Q22943

PR
Gene name
paf-2 (C52B9.7)
Protein name
Platelet-activating factor acetylhydrolase homolog 2
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C52B9.7
EC number
3.1.1.47: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

51-130 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q22943

Entry ID Method Resolution Chain Position Source
AF-Q22943-F1 Predicted AlphaFoldDB

No variants for Q22943

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q22943

No associated diseases with Q22943

No regional properties for Q22943

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q22943

Functions

Description
EC Number 3.1.1.47 Carboxylic ester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.

1 GO annotations of molecular function

Name Definition
1-alkyl-2-acetylglycerophosphocholine esterase activity Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

2 GO annotations of biological process

Name Definition
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
morphogenesis of embryonic epithelium The process in which the anatomical structures of embryonic epithelia are generated and organized.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8VDG7 Pafah2 Platelet-activating factor acetylhydrolase 2, cytoplasmic Mus musculus (Mouse) PR
P83006 Pafah2 Platelet-activating factor acetylhydrolase 2, cytoplasmic Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGSYISSPQV LTRQVSGQFQ VGCKDLMIDG TVLGDRGLFM RLYFPTDSQA ADISSYPLWL
70 80 90 100 110 120
PKPQYAHGLG EYLGQSSQKM NVITSTVVGE KREDCIENAQ MSTKCDKWPI VVFSHGLGGS
130 140 150 160 170 180
RTFYSTYCTS LASHGYVVAA VEHKDHSACW TYQLTEKNGE LVEQPIKIKL IEKNEKNEFK
190 200 210 220 230 240
IRNQQVGKRV TECVKALNVL EQLNLGTVPE KVLIGNDYNW AQFKNKLVMS SASVIGHSFG
250 260 270 280 290 300
GATSLASSAY TTDFQKAIVF DGWMYPLDST QQEQAKQPTL FLNVGDWQWN ENLDVMKKII
310 320 330 340 350 360
SHNDGNLALT LNGAVHQCFS DFPFIFPSWL AKKFGVQGRT EPSLCMQAAI ELSLAFLENG
370 380
KDGAQKLKDE KFSSFISNEI YGREKYKL