AiPD: Autoinhibited Protein Database

Gene name	At3g15140 (F4B12.5)
Protein name	Uncharacterized exonuclease domain-containing protein At3g15140
Names
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G15140
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

7-151 (Predicted disordered autoinhibitory region) PR

7-151 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8W566-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_3_5101713_G_A	2	A>V	No	1000Genomes
ENSVATH10688319	3	S>T	No	1000Genomes
ENSVATH13922077	11	S>P	No	1000Genomes
tmp_3_5101675_T_C	15	I>V	No	1000Genomes
ENSVATH00324303	17	P>R	No	1000Genomes
ENSVATH10688316	27	A>T	No	1000Genomes
ENSVATH10688315	33	H>R	No	1000Genomes
ENSVATH05834641	67	T>N	No	1000Genomes
tmp_3_5101503_T_C	72	E>G	No	1000Genomes
ENSVATH05834636	94	M>T	No	1000Genomes
tmp_3_5101138_T_C	95	D>G	No	1000Genomes
ENSVATH05834635	127	N>K	No	1000Genomes
ENSVATH05834634	128	F>I	No	1000Genomes
ENSVATH13922075	145	I>M	No	1000Genomes
tmp_3_5100623_C_T	178	E>K	No	1000Genomes
tmp_3_5100284_A_T	206	V>D	No	1000Genomes
ENSVATH00324298	220	W>G	No	1000Genomes
ENSVATH02146660	223	N>K	No	1000Genomes
ENSVATH05834624	241	E>D	No	1000Genomes
ENSVATH05834623	244	V>I	No	1000Genomes
tmp_3_5100017_C_G	263	V>L	No	1000Genomes
tmp_3_5099846_T_C	294	I>V	No	1000Genomes
ENSVATH05834619	304	V>L	No	1000Genomes
ENSVATH05834619	304	V>M	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Exonuclease, RNase T/DNA polymerase III	128 - 313	IPR013520
domain	ERI-1-like, DEDDh 3'-5' exonuclease domain	129 - 308	IPR047201

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
3'-5'-exoribonuclease activity	Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
endoribonuclease activity, producing 5'-phosphomonoesters	Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters.
metal ion binding	Binding to a metal ion.
nucleic acid binding	Binding to a nucleic acid.

Name	Definition
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript.
post-transcriptional gene silencing by RNA	A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8IV48	ERI1	3'-5' exoribonuclease 1	Homo sapiens (Human)	PR
Q7TMF2	Eri1	3'-5' exoribonuclease 1	Mus musculus (Mouse)	PR
Q5FVR4	Eri1	3'-5' exoribonuclease 1	Rattus norvegicus (Rat)	PR
O44406	eri-1	3'-5' exonuclease eri-1	Caenorhabditis elegans	PR