Q07930
Gene name |
PML1 (YLR016C, L1591) |
Protein name |
Pre-mRNA leakage protein 1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YLR016C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
11 structures for Q07930
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2JKD | X-ray | 250 A | A/B | 25-204 | PDB |
| 2MKC | NMR | - | B | 22-42 | PDB |
| 2MY3 | NMR | - | B | 22-42 | PDB |
| 3ELS | X-ray | 180 A | A | 51-204 | PDB |
| 3ELV | X-ray | 240 A | A/B | 1-204 | PDB |
| 5GM6 | EM | 350 A | U | 1-204 | PDB |
| 5LQW | EM | 580 A | N | 1-204 | PDB |
| 5ZWM | EM | 340 A | Z | 1-204 | PDB |
| 5ZWO | EM | 390 A | Z | 1-204 | PDB |
| 7DCO | EM | 250 A | Y | 1-204 | PDB |
| AF-Q07930-F1 | Predicted | AlphaFoldDB |
7 variants for Q07930
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s12-177254 | 54 | E>D | No | SGRP | |
| s12-177187 | 77 | M>V | No | SGRP | |
| s12-176967 | 150 | G>D | No | SGRP | |
| s12-176945 | 157 | M>I | No | SGRP | |
| s12-176941 | 159 | L>M | No | SGRP | |
| s12-176938 | 160 | D>N | No | SGRP | |
| s12-176832 | 195 | N>T | No | SGRP |
No associated diseases with Q07930
1 regional properties for Q07930
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Forkhead-associated (FHA) domain | 103 - 188 | IPR000253 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RES complex | A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p. |
| spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
| U2 snRNP | A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| maintenance of RNA location | Any process in which RNA is maintained in a location and prevented from moving elsewhere. |
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| U2-type prespliceosome assembly | The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFHRRKRPYN | TRNYGHDDKK | FKSQYIDIMP | DFSPSGLLEL | ESNNKEGIAL | KHVEPQDAIS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PDNYMDMLGL | EARDRTMYEL | VIYRKNDKDK | GPWKRYDLNG | RSCYLVGREL | GHSLDTDLDD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RTEIVVADIG | IPEETSSKQH | CVIQFRNVRG | ILKCYVMDLD | SSNGTCLNNV | VIPGARYIEL |
| 190 | 200 | ||||
| RSGDVLTLSE | FEEDNDYELI | FMNV |