Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q8WUM9

Entry ID Method Resolution Chain Position Source
AF-Q8WUM9-F1 Predicted AlphaFoldDB

478 variants for Q8WUM9

Variant ID(s) Position Change Description Diseaes Association Provenance
CA348280395
rs1423236106
2 A>T Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA1835686
rs778228755
3 T>A No ClinGen
ExAC
gnomAD
rs1168090440
CA348280415
3 T>M No ClinGen
gnomAD
CA1835687
rs749743449
4 L>P No ClinGen
ExAC
gnomAD
CA348280446
rs1343553210
7 S>G No ClinGen
gnomAD
CA1835689
rs771575416
7 S>T No ClinGen
ExAC
gnomAD
CA348280461
rs1178350372
8 T>P No ClinGen
gnomAD
rs1278242011
CA348280469
8 T>S No ClinGen
gnomAD
rs779694210
CA1835690
9 T>A No ClinGen
ExAC
gnomAD
rs1212386264
CA348280481
9 T>I No ClinGen
gnomAD
rs1292485544
CA348280492
10 A>G No ClinGen
gnomAD
rs1335802515
CA348280501
11 A>G No ClinGen
TOPMed
rs1007199610
CA53666277
12 T>A No ClinGen
TOPMed
gnomAD
CA1835691
rs746581127
12 T>N No ClinGen
ExAC
gnomAD
CA348280536
rs1574177659
15 S>P No ClinGen
Ensembl
CA1835694
rs761561785
16 G>S No ClinGen
ExAC
gnomAD
rs1474559369
CA348280578
CA348280579
18 L>F No ClinGen
gnomAD
rs558248507
CA53666299
18 L>S No ClinGen
1000Genomes
CA1835696
rs773006725
19 V>G No ClinGen
ExAC
gnomAD
CA1835695
rs149661034
19 V>M No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA1835697
rs202070891
20 D>E No ClinGen
1000Genomes
ExAC
gnomAD
rs1425129478
CA348280600
20 D>G No ClinGen
gnomAD
CA1835698
rs766371866
22 L>V No ClinGen
ExAC
gnomAD
CA1835700
rs759584171
25 L>F No ClinGen
ExAC
gnomAD
rs377644769
CA1835702
26 I>V No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA348280703
rs1574177706
27 L>P No ClinGen
Ensembl
rs1245759647
CA348280717
29 F>L No ClinGen
gnomAD
CA1835704
rs764493271
31 I>V No ClinGen
ExAC
gnomAD
rs1021154291
CA53666403
34 V>G No ClinGen
TOPMed
CA348280832
rs1166739937
35 L>V No ClinGen
TOPMed
rs1217921423
CA348280848
36 A>T No ClinGen
gnomAD
CA53666408
rs780003002
37 F>L No ClinGen
Ensembl
rs1445418251
COSM714736
CA348280903
39 V>L lung [Cosmic] No ClinGen
cosmic curated
gnomAD
TCGA novel 41 A>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA348281029
rs1169491855
47 S>F No ClinGen
gnomAD
TCGA novel 53 G>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 56 V>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 57 V>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA348281161
rs1444205177
58 T>A No ClinGen
gnomAD
rs1193771536
CA348281178
59 L>V No ClinGen
TOPMed
rs1009014063
CA53666430
60 K>E Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
Ensembl
NCI-TCGA
CA1835707
rs779599521
62 A>G No ClinGen
ExAC
gnomAD
rs779599521
CA53666445
62 A>V No ClinGen
ExAC
gnomAD
CA53666469
rs900542424
64 I>V No ClinGen
Ensembl
CA1835708
rs534352386
65 L>Q No ClinGen
1000Genomes
ExAC
gnomAD
rs780760665
CA1835710
67 S>G No ClinGen
ExAC
gnomAD
CA1835712
rs769550112
71 T>I No ClinGen
ExAC
gnomAD
CA1835713
rs575071662
72 V>L No ClinGen
1000Genomes
ExAC
gnomAD
CA348281330
rs1451402840
74 S>P No ClinGen
gnomAD
CA1835714
rs749122077
75 V>A No ClinGen
ExAC
gnomAD
CA348281337
rs1335159740
75 V>F No ClinGen
gnomAD
TCGA novel 77 L>P Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs201375880
CA1835715
77 L>V No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1574177841
CA348281376
81 V>G No ClinGen
Ensembl
CA1835716
rs774223833
83 E>K No ClinGen
ExAC
gnomAD
CA348281394
rs1461053513
84 T>A No ClinGen
gnomAD
rs1364851062
CA348281403
85 I>M No ClinGen
gnomAD
CA1835717
rs139763523
85 I>V No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA348281412
rs1458976372
87 K>T No ClinGen
gnomAD
rs374197513
CA348281418
88 G>C No ClinGen
Ensembl
rs374197513
CA53666544
88 G>S No ClinGen
Ensembl
CA1835718
rs767428504
88 G>V No ClinGen
ExAC
TOPMed
gnomAD
rs775651843
CA1835719
89 L>S No ClinGen
ExAC
gnomAD
TCGA novel 92 V>L Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1468506744
CA348281442
92 V>M No ClinGen
gnomAD
rs146613177
CA1835720
93 E>K No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1429311044
CA348281457
94 M>L No ClinGen
TOPMed
gnomAD
CA348281476
rs1334363261
96 N>I No ClinGen
TOPMed
gnomAD
rs1402011123
CA348281478
96 N>K No ClinGen
gnomAD
CA348281475
rs1334363261
96 N>S No ClinGen
TOPMed
gnomAD
rs764474892
CA1835721
96 N>Y No ClinGen
ExAC
gnomAD
CA1835723
rs757741838
97 S>L No ClinGen
ExAC
TOPMed
gnomAD
CA1835722
rs754220323
97 S>P No ClinGen
ExAC
TOPMed
gnomAD
CA1835724
COSM4136116
rs765731739
99 Q>E ovary [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
rs1014651360
CA53666582
100 G>R No ClinGen
Ensembl
TCGA novel 100 G>W Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs199911692
CA53666595
103 M>V No ClinGen
TOPMed
gnomAD
rs916227171
CA53666598
104 A>S No ClinGen
gnomAD
CA348281519
rs916227171
104 A>T No ClinGen
gnomAD
rs1260300034
CA348281522
104 A>V No ClinGen
gnomAD
rs980288076
CA53666623
106 S>L No ClinGen
gnomAD
CA1835729
rs755692627
110 M>I No ClinGen
ExAC
gnomAD
CA348281559
rs1269513531
110 M>T No ClinGen
gnomAD
CA348281555
rs1200830967
110 M>V No ClinGen
gnomAD
rs777451974
CA1835730
111 F>I No ClinGen
ExAC
gnomAD
rs777295060
CA1835750
114 A>V No ClinGen
ExAC
gnomAD
rs753421218
CA1835751
116 W>C No ClinGen
ExAC
gnomAD
rs1247956785
CA348281638
120 A>V No ClinGen
gnomAD
CA1835755
rs771870685
122 F>L No ClinGen
ExAC
gnomAD
rs745739611
CA1835754
122 F>Y No ClinGen
ExAC
gnomAD
rs1485945264
CA348281678
126 P>L No ClinGen
gnomAD
rs746938555
CA1835757
127 I>V No ClinGen
ExAC
TOPMed
gnomAD
CA1835759
rs770231199
137 T>A No ClinGen
ExAC
TOPMed
gnomAD
CA348281754
rs1349437056
138 I>T No ClinGen
TOPMed
rs1384946288
CA348281750
138 I>V No ClinGen
gnomAD
rs1305034465
CA348281766
140 F>S No ClinGen
TOPMed
gnomAD
CA1835761
rs770211727
141 S>C No ClinGen
ExAC
gnomAD
rs770211727
CA348281774
141 S>F No ClinGen
ExAC
gnomAD
TCGA novel 142 L>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs763426663
CA1835763
143 V>L No ClinGen
ExAC
TOPMed
gnomAD
CA348281792
rs1287163637
145 K>E No ClinGen
TOPMed
gnomAD
CA348281794
rs1287163637
145 K>Q No ClinGen
TOPMed
gnomAD
CA1835764
rs41279744
145 K>R No ClinGen
1000Genomes
ExAC
gnomAD
TCGA novel 148 E>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1453593675
CA348281825
149 G>A No ClinGen
gnomAD
TCGA novel 149 G>C Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA1835765
rs191761952
151 K>R Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
1000Genomes
ExAC
NCI-TCGA
TOPMed
gnomAD
CA348281836
rs191761952
151 K>T No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA348281854
rs1377269719
153 S>F No ClinGen
TOPMed
COSM714735
CA1835766
rs760040356
154 E>Q lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] No ClinGen
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
CA1835767
rs763536324
156 I>T No ClinGen
ExAC
gnomAD
rs1309128747
CA348281882
158 I>V No ClinGen
gnomAD
rs1291200646
CA348282177
160 M>L No ClinGen
TOPMed
gnomAD
CA348282186
rs1175926992
160 M>T No ClinGen
gnomAD
CA1835786
rs774593041
161 S>A Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
CA348282234
rs1480836557
162 W>C No ClinGen
gnomAD
TCGA novel 165 S>P Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA53666977
rs774792166
166 P>Q No ClinGen
Ensembl
CA1835789
rs776084892
168 L>F No ClinGen
ExAC
TOPMed
gnomAD
CA348282353
rs776084892
168 L>V No ClinGen
ExAC
TOPMed
gnomAD
rs764671597
CA348282377
169 S>A No ClinGen
ExAC
TOPMed
gnomAD
rs764671597
CA1835791
169 S>T No ClinGen
ExAC
TOPMed
gnomAD
rs1347300489
CA348282422
171 I>S No ClinGen
gnomAD
rs750048519
CA1835792
172 M>T No ClinGen
ExAC
gnomAD
rs758004105
CA1835793
173 S>C No ClinGen
ExAC
rs1343283458
CA348282493
175 I>V No ClinGen
gnomAD
TCGA novel 181 R>C Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs766187428
CA1835794
181 R>G No ClinGen
ExAC
gnomAD
CA348282605
COSM714734
rs1451742197
181 R>H lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] No ClinGen
cosmic curated
NCI-TCGA
TOPMed
gnomAD
CA348282620
rs1574178485
182 A>V No ClinGen
Ensembl
rs751469137
CA1835795
183 F>V No ClinGen
ExAC
gnomAD
rs369254653
CA1835797
184 I>V No ClinGen
ESP
ExAC
TOPMed
gnomAD
TCGA novel 186 H>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA1835798
rs748120528
186 H>Y Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs1438821429
CA348282695
187 K>N No ClinGen
TOPMed
rs746108215
CA1835823
188 A>G No ClinGen
ExAC
TOPMed
gnomAD
rs891836701
CA53658422
188 A>T No ClinGen
Ensembl
CA1835824
rs746108215
188 A>V No ClinGen
ExAC
TOPMed
gnomAD
rs780397456
CA1835825
189 D>A No ClinGen
ExAC
gnomAD
CA1835826
rs747540640
189 D>E No ClinGen
ExAC
TOPMed
gnomAD
CA348279416
rs1343518651
191 V>L No ClinGen
TOPMed
CA1835827
rs769113530
192 P>A No ClinGen
ExAC
gnomAD
TCGA novel 192 P>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs772749728
CA1835828
197 A>V No ClinGen
ExAC
gnomAD
CA1835829
rs762422707
200 V>A No ClinGen
ExAC
rs1158275445
CA348279544
202 Y>C No ClinGen
TOPMed
rs535912709
CA348279551
203 A>P No ClinGen
1000Genomes
ExAC
gnomAD
rs535912709
CA1835830
203 A>T No ClinGen
1000Genomes
ExAC
gnomAD
CA348279556
rs1245694306
203 A>V No ClinGen
gnomAD
TCGA novel 204 C>F Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs774108947
CA1835831
204 C>W No ClinGen
ExAC
gnomAD
rs1420607728
CA348279581
205 T>I No ClinGen
TOPMed
rs773074656
CA1835832
206 V>L No ClinGen
ExAC
TOPMed
gnomAD
CA1835833
rs767364132
207 G>E No ClinGen
ExAC
gnomAD
rs752597232
CA1835834
208 I>T No ClinGen
ExAC
TOPMed
gnomAD
rs759441522
CA53658462
210 L>V No ClinGen
TOPMed
gnomAD
rs763976774
CA1835836
211 F>S No ClinGen
ExAC
gnomAD
TCGA novel 212 S>F Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1184127607
CA348279678
214 M>T No ClinGen
TOPMed
CA53658468
rs201514397
214 M>V Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA1835837
rs753931777
215 Y>C No ClinGen
ExAC
gnomAD
TCGA novel 215 Y>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA348279724
rs555852623
217 G>A No ClinGen
1000Genomes
gnomAD
CA53658479
rs555852623
217 G>E No ClinGen
1000Genomes
gnomAD
CA1835840
rs760415578
219 P>L No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 221 L>= Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA348280739
rs1204114682
222 G>D No ClinGen
gnomAD
CA1835890
rs746582790
225 K>R No ClinGen
ExAC
TOPMed
gnomAD
CA1835891
rs367664642
226 L>P No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1161392345
CA348280846
228 L>P No ClinGen
gnomAD
rs371185107
CA1835892
229 W>C No ClinGen
ESP
ExAC
TOPMed
rs1574187373
CA348280864
229 W>L No ClinGen
Ensembl
CA1835893
rs373737331
232 I>T No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1574187391
CA348280925
233 L>P No ClinGen
Ensembl
CA53661779
rs915647967
233 L>V No ClinGen
TOPMed
gnomAD
rs968478367
CA53661785
234 I>N No ClinGen
TOPMed
gnomAD
CA1835894
rs367940908
235 S>L No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs367940908
CA348280954
235 S>W No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1337107177
CA348280958
236 V>M No ClinGen
gnomAD
rs1558693687
CA348281000
239 A>S No ClinGen
Ensembl
CA348281007
rs1308521579
239 A>V No ClinGen
gnomAD
rs774549910
CA348281055
COSM418614
243 A>S Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
gnomAD
rs774549910
CA1835899
243 A>T Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs1184282093
CA348281082
245 I>T No ClinGen
TOPMed
CA348281089
rs753087768
246 V>F No ClinGen
ExAC
TOPMed
gnomAD
rs753087768
CA1835902
246 V>I No ClinGen
ExAC
TOPMed
gnomAD
rs753087768
CA348281088
246 V>L Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
CA348281102
rs1482565868
TCGA novel
247 W>* Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
gnomAD
NCI-TCGA
CA1835903
rs756497809
248 F>L No ClinGen
ExAC
gnomAD
TCGA novel 250 V>L Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA348281199
rs1253881123
254 M>R No ClinGen
gnomAD
rs935537199
CA53661862
255 K>R No ClinGen
Ensembl
rs764583377
CA1835904
256 R>G No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 256 R>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA348281224
rs1418630397
256 R>T No ClinGen
gnomAD
rs1431764688
CA348281273
260 R>* Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
gnomAD
rs762218609
CA1835931
261 E>G No ClinGen
ExAC
CA348282023
rs1574188924
264 C>G No ClinGen
Ensembl
CA348282030
rs1574188939
264 C>W No ClinGen
Ensembl
rs1443545123
CA348282034
265 S>G No ClinGen
TOPMed
rs765825896
CA1835932
265 S>N No ClinGen
ExAC
gnomAD
CA348282052
rs1574188949
266 P>L No ClinGen
Ensembl
CA348282063
rs1574188952
267 S>F No ClinGen
Ensembl
CA53663117
rs878874905
272 M>L No ClinGen
Ensembl
rs750918259
CA1835933
272 M>R No ClinGen
ExAC
TCGA novel 276 N>E Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs752290078
CA1835936
277 S>I No ClinGen
ExAC
gnomAD
rs1408556376
CA348282318
282 H>D No ClinGen
gnomAD
rs777541851
CA1835938
282 H>R No ClinGen
ExAC
gnomAD
CA1835939
rs201347526
283 E>K No ClinGen
1000Genomes
ExAC
gnomAD
CA348282358
rs1331538071
283 E>V No ClinGen
gnomAD
CA348282425
rs1166706631
286 K>T No ClinGen
gnomAD
CA348282471
rs1189240775
288 S>C No ClinGen
TOPMed
rs770750611
CA1835940
289 V>F No ClinGen
ExAC
gnomAD
rs778859962
CA1835941
292 I>T No ClinGen
ExAC
gnomAD
CA53663212
rs926838863
293 E>G No ClinGen
TOPMed
rs200685704
CA53663218
294 N>K No ClinGen
1000Genomes
CA348282578
rs1260721885
294 N>S No ClinGen
TOPMed
CA53663220
rs202157771
295 K>M No ClinGen
Ensembl
rs772122673
CA1835944
298 V>A No ClinGen
ExAC
gnomAD
CA348282690
rs1365003831
299 S>F No ClinGen
gnomAD
rs1282047892
CA348282703
300 E>V No ClinGen
gnomAD
CA348282712
rs1433325776
301 V>E No ClinGen
gnomAD
CA348282727
rs1360753679
303 P>H No ClinGen
TOPMed
gnomAD
rs372292907
CA1835946
306 V>M No ClinGen
ESP
ExAC
gnomAD
rs1014541509
CA53663235
307 P>R No ClinGen
Ensembl
rs777116177
COSM134036
CA1835948
308 L>F skin [Cosmic] No ClinGen
cosmic curated
ExAC
gnomAD
CA1835950
rs762192682
309 Q>* No ClinGen
ExAC
gnomAD
rs762192682
CA1835949
309 Q>K No ClinGen
ExAC
gnomAD
rs149823520
CA53663283
309 Q>L No ClinGen
ESP
TOPMed
gnomAD
CA1835951
rs750880631
310 A>S No ClinGen
ExAC
gnomAD
rs763384310
CA1835952
311 V>A No ClinGen
ExAC
gnomAD
CA348282863
rs1473059329
315 R>* No ClinGen
gnomAD
CA348282882
rs1180790661
316 T>R No ClinGen
gnomAD
rs1401929976
CA348282895
317 V>G No ClinGen
gnomAD
CA348282886
rs1410906786
317 V>I No ClinGen
gnomAD
CA348282888
rs1410906786
317 V>L No ClinGen
gnomAD
CA1835954
rs752271980
321 L>P No ClinGen
ExAC
gnomAD
rs755734378
CA1835955
323 D>V No ClinGen
ExAC
gnomAD
rs1001597756
CA348282941
324 L>S No ClinGen
TOPMed
CA53663306
rs1001597756
324 L>W No ClinGen
TOPMed
CA348282981
rs1339057740
327 A>T No ClinGen
gnomAD
CA53663317
rs1033109842
329 E>A No ClinGen
Ensembl
rs1296654092
CA348283032
330 R>S No ClinGen
TOPMed
CA348283037
rs1282505424
331 E>Q No ClinGen
gnomAD
CA1835957
rs763783121
333 L>F No ClinGen
ExAC
gnomAD
rs763783121
CA1835958
333 L>I No ClinGen
ExAC
gnomAD
rs757036701
CA1835959
334 P>R No ClinGen
ExAC
gnomAD
CA53663340
rs957463473
334 P>S No ClinGen
Ensembl
CA1835960
rs778577340
335 S>G No ClinGen
ExAC
gnomAD
CA348283090
rs778577340
335 S>R No ClinGen
ExAC
gnomAD
rs1574189250
CA348283113
336 V>G No ClinGen
Ensembl
CA1835962
rs758464142
336 V>M No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 336 V>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1574189259
CA348283120
337 D>G No ClinGen
Ensembl
rs543798918
CA1835964
338 L>V No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA53663409
rs377303577
340 E>D No ClinGen
ESP
TOPMed
gnomAD
CA348283153
rs1574189281
340 E>K No ClinGen
Ensembl
CA348283213
rs1470904653
344 I>M No ClinGen
gnomAD
CA1835966
rs373019890
344 I>V No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA348283221
rs1182233898
345 D>G No ClinGen
gnomAD
rs1372209370
CA348283229
346 S>C No ClinGen
TOPMed
CA348283247
rs1471378708
347 T>I No ClinGen
gnomAD
rs770142025
CA348283250
348 V>L No ClinGen
ExAC
TOPMed
gnomAD
CA1835968
rs770142025
348 V>M No ClinGen
ExAC
TOPMed
gnomAD
rs369199442
CA53663434
350 G>S No ClinGen
ESP
TOPMed
gnomAD
RCV000879799
CA1835983
rs113994840
351 A>T No ClinGen
ClinVar
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
CA53663542
rs968178606
351 A>V No ClinGen
TOPMed
gnomAD
TCGA novel 352 V>L Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs201256222
CA1835985
355 P>L No ClinGen
ExAC
TOPMed
gnomAD
rs748388833
CA1835986
COSM3961000
356 N>D lung [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
rs1307502502
CA348283377
356 N>K No ClinGen
gnomAD
rs1175459427
CA348283391
358 N>H No ClinGen
TOPMed
TCGA novel 358 N>P Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA1835987
rs769977611
359 L>F No ClinGen
ExAC
gnomAD
rs1558694904
CA348283433
361 Q>L No ClinGen
Ensembl
TCGA novel 361 Q>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 365 A>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1478277333
CA348283471
365 A>T No ClinGen
TOPMed
CA1835990
rs147673696
366 V>I No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA1835991
rs774798698
367 S>G No ClinGen
ExAC
gnomAD
CA1835992
rs760040431
369 Q>H No ClinGen
ExAC
TOPMed
gnomAD
CA348283518
rs1437369649
370 I>R No ClinGen
TOPMed
CA1835993
rs373453790
371 N>K No ClinGen
ESP
ExAC
gnomAD
rs1574189516
CA348283528
371 N>T No ClinGen
Ensembl
rs1273822472
CA348283539
372 S>Y No ClinGen
gnomAD
rs1238991594
CA348283549
373 S>G No ClinGen
TOPMed
rs1267649484
CA348283570
374 G>V No ClinGen
gnomAD
rs1302004354
CA348283582
375 H>R No ClinGen
TOPMed
gnomAD
CA1835996
rs764835023
377 Q>H No ClinGen
ExAC
gnomAD
rs1450471766
CA348283646
381 V>L No ClinGen
TOPMed
gnomAD
CA348283648
rs1450471766
381 V>M No ClinGen
TOPMed
gnomAD
CA53663652
rs917601016
382 H>R No ClinGen
Ensembl
CA348283659
rs1224576423
382 H>Y No ClinGen
TOPMed
CA1836002
rs781328277
387 L>P No ClinGen
ExAC
gnomAD
CA348283722
rs781328277
387 L>Q No ClinGen
ExAC
gnomAD
TCGA novel 388 Y>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 391 L>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 394 K>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA1836003
rs752761194
396 H>Y No ClinGen
ExAC
gnomAD
CA1836005
rs777811940
403 C>G No ClinGen
ExAC
gnomAD
TCGA novel 404 M>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA348283891
rs1325463690
404 M>V No ClinGen
gnomAD
CA348283902
rs1435527762
405 G>E No ClinGen
gnomAD
CA1836007
rs140855509
408 G>S No ClinGen
ESP
ExAC
rs779262246
CA1836008
409 D>N No ClinGen
ExAC
TOPMed
gnomAD
CA348283944
rs1246376084
411 P>L No ClinGen
gnomAD
CA1836010
rs772517584
414 R>C No ClinGen
ExAC
TOPMed
gnomAD
CA348283965
rs1335835565
415 N>D No ClinGen
TOPMed
CA348283969
rs1414886098
415 N>I No ClinGen
TOPMed
rs776173052
CA1836011
416 N>T No ClinGen
ExAC
gnomAD
rs1285893818
CA348284001
420 S>T No ClinGen
gnomAD
rs761275979
CA1836012
423 M>V No ClinGen
ExAC
gnomAD
CA1836014
rs772676810
425 I>M No ClinGen
ExAC
gnomAD
CA348284042
rs1156786091
426 C>S No ClinGen
TOPMed
CA348284044
rs1188353298
426 C>Y No ClinGen
gnomAD
rs1469595033
CA348284061
428 M>I No ClinGen
TOPMed
rs1367898949
CA348284066
429 P>S No ClinGen
gnomAD
rs546806589
CA1836015
431 D>H No ClinGen
ExAC
gnomAD
rs1342789139
CA348284092
433 F>S No ClinGen
gnomAD
rs371323488
CA1836016
COSM1226010
434 R>C large_intestine [Cosmic] No ClinGen
cosmic curated
ESP
ExAC
TOPMed
gnomAD
CA1836017
rs751466959
434 R>H Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1457600022
CA348284110
436 K>R No ClinGen
TOPMed
gnomAD
CA1836018
rs759515767
438 G>C No ClinGen
ExAC
gnomAD
CA348284122
rs759515767
438 G>S No ClinGen
ExAC
gnomAD
rs7591371
CA53663793
441 K>T No ClinGen
Ensembl
CA53663801
rs540684988
442 G>D No ClinGen
TOPMed
rs1242821259
CA348284150
442 G>S No ClinGen
TOPMed
CA348284154
rs540684988
442 G>V No ClinGen
TOPMed
CA1836020
rs752704524
443 E>K No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 444 E>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs756104481
CA1836021
444 E>D No ClinGen
ExAC
TOPMed
gnomAD
rs754000202
CA1836023
448 L>P No ClinGen
ExAC
gnomAD
CA53663880
rs1048833347
453 A>V No ClinGen
TOPMed
CA1836025
rs779241578
456 K>R No ClinGen
ExAC
TOPMed
gnomAD
CA53663885
rs779241578
456 K>T No ClinGen
ExAC
TOPMed
gnomAD
CA348284254
rs1380106255
457 K>E No ClinGen
TOPMed
CA1836026
rs746267668
458 R>* No ClinGen
ExAC
gnomAD
CA348284262
rs1190917458
458 R>Q No ClinGen
gnomAD
COSM3425117
CA1836027
rs772606473
460 R>Q Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
gnomAD
CA348284313
rs1448444654
465 T>S No ClinGen
TOPMed
rs1256053493
CA348284333
468 C>G No ClinGen
gnomAD
rs199972774
CA1836029
469 N>D No ClinGen
1000Genomes
ExAC
gnomAD
rs769131606
CA1836030
469 N>S No ClinGen
ExAC
gnomAD
CA348284352
rs772919182
471 V>L No ClinGen
ExAC
TOPMed
gnomAD
CA1836031
rs772919182
471 V>M No ClinGen
ExAC
TOPMed
gnomAD
CA1836032
rs137900126
472 S>C No ClinGen
ESP
ExAC
TOPMed
gnomAD
TCGA novel 473 D>A Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs878944586
CA348284367
473 D>E No ClinGen
TOPMed
gnomAD
CA53663961
rs1020665246
474 L>P No ClinGen
Ensembl
rs1467374198
CA348284378
475 H>R No ClinGen
gnomAD
rs1574189882
CA348284376
475 H>Y No ClinGen
Ensembl
CA348284414
rs1393828749
480 I>M No ClinGen
gnomAD
rs1459036968
CA348284424
482 M>V No ClinGen
TOPMed
gnomAD
CA1836034
rs774266731
483 S>N No ClinGen
ExAC
TOPMed
gnomAD
rs759204105
CA1836035
483 S>R No ClinGen
ExAC
gnomAD
CA1836033
rs770747583
483 S>R No ClinGen
ExAC
gnomAD
CA348284442
rs1314367967
484 V>G No ClinGen
gnomAD
rs1286067913
CA348284438
484 V>I No ClinGen
gnomAD
CA348284451
rs1384805943
486 A>T No ClinGen
TOPMed
CA348284463
rs1234395946
487 E>D No ClinGen
gnomAD
CA1836036
rs767378891
488 M>R No ClinGen
ExAC
gnomAD
CA1836037
rs767378891
488 M>T No ClinGen
ExAC
gnomAD
TCGA novel 493 R>G Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1163282318
CA348284502
493 R>S No ClinGen
gnomAD
CA53663997
rs867440109
494 K>R No ClinGen
Ensembl
CA1836039
rs764066750
495 G>R No ClinGen
ExAC
TOPMed
gnomAD
CA53664026
rs202246554
496 S>G No ClinGen
1000Genomes
CA348284521
rs1180362659
496 S>R No ClinGen
gnomAD
rs1488901146
CA348284533
498 G>S No ClinGen
TOPMed
CA1836040
rs753981077
498 G>V No ClinGen
ExAC
gnomAD
CA348284541
rs1288855746
499 S>F No ClinGen
TOPMed
CA1836041
rs757438670
500 L>V No ClinGen
ExAC
TOPMed
gnomAD
rs376330319
CA1836043
504 Y>C No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs1322313113
CA348284592
506 Q>H No ClinGen
TOPMed
gnomAD
CA53664098
rs776031460
506 Q>K No ClinGen
gnomAD
CA1836045
rs780482482
507 D>Y No ClinGen
ExAC
gnomAD
rs747459559
CA1836046
509 P>S No ClinGen
ExAC
CA348284630
rs1305849584
512 S>C No ClinGen
TOPMed
gnomAD
CA53664106
rs201196105
512 S>P No ClinGen
1000Genomes
rs1300949589
CA348284654
516 Q>* No ClinGen
gnomAD
CA348284662
rs1310958992
517 F>V No ClinGen
gnomAD
rs1341603040
CA348284715
525 F>L No ClinGen
gnomAD
TCGA novel 529 A>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA1836052
rs745537163
530 H>R No ClinGen
ExAC
gnomAD
CA348284768
rs1170477021
533 N>H No ClinGen
gnomAD
CA348284772
rs1390688770
533 N>S No ClinGen
TOPMed
gnomAD
rs142437239
COSM3406791
CA1836056
535 V>I ovary Variant assessed as Somatic; 0.0 impact. central_nervous_system [Cosmic, NCI-TCGA] No ClinGen
cosmic curated
ESP
ExAC
NCI-TCGA
gnomAD
rs1322024978
CA348285421
537 N>S No ClinGen
TOPMed
CA348285444
rs1574190664
538 A>V No ClinGen
Ensembl
rs773409353
CA1836078
539 I>T No ClinGen
ExAC
TOPMed
gnomAD
rs1231857122
CA348285449
539 I>V No ClinGen
TOPMed
TCGA novel 540 G>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs763055033
CA1836080
541 P>L No ClinGen
ExAC
gnomAD
CA348285526
rs1464267721
545 L>I No ClinGen
gnomAD
CA348285585
rs1239105437
549 Y>C No ClinGen
gnomAD
CA1836083
rs759943275
552 G>E No ClinGen
ExAC
gnomAD
rs1574190712
CA348285639
554 V>L No ClinGen
Ensembl
rs377665017
CA1836085
559 A>P No ClinGen
ExAC
TOPMed
gnomAD
rs377665017
CA1836084
559 A>S No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 559 A>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1399169809
CA348285719
560 T>A No ClinGen
TOPMed
CA53664638
rs182187263
560 T>I No ClinGen
1000Genomes
ExAC
gnomAD
CA1836086
rs182187263
560 T>R No ClinGen
1000Genomes
ExAC
gnomAD
CA348285745
rs749985118
562 I>L No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 562 I>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA1836088
rs749985118
562 I>V No ClinGen
ExAC
TOPMed
gnomAD
rs1574190744
CA348285781
564 L>F No ClinGen
Ensembl
rs1336774385
CA348285807
566 L>F No ClinGen
gnomAD
rs1336774385
CA348285803
566 L>I No ClinGen
gnomAD
CA348285810
rs1360222173
566 L>P Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
rs147689740
CA1836092
567 Y>C No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA1836093
rs781024720
570 V>G No ClinGen
ExAC
gnomAD
CA348285885
rs1229313190
571 G>V No ClinGen
gnomAD
rs748074438
CA348285913
573 C>F No ClinGen
ExAC
gnomAD
CA1836094
rs748074438
573 C>S No ClinGen
ExAC
gnomAD
rs773142769
CA1836096
578 V>F No ClinGen
ExAC
TOPMed
gnomAD
rs1574190820
CA348286009
578 V>G No ClinGen
Ensembl
rs773142769
CA348286007
578 V>L No ClinGen
ExAC
TOPMed
gnomAD
CA348286032
rs1379375745
579 W>C No ClinGen
TOPMed
rs1442880575
CA348286075
582 R>K No ClinGen
gnomAD
TCGA novel 590 D>E Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
COSM1005608
rs1050491233
CA53664670
593 P>L Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
Ensembl
NCI-TCGA
rs774570059
CA1836099
594 I>V No ClinGen
ExAC
TOPMed
gnomAD
CA1836100
rs759853632
595 T>I No ClinGen
ExAC
gnomAD
CA348286391
rs1388871873
598 S>T No ClinGen
gnomAD
rs1230271139
CA348286519
599 G>D No ClinGen
gnomAD
rs201598485
CA53665349
600 F>L No ClinGen
ExAC
gnomAD
rs1477896604
CA348286552
601 S>G Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
rs1172368198
CA348286578
602 I>F No ClinGen
gnomAD
CA348286586
rs1574191449
603 E>* No ClinGen
Ensembl
rs1430515211
CA348286658
607 A>S No ClinGen
gnomAD
rs749190745
CA1836118
608 L>F No ClinGen
ExAC
gnomAD
rs977865531
CA53665377
608 L>R No ClinGen
TOPMed
rs770988125
CA1836119
610 V>L No ClinGen
ExAC
gnomAD
CA348286750
rs1331530156
612 I>M No ClinGen
TOPMed
gnomAD
rs552104775
CA1836120
612 I>T No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1436100089
CA348286760
613 A>V No ClinGen
TOPMed
CA348286781
rs1377976921
614 S>L No ClinGen
TOPMed
rs760782418
CA53665403
616 I>S Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
Ensembl
NCI-TCGA
CA348286805
rs1177581519
616 I>V No ClinGen
TOPMed
rs1252338070
CA348286896
621 S>G No ClinGen
TOPMed
CA348287561
rs1195784160
627 V>M No ClinGen
gnomAD
CA348287575
rs1425680604
628 G>D No ClinGen
gnomAD
rs1190508814
CA348287588
629 S>C No ClinGen
TOPMed
rs769004651
CA1836145
635 W>C No ClinGen
ExAC
TOPMed
gnomAD
rs776917100
CA1836146
636 L>P No ClinGen
ExAC
gnomAD
rs891087521
CA53666821
637 R>Q No ClinGen
TOPMed
COSM3670292
rs762352158
CA1836147
637 R>W Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
CA348287661
rs1574192959
638 S>A No ClinGen
Ensembl
CA53666824
rs553216163
638 S>C No ClinGen
1000Genomes
CA53666831
rs140743522
639 K>E No ClinGen
ESP
TCGA novel 639 K>M Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA348287678
rs1381339408
640 K>E No ClinGen
TOPMed
TCGA novel 641 A>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1268505591
CA348287731
644 W>* No ClinGen
TOPMed
rs752292041
CA1836152
645 R>C Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
CA348287740
rs1334175844
645 R>H Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
gnomAD
CA348287764
rs1354430466
647 F>L No ClinGen
gnomAD
CA348287770
rs1320654253
648 R>C No ClinGen
TOPMed
rs755784156
COSM164364
CA1836153
648 R>H Variant assessed as Somatic; 4.619e-05 impact. breast [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
gnomAD
TCGA novel 649 N>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs763942880
CA1836154
652 M>I No ClinGen
ExAC
gnomAD
rs998862364
CA53666873
658 V>I No ClinGen
TOPMed
gnomAD
rs1053164629
CA53666877
660 I>V No ClinGen
TOPMed
rs1183681952
CA348287929
663 V>I No ClinGen
gnomAD
rs145135006
CA1836157
664 I>T No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA1836156
rs572931531
664 I>V No ClinGen
1000Genomes
ExAC
gnomAD
CA53666887
rs1052406229
666 A>V No ClinGen
Ensembl
CA53666890
rs891144402
667 A>V No ClinGen
gnomAD
CA348287977
rs1484730537
668 I>V No ClinGen
gnomAD
CA1836158
rs151199405
671 I>V No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs758486316
CA1836159
672 F>L No ClinGen
ExAC
gnomAD
CA1836160
rs780293278
675 V>D No ClinGen
ExAC
gnomAD
rs1158040820
CA348288104
676 I>V No ClinGen
gnomAD
rs1242385543
CA348288143
678 R>S No ClinGen
TOPMed
rs1362004058
CA348288151
679 M>K No ClinGen
gnomAD
CA348288162
rs1190133042
680 M>R No ClinGen
TOPMed

No associated diseases with Q8WUM9

No regional properties for Q8WUM9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8WUM9

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
high-affinity inorganic phosphate:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
inorganic phosphate transmembrane transporter activity Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
signaling receptor activity Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
sodium:phosphate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in).

5 GO annotations of biological process

Name Definition
biomineral tissue development Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation.
ion transport The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
phosphate ion transmembrane transport The process in which a phosphate is transported across a membrane.
phosphate-containing compound metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.
positive regulation of I-kappaB kinase/NF-kappaB signaling Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q95L97 SLC20A2 Sodium-dependent phosphate transporter 2 Felis catus (Cat) (Felis silvestris catus) PR
O97596 Slc20a1 Sodium-dependent phosphate transporter 1 Felis catus (Cat) (Felis silvestris catus) PR
Q08357 SLC20A2 Sodium-dependent phosphate transporter 2 Homo sapiens (Human) PR
Q61609 Slc20a1 Sodium-dependent phosphate transporter 1 Mus musculus (Mouse) PR
Q5BL44 slc20a1 Sodium-dependent phosphate transporter 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MATLITSTTA ATAASGPLVD YLWMLILGFI IAFVLAFSVG ANDVANSFGT AVGSGVVTLK
70 80 90 100 110 120
QACILASIFE TVGSVLLGAK VSETIRKGLI DVEMYNSTQG LLMAGSVSAM FGSAVWQLVA
130 140 150 160 170 180
SFLKLPISGT HCIVGATIGF SLVAKGQEGV KWSELIKIVM SWFVSPLLSG IMSGILFFLV
190 200 210 220 230 240
RAFILHKADP VPNGLRALPV FYACTVGINL FSIMYTGAPL LGFDKLPLWG TILISVGCAV
250 260 270 280 290 300
FCALIVWFFV CPRMKRKIER EIKCSPSESP LMEKKNSLKE DHEETKLSVG DIENKHPVSE
310 320 330 340 350 360
VGPATVPLQA VVEERTVSFK LGDLEEAPER ERLPSVDLKE ETSIDSTVNG AVQLPNGNLV
370 380 390 400 410 420
QFSQAVSNQI NSSGHYQYHT VHKDSGLYKE LLHKLHLAKV GDCMGDSGDK PLRRNNSYTS
430 440 450 460 470 480
YTMAICGMPL DSFRAKEGEQ KGEEMEKLTW PNADSKKRIR MDSYTSYCNA VSDLHSASEI
490 500 510 520 530 540
DMSVKAEMGL GDRKGSNGSL EEWYDQDKPE VSLLFQFLQI LTACFGSFAH GGNDVSNAIG
550 560 570 580 590 600
PLVALYLVYD TGDVSSKVAT PIWLLLYGGV GICVGLWVWG RRVIQTMGKD LTPITPSSGF
610 620 630 640 650 660
SIELASALTV VIASNIGLPI STTHCKVGSV VSVGWLRSKK AVDWRLFRNI FMAWFVTVPI
670
SGVISAAIMA IFRYVILRM