Q8W4D8

PR
Gene name
DDL (At3g20550, K10D20.9)
Protein name
FHA domain-containing protein DDL
Names
Protein DAWDLE
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G20550
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-161 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q8W4D8

Entry ID Method Resolution Chain Position Source
3VPY X-ray 170 A A 180-310 PDB
AF-Q8W4D8-F1 Predicted AlphaFoldDB

17 variants for Q8W4D8

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05870118 6 R>T No 1000Genomes
ENSVATH05870117 28 R>T No 1000Genomes
ENSVATH13953230 30 R>K No 1000Genomes
tmp_3_7177473_C_T 43 R>K No 1000Genomes
ENSVATH02169780 45 R>K No 1000Genomes
ENSVATH02169780 45 R>M No 1000Genomes
ENSVATH05870116 49 I>L No 1000Genomes
ENSVATH00336335 87 T>A No 1000Genomes
tmp_3_7177308_T_C 98 E>G No 1000Genomes
tmp_3_7177290_G_A 104 S>L No 1000Genomes
ENSVATH10806409 109 R>K No 1000Genomes
ENSVATH05870115 123 H>P No 1000Genomes
tmp_3_7176753_T_C 130 R>G No 1000Genomes
ENSVATH02169776 132 G>D No 1000Genomes
tmp_3_7176637_G_A 142 S>L No 1000Genomes
tmp_3_7176602_C_T 154 A>T No 1000Genomes
ENSVATH02169771 258 M>I No 1000Genomes

No associated diseases with Q8W4D8

1 regional properties for Q8W4D8

Type Name Position InterPro Accession
domain Forkhead-associated (FHA) domain 218 - 299 IPR000253

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA binding Binding to an RNA molecule or a portion thereof.

3 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
miRNA processing A process leading to the generation of a functional miRNA. Includes the cleavage of stem-loop RNA precursors into microRNAs (miRNAs). miRNAs are a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts.
regulation of developmental growth Any process that modulates the frequency, rate or extent of developmental growth.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q07930 PML1 Pre-mRNA leakage protein 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q8TAD8 SNIP1 Smad nuclear-interacting protein 1 Homo sapiens (Human) PR
Q8BIZ6 Snip1 Smad nuclear-interacting protein 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MAPSSRSPSP RTKRLRRARG EKEIGRSRER EDDGREREKR NSRERDRDIG RDRDRERKGE
70 80 90 100 110 120
GERDREVGDK RRRSGREDTE KRRRTRTDDE RYSRGRHERS TSPSDRSHRS SRRSPERAIA
130 140 150 160 170 180
SRHDEGSNAR GGSEEPNVEE DSVARMRAVE EALAAKKKEE PSFELSGKLA EETNRYRGIT
190 200 210 220 230 240
LLFNEPPEAR KPSERWRLYV FKDGEPLNEP LCLHRQSCYL FGRERRIADI PTDHPSCSKQ
250 260 270 280 290 300
HAVIQYREME KEKPDGMMGK QVKPYIMDLG STNKTYINES PIEPQRYYEL FEKDTIKFGN
310
SSREYVLLHE NSAE