Q8VDM1

PR
Gene name
Zgpat (Kiaa1847)
Protein name
Zinc finger CCCH-type with G patch domain-containing protein
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:229007
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

236-325 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VDM1

Entry ID Method Resolution Chain Position Source
AF-Q8VDM1-F1 Predicted AlphaFoldDB

15 variants for Q8VDM1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388616744 18 Q>* No EVA
rs3388604493 135 A>V No EVA
rs3388613468 174 K>N No EVA
rs3388617257 306 F>L No EVA
rs3388616746 319 K>T No EVA
rs247387217 322 V>I No EVA
rs247387217 322 V>L No EVA
rs3388616724 385 P>H No EVA
rs48076297 391 P>S No EVA
rs3388618941 452 D>Y No EVA
rs3392634484 458 E>V No EVA
rs3392645325 483 R>L No EVA
rs3392645341 484 Q>P No EVA
rs3388614224 501 K>M No EVA
rs3388616794 508 M>I No EVA

No associated diseases with Q8VDM1

5 regional properties for Q8VDM1

Type Name Position InterPro Accession
domain TRAM domain 504 - 580 IPR002792
domain Elp3/MiaA/NifB-like, radical SAM core domain 250 - 490 IPR006638
domain Radical SAM 91 - 584 IPR007197
domain Methylthiotransferase, N-terminal 93 - 222 IPR013848
conserved_site Methylthiotransferase, conserved site 254 - 274 IPR020612

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription repressor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.
metal ion binding Binding to a metal ion.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

4 GO annotations of biological process

Name Definition
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of epidermal growth factor-activated receptor activity Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VL59 CG4709 Zinc finger CCCH-type with G patch domain-containing protein Drosophila melanogaster (Fruit fly) PR
Q8N5A5 ZGPAT Zinc finger CCCH-type with G patch domain-containing protein Homo sapiens (Human) PR
10 20 30 40 50 60
MDEDNLETAL QTYRAQLQQV ELALGAGLDA SEQADLRQLQ GDLKELIELT EASLLSVRKS
70 80 90 100 110 120
KLLSTVDQES PAQEDAEYLA FQKAIAEEVE APGAPCNDSE TAPGSEVQPG STSSALEEEE
130 140 150 160 170 180
EDPDLEELSG AKVNAPYYSA WGTLEYHNAM VVGAEEAEDG SACVRVLYLY PTHKSLKPCP
190 200 210 220 230 240
FFLEGKCRFK ENCRFSHGQV VSVDELRPFQ DPDLSLLQTG SACLAKHQDG LWHPARITDV
250 260 270 280 290 300
DNGYYTVKFD SLLLKEAVVE GDSILPPLRT EATESSDSDT GDASDSSYAR VVEPSTVDTG
310 320 330 340 350 360
TCSSAFAGWE VHTRGIGSKL LVKMGYEFGK GLGRHAEGRV EPIHAVVLPR GKSLDQCAEI
370 380 390 400 410 420
LQKKTKRGQA GSNRPPKCRR SGSRPEGRPP PRNVFDFLNE KLQSQVPGTP DAGVDTPERR
430 440 450 460 470 480
NKDMYHASKS AKQALSLQLF QTEEKIERTQ RDIRGIQEAL TRNTGRHNMT TAHLQEKLEG
490 500 510
AQRQLGQLRA QEADLQRKQR KADTHRKMTE F