O44406
Gene name |
eri-1 |
Protein name |
3'-5' exonuclease eri-1 |
Names |
Enhanced RNAi protein |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_T07A9.5 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O44406
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O44406-F1 | Predicted | AlphaFoldDB |
No variants for O44406
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O44406 | |||||
No associated diseases with O44406
1 regional properties for O44406
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Di-trans-poly-cis-decaprenylcistransferase-like, conserved site | 232 - 249 | IPR018520 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5'-exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
| nucleic acid binding | Binding to a nucleic acid. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. |
| germ cell development | The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. |
| meiotic chromosome segregation | The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. |
| multicellular organismal reproductive process | The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. |
| negative regulation of post-transcriptional gene silencing by RNA | Any process that stops, prevents or reduces the frequency, rate or extent of post-transcriptional gene silencing by RNA. |
| post-transcriptional gene silencing by RNA | A posttranscriptional gene silencing pathway in which regulatory RNAs elicit silencing of specific target genes, either by mRNA destabilization or inhibition of translation. |
| RNA catabolic process | The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8IV48 | ERI1 | 3'-5' exoribonuclease 1 | Homo sapiens (Human) | PR |
| Q7TMF2 | Eri1 | 3'-5' exoribonuclease 1 | Mus musculus (Mouse) | PR |
| Q5FVR4 | Eri1 | 3'-5' exoribonuclease 1 | Rattus norvegicus (Rat) | PR |
| Q8W566 | At3g15140 | Uncharacterized exonuclease domain-containing protein At3g15140 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSADEPSPED | EKYLESLRDL | LKISQEFDAS | NAKQNDEPEK | TAVEVESAET | RTDESEKSID |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IPREQQLLPS | ERVEPLKSMV | EPEYVKKVIR | QMDTMTAEQL | KQALMKIKVS | TGGNKKTLRK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RVAQYYRKEN | ALLNRKMEPN | ADKTARFFDY | LIAIDFECTC | VEIIYDYPHE | IIELPAVLID |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VREMKIISEF | RTYVRPVRNP | KLSEFCMQFT | KIAQETVDAA | PYFREALQRL | YTWMRKFNLG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QKNSRFAFVT | DGPHDMWKFM | QFQCLLSNIR | MPHMFRSFIN | IKKTFKEKFN | GLIKGNGKSG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IENMLERLDL | SFVGNKHSGL | DDATNIAAIA | IQMMKLKIEL | RINQKCSYKE | NQRSAARKDE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ERELEDAANV | DLTSVDISRR | DFQLWMRRLP | LKLSSVTRRE | FINEEYLDCD | SCDDLTDDKN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DEAAFQEKMA | IREYLENKQT | EDFAKIAAER | GIFKIGEIKS | YQTARPIIED | DDVDVESEEE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DYGTEFEMLE | VVERMPPVSS | TLHTEVDLDA | VWERDGGSDS | ERENLSNAPS | LHEFPSSSTS |
| 550 | 560 | 570 | 580 | ||
| SPHATSEHVT | SSSPLHIDDD | VDRVLNAPPK | NSLASSSNRS | SF |