Q8VHU4

PR
Gene name
Elp1 (Ikap, Ikbkap)
Protein name
Elongator complex protein 1
Names
ELP1, IkappaB kinase complex-associated protein, IKK complex-associated protein
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:140934
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1147-1233 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VHU4

Entry ID Method Resolution Chain Position Source
AF-Q8VHU4-F1 Predicted AlphaFoldDB

No variants for Q8VHU4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8VHU4

No associated diseases with Q8VHU4

1 regional properties for Q8VHU4

Type Name Position InterPro Accession
conserved_site ELO family, conserved site 137 - 145 IPR030457

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
elongator holoenzyme complex A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein self-association Binding to a domain within the same polypeptide.
tRNA binding Binding to a transfer RNA.

3 GO annotations of biological process

Name Definition
I-kappaB phosphorylation The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine.
tRNA wobble uridine modification The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O95163 ELP1 Elongator complex protein 1 Homo sapiens (Human) PR
Q7TT37 Elp1 Elongator complex protein 1 Mus musculus (Mouse) PR
Q9FNA4 ELP1 Elongator complex protein 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRNLKLHQTL EFRDIQAPGK PQCFCLRAEQ GTVLIGSERG LTEVDPVKKE VKTEISLVAE
70 80 90 100 110 120
GFLPEDGSGC IVGIQDLLDQ ESVCVATASG DVIVCNVSTQ QLECVGNVAS GISVMSWSPD
130 140 150 160 170 180
QELLLLATAQ QTLIMMTRDY EVITEQQIHQ DDFGEGKFIT VGWGSKDTQF HGSEGRPITF
190 200 210 220 230 240
PVQMHESALS WDDHRPQITW RGDGQFFAVS VVCSQTGARK IRVWNREFAL QSTSESVPGL
250 260 270 280 290 300
GPSLAWKPSG SLIASTQDKP NQQDVVFFEK NGLLHGYFTL PFLKDEVKVN DLLWNADSSV
310 320 330 340 350 360
LAVWLEDLPK EGSSTLKSYV QLWTVGNYHW YLKQSLPFST TGKNQIVSLL WDPVTPGRLH
370 380 390 400 410 420
VLCQGWRYLC CDWHWTTDRS SGNSADDLAN VAVIDGNKVL VTVFQRTVTP PPMCTYRLLI
430 440 450 460 470 480
PHPVNQVMSS AHLGNDLAVL DASNQISVYK CDDKPDMDST VKLGAVGGTG FKVPLRTPHL
490 500 510 520 530 540
EKRYRIQFGN KEEEEDVSPL QFRFLTWIEG DAFLAISHSH SSPQSIIHHL TMAGSEGDEE
550 560 570 580 590 600
QGQLNVSSSV TVDGVVIGLC CCSKTKSSAV QLADGQVLKY LWESPSSAVE PWKNSEGRPV
610 620 630 640 650 660
RFARPCTQME AAAIGGEECV LGLTDRCRFF INDTEVASNI TSFAVCDDFL LVTTHSHTCQ
670 680 690 700 710 720
CFSLSGASLK MLQAGLCGSQ VPSGEILRKV ERGSRIVTVV PQDTKLILQM PRGNLEVVHH
730 740 750 760 770 780
RALVLAQIRK WLDKLMFKEA FECMRKLRIN LNLIHDHNPK VFLENVETFI KQIDSVNHLN
790 800 810 820 830 840
LFFTELKEED VTKTMYPPPV TKSVQVSTNP DGKKVDLICD AMRVAMETIN PRKFCLSILT
850 860 870 880 890 900
SHVKKTTPEL DIVLQKVHEL QGKIPFVPES VSAEEALKYL LLLVDVNELF NHSLGTYDFD
910 920 930 940 950 960
LVLMVAEKSQ KDPKEYLPFL NTLKKMETNY QRFTIDKYLK RYEKALGHLS KCGPEYFTEC
970 980 990 1000 1010 1020
LNLIKDKNLY KEALKLYRPD SPQYQAVSVA YGEHLVQELL YEPAGLVFAR CGAHEKALEA
1030 1040 1050 1060 1070 1080
FLACGSWQQA LCMAAQLQMA KDKVAGLART LAGKLVEQRK HSEAATVLEQ YALDYEEAVL
1090 1100 1110 1120 1130 1140
LLLEGSAWEE ALRLVYKYDR VDIIETSVKP SILEAQKNYM DFLDSQTATF IRHKNRLKVV
1150 1160 1170 1180 1190 1200
RELKSQRPRV HVDHEVAHGR ETDLFSETSS IRSGSEMSGR YSHSNSRISA RSSKNRRKAE
1210 1220 1230 1240 1250 1260
RKKHSLKEGS PLEGLALLEA LSEVVQSIEK LKDEVHAILK VLFLFEFEEQ ARELQRAFES
1270 1280 1290 1300 1310 1320
TLQLMGTALP DIWTLTGQQS SSTPVLGPSS TVNSIMASYQ QQKTCVPVLD AWACLPPKID
1330
QRSQWKLSLL E