Q5FVR4
Gene name |
Eri1 (Thex1) |
Protein name |
3'-5' exoribonuclease 1 |
Names |
C-type lectin domain family 13 member A, Histone mRNA 3'-exonuclease 1 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:361159 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5FVR4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5FVR4-F1 | Predicted | AlphaFoldDB |
No variants for Q5FVR4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5FVR4 | |||||
No associated diseases with Q5FVR4
1 regional properties for Q5FVR4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Histone H2A/H2B/H3 | 17 - 102 | IPR007125 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| histone pre-mRNA 3'end processing complex | A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. |
| 3'-5'-exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
| histone pre-mRNA stem-loop binding | Binding to a conserved stem-loop structure found in histone pre-mRNAs. |
| metal ion binding | Binding to a metal ion. |
| ribosome binding | Binding to a ribosome. |
| rRNA binding | Binding to a ribosomal RNA. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. |
| gene silencing by RNA | A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. |
| rRNA 3'-end processing | Any process involved in forming the mature 3' end of an rRNA molecule. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8IV48 | ERI1 | 3'-5' exoribonuclease 1 | Homo sapiens (Human) | PR |
| Q7TMF2 | Eri1 | 3'-5' exoribonuclease 1 | Mus musculus (Mouse) | PR |
| O44406 | eri-1 | 3'-5' exonuclease eri-1 | Caenorhabditis elegans | PR |
| Q8W566 | At3g15140 | Uncharacterized exonuclease domain-containing protein At3g15140 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEDERGREHG | GDAAQQKTPR | PECEESRPLS | VEKKQRCRLD | GKDTDGSKFI | TSNGGDFSDP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VYKEIAMTNG | CINRMSKEEL | RAKLSEFKLE | TRGVKDVLKK | RLKNYYKKQK | LMLKESNAVD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SYYDYICIID | FEATCEEGNP | AEFLHEIIEF | PVVLLNTHSL | EIEDTFQQYV | RPEVNSQLSE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FCIGLTGITQ | DQVDRADAFP | QVLKKVIEWM | KSKELGTKYK | YCILTDGSWD | MSKFLNIQCQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSRLKYPSFA | KKWINIRKSY | GNFYKVPRSQ | TKLTIMLEKL | GMDYDGRPHS | GLDDSKNIAR |
| 310 | 320 | 330 | 340 | ||
| IAVRMLQDGC | ELRINEKLHG | GQLMSVSSSL | PVEGAPAPQM | PHSRK |