Q61609
Gene name |
Slc20a1 (Glvr1, Pit1) |
Protein name |
Sodium-dependent phosphate transporter 1 |
Names |
Gibbon ape leukemia virus receptor 1, GLVR-1, Leukemia virus receptor 1 homolog, Phosphate transporter 1, PiT-1, Solute carrier family 20 member 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20515 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q61609
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q61609-F1 | Predicted | AlphaFoldDB |
16 variants for Q61609
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs27433473 | 101 | E>K | No | EVA | |
| rs27433472 | 103 | Q>R | No | EVA | |
| rs3388586223 | 120 | W>* | No | EVA | |
| rs27433446 | 336 | R>W | No | EVA | |
| rs3388592740 | 369 | V>I | No | EVA | |
| rs3388592576 | 394 | L>R | No | EVA | |
| rs3388593996 | 422 | T>N | No | EVA | |
| rs3388577447 | 497 | K>E | No | EVA | |
| rs3388585086 | 500 | S>C | No | EVA | |
| rs27433443 | 500 | S>N | No | EVA | |
| rs27433442 | 507 | Y>C | No | EVA | |
| rs3388586199 | 542 | I>N | No | EVA | |
| rs3388586176 | 622 | I>S | No | EVA | |
| rs3388590397 | 644 | V>I | No | EVA | |
| rs3388590114 | 679 | L>V | No | EVA | |
| rs3388590442 | 680 | P>Q | No | EVA |
No associated diseases with Q61609
1 regional properties for Q61609
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Major facilitator superfamily domain | 320 - 539 | IPR020846 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| high-affinity inorganic phosphate:sodium symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. |
| inorganic phosphate transmembrane transporter activity | Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| biomineral tissue development | Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. |
| phosphate ion transmembrane transport | The process in which a phosphate is transported across a membrane. |
| phosphate ion transport | The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q95L97 | SLC20A2 | Sodium-dependent phosphate transporter 2 | Felis catus (Cat) (Felis silvestris catus) | PR |
| O97596 | Slc20a1 | Sodium-dependent phosphate transporter 1 | Felis catus (Cat) (Felis silvestris catus) | PR |
| Q08357 | SLC20A2 | Sodium-dependent phosphate transporter 2 | Homo sapiens (Human) | PR |
| Q8WUM9 | SLC20A1 | Sodium-dependent phosphate transporter 1 | Homo sapiens (Human) | PR |
| Q5BL44 | slc20a1 | Sodium-dependent phosphate transporter 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESTVATITS | TLAAVTASAP | PKYDNLWMLI | LGFIIAFVLA | FSVGANDVAN | SFGTAVGSGV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VTLKQACILA | SIFETVGSAL | LGAKVSETIR | NGLIDVELYN | ETQDLLMAGS | VSAMFGSAVW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QLVASFLKLP | ISGTHCIVGA | TIGFSLVANG | QKGVKWSELI | KIVMSWFVSP | LLSGIMSGIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FFLVRAFILR | KADPVPNGLR | ALPIFYACTI | GINLFSIMYT | GAPLLGFDKL | PLWGTILISV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GCAVFCALIV | WFFVCPRMKR | KIEREVKSSP | SESPLMEKKS | NLKEDHEETK | MAPGDVEHRN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PVSEVVCATG | PLRAVVEERT | VSFKLGDLEE | APERERLPMD | LKEETSIDST | INGAVQLPNG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NLVQFSQTVS | NQINSSGHYQ | YHTVHKDSGL | YKELLHKLHL | AKVGDCMGDS | GDKPLRRNNS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YTSYTMAICG | MPLDSFRAKE | GEQKGDEMET | LTWPNADTKK | RIRMDSYTSY | CNAVSDLHSE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SEMDMSVKAE | MGLGDRKGSS | GSLEEWYDQD | KPEVSLLFQF | LQILTACFGS | FAHGGNDVSN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AIGPLVALYL | VYKQEASTKA | ATPIWLLLYG | GVGICMGLWV | WGRRVIQTMG | KDLTPITPSS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GFSIELASAL | TVVIASNIGL | PISTTHCKVG | SVVSVGWLRS | KKAVDWRLFR | NIFMAWFVTV |
| 670 | 680 | ||||
| PISGVISAAI | MAVFKYIILP | V |