Q7TT37

PR
Gene name
Elp1 (Ikap, Ikbkap)
Protein name
Elongator complex protein 1
Names
ELP1, IkappaB kinase complex-associated protein, IKK complex-associated protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:230233
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1155-1227 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q7TT37

Entry ID Method Resolution Chain Position Source
8AVG EM 401 A A 1-1333 PDB
AF-Q7TT37-F1 Predicted AlphaFoldDB

73 variants for Q7TT37

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388686261 66 D>* No EVA
rs3388686322 69 G>C No EVA
rs3388684339 86 A>T No EVA
rs3388685157 95 C>W No EVA
rs3388680756 99 T>A No EVA
rs256733948 113 S>A No EVA
rs3388682828 166 K>E No EVA
rs27869825 194 R>H No EVA
rs3388672764 203 D>G No EVA
rs3388683273 207 F>V No EVA
rs3388686258 217 E>D No EVA
rs3388687877 238 P>T No EVA
rs3388683262 241 G>W No EVA
rs3388664311 246 W>* No EVA
rs27869827 303 I>V No EVA
rs3394295514 322 L>I No EVA
rs3394276563 322 L>R No EVA
rs3394415825 326 G>W No EVA
rs237713872 343 K>E No EVA
rs27869828 346 I>V No EVA
rs3388687892 408 V>D No EVA
rs3388684318 409 V>A No EVA
rs3388686869 422 H>D No EVA
rs215960770 440 L>F No EVA
rs256530725 442 A>T No EVA
rs233072932 455 P>S No EVA
rs233072932 455 P>T No EVA
rs3388680406 456 N>Y No EVA
rs3388680433 480 L>M No EVA
rs230974361 501 A>V No EVA
rs260544472 528 I>V No EVA
rs3394015328 531 H>GSQSNGE* No EVA
rs3394318678 532 L>W No EVA
rs27869832 535 T>A No EVA
rs3388685120 570 L>* No EVA
rs3394292657 595 K>R No EVA
rs3388682837 608 C>Y No EVA
rs3388673283 631 F>I No EVA
rs3388677280 637 E>V No EVA
rs3388672720 647 V>L No EVA
rs3388684363 656 T>A No EVA
rs27869847 663 V>G No EVA
rs3388686823 669 A>D No EVA
rs3388686823 669 A>V No EVA
rs3394290718 670 S>L No EVA
rs3394015297 672 K>* No EVA
rs3394276567 672 K>I No EVA
rs3388672680 715 G>E No EVA
rs3394202982 725 L>M No EVA
rs3394292627 734 L>R No EVA
rs3388672738 735 D>N No EVA
rs3388686825 779 N>T No EVA
rs3388683306 813 D>N No EVA
rs3388689627 816 K>* No EVA
rs3388686306 859 V>E No EVA
rs3394248940 939 K>E No EVA
rs3394336635 983 S>P No EVA
rs227392230 991 M>V No EVA
rs3388672759 1004 E>K No EVA
rs230356350 1011 A>V No EVA
rs3388686011 1023 F>C No EVA
rs3388672691 1048 G>D No EVA
rs3388686284 1107 E>D No EVA
rs49409972 1110 V>I No EVA
rs3388685975 1130 A>V No EVA
rs236798523 1154 V>M No EVA
rs3388680409 1156 H>D No EVA
rs3394248965 1237 V>LALQTQRERAPSK* No EVA
rs239818104 1286 P>Q No EVA
rs3388685154 1289 G>D No EVA
rs3388664287 1303 Q>H No EVA
rs27835086 1310 A>V No EVA
rs13468534 1334 E>W No EVA

No associated diseases with Q7TT37

8 regional properties for Q7TT37

Type Name Position InterPro Accession
repeat WD40 repeat 426 - 474 IPR001680-1
repeat WD40 repeat 585 - 626 IPR001680-2
repeat WD40 repeat 629 - 667 IPR001680-3
repeat WD40 repeat 670 - 709 IPR001680-4
repeat WD40 repeat 713 - 753 IPR001680-5
repeat WD40 repeat 765 - 809 IPR001680-6
domain BOP1, N-terminal domain 167 - 426 IPR012953
conserved_site WD40 repeat, conserved site 452 - 466 IPR019775

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
elongator holoenzyme complex A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein self-association Binding to a domain within the same polypeptide.
tRNA binding Binding to a transfer RNA.

3 GO annotations of biological process

Name Definition
I-kappaB phosphorylation The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine.
tRNA wobble uridine modification The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O95163 ELP1 Elongator complex protein 1 Homo sapiens (Human) PR
Q8VHU4 Elp1 Elongator complex protein 1 Rattus norvegicus (Rat) PR
Q9FNA4 ELP1 Elongator complex protein 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRNLKLHRTL EFRDIQAPGK PQCFCLRAEQ GTVLIGSERG LTEVDPVRRE VKTEISLVAE
70 80 90 100 110 120
GFLPEDGSGC IVGIQDLLDQ ESVCVATASG DVIVCNLSTQ QLECVGSVAS GISVMSWSPD
130 140 150 160 170 180
QELLLLATAQ QTLIMMTKDF EVIAEEQIHQ DDFGEGKFVT VGWGSKQTQF HGSEGRPTAF
190 200 210 220 230 240
PVQLPENALP WDDRRPHITW RGDGQYFAVS VVCRQTEARK IRVWNREFAL QSTSESVPGL
250 260 270 280 290 300
GPALAWKPSG SLIASTQDKP NQQDVVFFEK NGLLHGHFTL PFLKDEVKVN DLLWNADSSV
310 320 330 340 350 360
LAIWLEDLPK EDSSTLKSYV QLWTVGNYHW YLKQSLPFST TGKNQIVSLL WDPVTPCRLH
370 380 390 400 410 420
VLCTGWRYLC CDWHWTTDRS SGNSANDLAN VAVIDGNRVL VTVFRQTVVP PPMCTYRLLI
430 440 450 460 470 480
PHPVNQVIFS AHLGNDLAVL DASNQISVYK CGDKPNMDST VKLGAVGGNG FKVPLTTPHL
490 500 510 520 530 540
EKRYSIQFGN NEEEEEEEVN ALQLSFLTWV EDDTFLAISY SHSSSQSIIH HLTVTHSEVD
550 560 570 580 590 600
EEQGQLDVSS SVTVDGVVIG LCCCSKTKSL AVQLADGQVL KYLWESPSLA VEPWKNSEGI
610 620 630 640 650 660
PVRFVHPCTQ MEVATIGGEE CVLGLTDRCR FFINDTEVAS NITSFAVCDD FLLVTTHSHT
670 680 690 700 710 720
CQVFSLSGAS LKMLQAALSG SHEASGEILR KVERGSRIVT VVPQDTKLIL QMPRGNLEVV
730 740 750 760 770 780
HHRALVLAQI RKWLDKLMFK EAFECMRKLR INLNLIHDHN PKVFLENVET FVKQIDSVNH
790 800 810 820 830 840
INLFFTELRE EDVTKTMYPP PITKSVQVST HPDGKKLDLI CDAMRAAMEA INPRKFCLSI
850 860 870 880 890 900
LTSHVKKTTP ELEIVLQKVQ ELQGNLPFDP ESVSVEEALK YLLLLVDVNE LFNHSLGTYD
910 920 930 940 950 960
FNLVLMVAEK SQKDPKEYLP FLNTLKKMET NYQRFTIDKY LKRYEKALGH LSKCGPEYFT
970 980 990 1000 1010 1020
ECLNLIKDKN LYKEALKLYR PDSPQYQAVS MAYGEHLMQE HLYEPAGLVF ARCGAQEKAL
1030 1040 1050 1060 1070 1080
EAFLACGSWQ QALCVAAQLQ MSKDKVAGLA RTLAGKLVEQ RKHSEAATVL EQYAQDYEEA
1090 1100 1110 1120 1130 1140
VLLLLEGSAW EEALRLVYKY DRVDIIETSV KPSILEAQKN YMDFLDSETA TFIRHKNRLQ
1150 1160 1170 1180 1190 1200
VVRALRRQAP QVHVDHEVAH GPESDLFSET SSIMSGSEMS GRYSHSNSRI SARSSKNRRK
1210 1220 1230 1240 1250 1260
AERKKHSLKE GSPLEGLALL EALSEVVQSV EKLKDEVRAI LKVLFLFEFE EQAKELQRAF
1270 1280 1290 1300 1310 1320
ESTLQLMERA VPEIWTPAGQ QSSTTPVLGP SSTANSITAS YQQQKTCVPA LDAGVYMPPK
1330
MDPRSQWKLS LLE