Q8VDG7

PR
Gene name
Pafah2
Protein name
Platelet-activating factor acetylhydrolase 2, cytoplasmic
Names
PAF:lysophospholipid transacetylase, PAF:sphingosine transacetylase, Platelet-activating factor acetyltransferase PAFAH2, Serine-dependent phospholipase A2, SD-PLA2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:100163
EC number
2.3.1.149: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

111-198 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8VDG7

Entry ID Method Resolution Chain Position Source
AF-Q8VDG7-F1 Predicted AlphaFoldDB

26 variants for Q8VDG7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388706069 104 I>S No EVA
rs3388714650 120 C>Y No EVA
rs3395032130 126 R>C No EVA
rs254774812 156 A>T No EVA
rs3388717643 203 G>R No EVA
rs227379060 223 I>V No EVA
rs239632579 225 R>T No EVA
rs263409397 226 N>S No EVA
rs3388720501 229 A>S No EVA
rs3388721225 243 A>D No EVA
rs3388726272 244 L>M No EVA
rs3388720146 247 E>K No EVA
rs3388716203 248 V>D No EVA
rs3388726291 249 Q>K No EVA
rs3388719167 270 K>E No EVA
rs3388717570 272 R>W No EVA
rs3388719161 277 F>V No EVA
rs3388714295 284 Q>R No EVA
rs239685044 289 V>I No EVA
rs3388719116 290 N>K No EVA
rs1134901660 300 E>G No EVA
rs3388724178 332 S>R No EVA
rs234660596 351 I>M No EVA
rs3388724247 359 L>R No EVA
rs3388721186 369 S>N No EVA
rs3388697194 377 P>T No EVA

No associated diseases with Q8VDG7

No regional properties for Q8VDG7

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8VDG7

Functions

Description
EC Number 2.3.1.149 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Cytoplasm
  • Membrane ; Lipid-anchor
  • Endoplasmic reticulum membrane ; Lipid-anchor
  • In resting cells, localizes to intracellular membranes and cytoplasm
  • Translocates from the cytoplasm to intracellular membranes upon oxidative stress
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.

2 GO annotations of molecular function

Name Definition
1-alkyl-2-acetylglycerophosphocholine esterase activity Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
platelet-activating factor acetyltransferase activity Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid.

2 GO annotations of biological process

Name Definition
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P83006 Pafah2 Platelet-activating factor acetylhydrolase 2, cytoplasmic Rattus norvegicus (Rat) PR
Q22943 paf-2 Platelet-activating factor acetylhydrolase homolog 2 Caenorhabditis elegans PR
10 20 30 40 50 60
MGAGQSVCFP PISGPHHIGC TDVMEGHSLE GSLFRLFYPC QASEKCEQPL WIPRYEYSMG
70 80 90 100 110 120
LADYLQYNKR WVGLLFNVGI GSCRLPVSWN GPFKAKESGY PLIILSHGLG GFRASYSAFC
130 140 150 160 170 180
MELASRGFVV AAVEHRDQSA AATYFCKPTS QESSPAESLE EEWLPFRRIK EGEKEFHVRN
190 200 210 220 230 240
PQVHQRVKEC VRVLRILQDA SAGKTVVNVF PGGLDLMTLK GSIDRNRVAV MGHSFGGATA
250 260 270 280 290 300
VLALTQEVQF RCAIALDAWM FPLERDFYPK ARGPVFFINV EKFQTVESVN LMKKICAQHE
310 320 330 340 350 360
QSRIVTVLGA VHRSQTDFAF VTGNLIAKFF SSNSRGTLDP YESQEVMVRA ILAFLQKHLD
370 380
LKEDYDQWSS FIEGVGPSLI QGAPHYLSSL