Q6P0E8

PR
Gene name
plpp7
Protein name
Inactive phospholipid phosphatase 7
Names
Phosphatidic acid phosphatase type 2 domain-containing protein 3
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:402958
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-100 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6P0E8

Entry ID Method Resolution Chain Position Source
AF-Q6P0E8-F1 Predicted AlphaFoldDB

No variants for Q6P0E8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6P0E8

No associated diseases with Q6P0E8

1 regional properties for Q6P0E8

Type Name Position InterPro Accession
domain Phosphatidic acid phosphatase type 2/haloperoxidase 151 - 263 IPR000326

Functions

Description
EC Number
Subcellular Localization
  • Nucleus envelope
  • Endoplasmic reticulum membrane
  • Membrane; Multi-pass membrane protein
  • Both the N- and C-terminal are exposed to the cytoplasm/nucleoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

1 GO annotations of molecular function

Name Definition
sphingosine-1-phosphate phosphatase activity Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8NBV4 PLPP7 Inactive phospholipid phosphatase 7 Homo sapiens (Human) PR
Q91WB2 Plpp7 Inactive phospholipid phosphatase 7 Mus musculus (Mouse) PR
Q5FVJ3 Plpp7 Inactive phospholipid phosphatase 7 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MPANQTRSRA RERNNVLNRP EFMSLNQPIK SGGGGGGGES RGTARRPSQR QQQNQQQQGD
70 80 90 100 110 120
NPQPENNKDK KELPEEDCMQ LNPSFKGIAM NSLLAIDICM SKRLGVCAHP SSSWGSVRSM
130 140 150 160 170 180
VKLLALTGHG IPWVFGTIVC LMRSNTLAGQ EVLVNLLLAL LLDVMTVSGM QKLVKRKGPW
190 200 210 220 230 240
EMPPGFFDYL AMDIYSFPAA HASRAVMVSK FLLAHLVLAV PLRILLVLWA ILVGISRVLL
250 260 270 280
GRHHLTDVGC GFALGFLHYS LVEMVWLSSN TCQTLISIGT FNWSPLY