Q8BIZ6
Gene name |
Snip1 |
Protein name |
Smad nuclear-interacting protein 1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:76793 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BIZ6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BIZ6-F1 | Predicted | AlphaFoldDB |
21 variants for Q8BIZ6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs230082190 | 76 | S>Y | No | EVA | |
| rs13474356 | 90 | Q>R | No | EVA | |
| rs237274668 | 95 | P>S | No | EVA | |
| rs3394868486 | 108 | R>L | No | EVA | |
| rs3394938565 | 115 | Q>L | No | EVA | |
| rs3388707008 | 128 | R>Q | No | EVA | |
| rs3388707049 | 148 | R>M | No | EVA | |
| rs27553157 | 149 | P>S | No | EVA | |
| rs248166376 | 150 | V>I | No | EVA | |
| rs248166376 | 150 | V>L | No | EVA | |
| rs3388717207 | 151 | S>I | No | EVA | |
| rs3388715474 | 162 | L>P | No | EVA | |
| rs3388709328 | 163 | Q>L | No | EVA | |
| rs3388712653 | 175 | R>M | No | EVA | |
| rs387403648 | 177 | R>Q | No | EVA | |
| rs3388708897 | 234 | S>I | No | EVA | |
| rs3388703368 | 239 | A>D | No | EVA | |
| rs3388712935 | 247 | R>H | No | EVA | |
| rs3388711495 | 273 | H>D | No | EVA | |
| rs3388712972 | 278 | D>N | No | EVA | |
| rs1132077617 | 349 | F>L | No | EVA |
No associated diseases with Q8BIZ6
1 regional properties for Q8BIZ6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Forkhead-associated (FHA) domain | 267 - 348 | IPR000253 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| U2-type precatalytic spliceosome | A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| I-kappaB kinase/NF-kappaB signaling | The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. |
| miRNA processing | A process leading to the generation of a functional miRNA. Includes the cleavage of stem-loop RNA precursors into microRNAs (miRNAs). miRNAs are a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q07930 | PML1 | Pre-mRNA leakage protein 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q8TAD8 | SNIP1 | Smad nuclear-interacting protein 1 | Homo sapiens (Human) | PR |
| Q8W4D8 | DDL | FHA domain-containing protein DDL | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKAGKSERER | SGRRRHRSGD | ALTTVVVKQE | RLSPEPVAHR | RPDAPAASLS | PPAAEPGHSG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HRGSRARSPA | KKKSKSSGRR | SKSPRTKRSQ | SPHYPMVKVK | QEREDHPRRG | REDRQHREPS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EQEHRRARNS | ERDRHRGHSR | QGRSSDERPV | SGQDRDRDSQ | NLQAQEEERD | FHNARRREHR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QQNESAGSEA | QEVIPRPAGN | RSKEVPVKEK | PSFELSGALL | EDTNTFRGVV | IKYSEPPEAR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IPKKRWRLYP | FKNDEVLPVM | YIHRQSAYLL | GRHRRIADIP | IDHPSCSKQH | AVFQYRLVEY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TRADGTVGRR | VKPYIIDLGS | GNGTFLNNKR | IEPQRYYELK | EKDVLKFGFS | SREYVLLHES |
| 370 | 380 | ||||
| SDTSELDRKE | DEDDEEEEMV | SDS |