Q921T2

PR
Gene name
Tor1aip1
Protein name
Torsin-1A-interacting protein 1
Names
Lamina-associated polypeptide 1B, LAP1B
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:208263
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

98-186 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q921T2

Entry ID Method Resolution Chain Position Source
AF-Q921T2-F1 Predicted AlphaFoldDB

No variants for Q921T2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q921T2

No associated diseases with Q921T2

2 regional properties for Q921T2

Type Name Position InterPro Accession
domain Torsin-1A-interacting protein 1/2, AAA+ activator domain 366 - 595 IPR046753
domain Torsin-1A-interacting protein 1/2, N-terminal 143 - 361 IPR046754

Functions

Description
EC Number
Subcellular Localization
  • Nucleus inner membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear inner membrane The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATPase activator activity Binds to and increases the activity of an ATP hydrolysis activity.
ATPase binding Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
cytoskeletal protein binding Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
lamin binding Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope.

4 GO annotations of biological process

Name Definition
membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
nuclear membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane.
positive regulation of ATP-dependent activity Any process that activates or increases the rate of an ATP-dependent activity.
protein localization to nuclear envelope A process in which a protein is transported to, or maintained at, a location within a nuclear envelope.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8NFQ8 TOR1AIP2 Torsin-1A-interacting protein 2 Homo sapiens (Human) PR
Q5JTV8 TOR1AIP1 Torsin-1A-interacting protein 1 Homo sapiens (Human) PR
Q8BYU6 Tor1aip2 Torsin-1A-interacting protein 2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MAGERWQAEG PGEGWAIYVT PRAPIREGRR RLDPRNGDSS DAPAYGAHPS RRGRREVRFS
70 80 90 100 110 120
EEPAEVYGDF EPRAAKERSP GGRRTPPEKF RPASAGEEVR ESAYNLRSRP RRQRRAQEAE
130 140 150 160 170 180
EMKTRRSARL EQHSQQPQLS PATSGRGLRD SPSSSEDREE DEPSSRPVTS QTASKKTLRT
190 200 210 220 230 240
PEASVMNEDP ISNLCRPPLR SPRLDSTYQT NGNTKTNERE ATIVQQVNFF EEGETEDDLE
250 260 270 280 290 300
SSYSDITIRA RSSDSLESRD EATPAAGNHP DSLRGLPHNQ DFPAHENQPL LLTSGCQENP
310 320 330 340 350 360
QEWVDRAVRM RSRMAYNNIQ KSNFGNQSPS TSRPQSAIHH PNEPSVKIKW WLLGLVAILA
370 380 390 400 410 420
VGLFWFFHTP AVETTAVQEF QNQMKQLQSK YQSQNEKLWK RGTTFLEKHL NSSLPRPQPA
430 440 450 460 470 480
ILLLTAAQDA AEVLKCLSEQ IADAYSSFRS VRAIRIDGAG KAAQDSDLVK HEVDQELTDG
490 500 510 520 530 540
FKNGQNAAVV HRFESLPAGS TLIFYKYCDH ENAAFKDVAL VLTVLLEEKT LEASLGLKEI
550 560 570 580 590
EEKVRDFLKV KFTSSSTASS YNHMDPDKLN GLWSRISHLV LPVQPENTLK AGSCL