P83006

PR
Gene name
Pafah2
Protein name
Platelet-activating factor acetylhydrolase 2, cytoplasmic
Names
PAF:lysophospholipid transacetylase, PAF:sphingosine transacetylase, Platelet-activating factor acetyltransferase PAFAH2, Serine-dependent phospholipase A2, SD-PLA2
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:313611
EC number
2.3.1.149: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

113-196 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P83006

Entry ID Method Resolution Chain Position Source
AF-P83006-F1 Predicted AlphaFoldDB

No variants for P83006

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P83006

No associated diseases with P83006

No regional properties for P83006

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P83006

Functions

Description
EC Number 2.3.1.149 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Microsome membrane ; Lipid-anchor
  • Mitochondrion membrane ; Lipid-anchor
  • Cytoplasm
  • Endoplasmic reticulum membrane ; Lipid-anchor
  • In resting cells, localizes to intracellular membranes and cytoplasm
  • Translocates from the cytoplasm to intracellular membranes upon oxidative stress
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

2 GO annotations of molecular function

Name Definition
1-alkyl-2-acetylglycerophosphocholine esterase activity Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
platelet-activating factor acetyltransferase activity Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid.

2 GO annotations of biological process

Name Definition
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8VDG7 Pafah2 Platelet-activating factor acetylhydrolase 2, cytoplasmic Mus musculus (Mouse) PR
Q22943 paf-2 Platelet-activating factor acetylhydrolase homolog 2 Caenorhabditis elegans PR
10 20 30 40 50 60
MGAGQSICFP PISGPHHIGC TDVMEGHSLE GSLFRLFYPC EASETCEQPL WIPRYEYCVG
70 80 90 100 110 120
LADYLQYNKR WVGLLFNVGI GSCRLPVSWN GPFKTKESGY PLIILSHGLG GFRVSYSAFC
130 140 150 160 170 180
MELASRGFVV AAIEHRDQSA AATYFCKQTS QESSPTESLE EEWIPFRRIK EGEKEFHVRN
190 200 210 220 230 240
PQVHQRAKEC VRVLQILQDA SAGKPVINVF PGGLDLMTLK GSIDMSRVAV MGHSFGGATA
250 260 270 280 290 300
ILALTQEAQF RCAIALDAWM FPLEHDFYPK ARGPVFFINV EKFQTVESVN LMKKICAQHE
310 320 330 340 350 360
QSRIVTVLGA VHRSQTDFAF VTGNMIGKLF SSGTRGTLDP YEGQEVMVRA MLAFLQKHLD
370 380
LKEDYDQWNS FIEGIGPSLI QGAPHYLSSL