THLLGPDWLL | DVSHLVAAHA | HVQDPRIATL | EGGRILVGRE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PGVTSIEVRS | PLSDSILGEQ | ALAVTDDKVS | VLDLRVQPVM | GISLSLSRGV | SHPGEVTATC |
| 670 | 680 | 690 | 700 | 710 | 720 |
| WAQSALPAPK | QEVALSLWLS | FSDHTLAPAE | LYDRNDLGLS | VSAEEPSAVV | PAEEQRAQLG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VVVSGVGAKG | LPLHVALHPP | EPCRRGRHRV | PLASGTAWLG | LPPLPTPAPA | LPSSPARTPP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FTEASVEGKR | QVAGDMGSHV | GPGIRGKFER | AEEEAGKEEN | EAKEEEEDEE | EMVPAPQRVT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DLELGMYALL | GIFCLAFLIF | LVNGVVFVLR | YQRKEPPDSV | TDPASPQPHN | WVWLGTNQEE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LSRQLDRCSS | SSPPKGEGGC | PCESGAGGDT | STVAPSASES | PAGSTSTLAR | KEAGGRRKRV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| EFVTFAPAPP | AQEAPEEPVG | APAVQSILVA | GEEDIRWVCE | DMGLKDPEEL | RNYMERIRGS |
| S |