Q91WB2

PR
Gene name
Plpp7
Protein name
Inactive phospholipid phosphatase 7
Names
Nuclear envelope transmembrane protein 39, Phosphatidic acid phosphatase type 2 domain-containing protein 3
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:227721
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-100 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q91WB2

Entry ID Method Resolution Chain Position Source
AF-Q91WB2-F1 Predicted AlphaFoldDB

10 variants for Q91WB2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388547209 78 K>R No EVA
rs3388544602 83 N>K No EVA
rs3388544195 109 A>V No EVA
rs3388544271 142 Q>H No EVA
rs3388542597 160 A>T No EVA
rs232736263 178 L>V No EVA
rs3388544219 192 G>S No EVA
rs3388543633 224 C>S No EVA
rs3388540357 262 N>S No EVA
rs3388546302 263 T>S No EVA

No associated diseases with Q91WB2

1 regional properties for Q91WB2

Type Name Position InterPro Accession
domain Phosphatidic acid phosphatase type 2/haloperoxidase 143 - 255 IPR000326

Functions

Description
EC Number
Subcellular Localization
  • Nucleus envelope
  • Endoplasmic reticulum membrane
  • Membrane; Multi-pass membrane protein
  • Both the N- and C-terminal are exposed to the cytoplasm/nucleoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

1 GO annotations of molecular function

Name Definition
sphingosine-1-phosphate phosphatase activity Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate.

1 GO annotations of biological process

Name Definition
negative regulation of myotube differentiation Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8NBV4 PLPP7 Inactive phospholipid phosphatase 7 Homo sapiens (Human) PR
Q5FVJ3 Plpp7 Inactive phospholipid phosphatase 7 Rattus norvegicus (Rat) PR
Q6P0E8 plpp7 Inactive phospholipid phosphatase 7 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MPASQSRARA RDRNNVLNRA EFLSLNQPPK GTQEPRSSGR KASGPSTQPP PSSDGARERR
70 80 90 100 110 120
QSQQLPEEDC MQLNPSFKGI AFNSLLAIDI CMSKRLGVCA GRAASWASAR SMVKLIGITG
130 140 150 160 170 180
HGIPWIGGTI LCLVRSSTLA GQEVLMNLLL ALLLDIMTVA GVQKLIKRRG PYETSPGLLD
190 200 210 220 230 240
YLTMDIYAFP AGHASRAAMV SKFFLSHLVL AVPLRVLLVL WAFCVGLSRV MIGRHHITDV
250 260 270
ISGFIIGYFQ FRLVELVWMS SNTCQMLISA W