Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BYU6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BYU6-F1 | Predicted | AlphaFoldDB |
32 variants for Q8BYU6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388505475 | 17 | C>Y | No | EVA | |
| rs236852895 | 46 | N>D | No | EVA | |
| rs50888590 | 46 | N>S | No | EVA | |
| rs1133878116 | 48 | T>P | No | EVA | |
| rs265054605 | 53 | P>S | No | EVA | |
| rs3388509600 | 55 | Q>K | No | EVA | |
| rs49240126 | 56 | P>S | No | EVA | |
| rs47121208 | 82 | E>G | No | EVA | |
| rs47121208 | 82 | E>V | No | EVA | |
| rs3388506405 | 85 | E>* | No | EVA | |
| rs3390828981 | 102 | S>C | No | EVA | |
| rs3388509694 | 104 | S>N | No | EVA | |
| rs3390824119 | 112 | H>L | No | EVA | |
| rs51531165 | 119 | G>A | No | EVA | |
| rs258127775 | 121 | G>R | No | EVA | |
| rs51053223 | 130 | C>F | No | EVA | |
| rs47360418 | 134 | D>N | No | EVA | |
| rs3388510554 | 146 | S>N | No | EVA | |
| rs47321039 | 148 | V>A | No | EVA | |
| rs240610689 | 155 | G>C | No | EVA | |
| rs3410966546 | 160 | A>D | No | EVA | |
| rs51225423 | 161 | D>E | No | EVA | |
| rs3388504882 | 169 | A>P | No | EVA | |
| rs3388504894 | 190 | S>F | No | EVA | |
| rs3388508327 | 193 | G>S | No | EVA | |
| rs224925370 | 195 | S>N | No | EVA | |
| rs48369291 | 201 | T>A | No | EVA | |
| rs50171439 | 205 | N>S | No | EVA | |
| rs3388510547 | 323 | S>R | No | EVA | |
| rs31954062 | 366 | E>K | No | EVA | |
| rs3388507308 | 400 | E>G | No | EVA | |
| rs3390824088 | 449 | K>R | No | EVA |
No associated diseases with Q8BYU6
3 regional properties for Q8BYU6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Torsin-1A-interacting protein 1/2, AAA+ activator domain | 269 - 501 | IPR046753 |
| domain | Torsin-1A-interacting protein 1/2, N-terminal | 12 - 162 | IPR046754-1 |
| domain | Torsin-1A-interacting protein 1/2, N-terminal | 158 - 265 | IPR046754-2 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATPase activator activity | Binds to and increases the activity of an ATP hydrolysis activity. |
| ATPase binding | Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| endoplasmic reticulum organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. |
| membrane organization | A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. |
| positive regulation of ATP-dependent activity | Any process that activates or increases the rate of an ATP-dependent activity. |
| protein localization to nuclear envelope | A process in which a protein is transported to, or maintained at, a location within a nuclear envelope. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQSLKSQNT | NMSDSGCRDP | VGDSQNVLEN | DPSINSQTQD | TRVTPNNTAE | AQPLQPTSDL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KEDHHEIGAR | AQEHTDTGDR | SESPEEPALE | KPPLDKAELE | SSPSSQDTEL | GHHPHSEHGG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GDALDLDPNC | SQSDLGGRAD | AHLESSSVAS | PEGAGDRGEA | DEHLESSSAA | PTEGAGDRGE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AGQELLAEDS | TDGQSLGHSN | TGPGNQDSLR | RRLPVPEAGS | HEEETELVKE | KQEVAQDTLR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KTDKKSLWTY | GSVFLGCLIV | AVVLSSVNSY | YSSPAQQVPQ | NPALEAFLAQ | FGQLKEKFPG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QSSFLWQRGR | KFLQKHLNAS | NPSEPATIIF | TAAREGKETL | KCLSYHVANA | YTSSQKVTAV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SIDGAERALQ | DSDTVKLLVD | LELSDGFENG | HKAAVVHHFE | SLPAGSTLIF | YKYCDHENAA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FKDVALVLTV | LLEEETLEAS | VSPREIEEKV | RDLLWAKFTN | SESPTSYSHM | DSDKLSGLWS |
| 490 | 500 | ||||
| RISHLVLPVQ | PVRNIEERGC | LL |