Q5FVJ3

PR
Gene name
Plpp7
Protein name
Inactive phospholipid phosphatase 7
Names
Phosphatidic acid phosphatase type 2 domain-containing protein 3
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:296635
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-100 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5FVJ3

Entry ID Method Resolution Chain Position Source
AF-Q5FVJ3-F1 Predicted AlphaFoldDB

1 variants for Q5FVJ3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs199301353 3 V>A No EVA

No associated diseases with Q5FVJ3

1 regional properties for Q5FVJ3

Type Name Position InterPro Accession
domain Phosphatidic acid phosphatase type 2/haloperoxidase 143 - 255 IPR000326

Functions

Description
EC Number
Subcellular Localization
  • Nucleus envelope
  • Endoplasmic reticulum membrane
  • Membrane; Multi-pass membrane protein
  • Both the N- and C-terminal are exposed to the cytoplasm/nucleoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

1 GO annotations of molecular function

Name Definition
sphingosine-1-phosphate phosphatase activity Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate.

1 GO annotations of biological process

Name Definition
negative regulation of myotube differentiation Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8NBV4 PLPP7 Inactive phospholipid phosphatase 7 Homo sapiens (Human) PR
Q91WB2 Plpp7 Inactive phospholipid phosphatase 7 Mus musculus (Mouse) PR
Q6P0E8 plpp7 Inactive phospholipid phosphatase 7 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MPVSQSRARA RDRNNVLNRA EFLSLNQPPK GTQEPRSSGR KASGPSTQPP PSSDGARERR
70 80 90 100 110 120
QSQQLPEEDC MQLNPSFKGI AFNSLLAIDI CMSKRLGVCA GRAASWASAR SMVKLIGITS
130 140 150 160 170 180
HGIPWIGGTI LCLVRSSTLA GQEVLMNLLL ALLLDIMTVA GVQKLIKRRG PYETSPGLLD
190 200 210 220 230 240
YLTMDIYAFP AGHASRAAMV SKFFLSHLVL AVPLRVLLVL WAFCVGLSRV MIGRHHITDV
250 260 270
ISGFIIGYFQ FRLVELVWMS SNTCQMLISA W