Q8S403
Gene name |
PHO1 |
Protein name |
Phosphate transporter PHO1 |
Names |
Protein PHO1, AtPHO1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G23430 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8S403
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8S403-F1 | Predicted | AlphaFoldDB |
17 variants for Q8S403
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH10899334 | 32 | K>N | No | 1000Genomes | |
| tmp_3_8393076_G_A | 56 | S>F | No | 1000Genomes | |
| ENSVATH13980861 | 72 | L>I | No | 1000Genomes | |
| ENSVATH10899333 | 74 | S>T | No | 1000Genomes | |
| ENSVATH10899249 | 117 | V>M | No | 1000Genomes | |
| tmp_3_8391333_C_G | 152 | E>Q | No | 1000Genomes | |
| tmp_3_8391252_A_G | 179 | S>P | No | 1000Genomes | |
| ENSVATH13980832 | 187 | F>L | No | 1000Genomes | |
| ENSVATH10899217 | 255 | S>F | No | 1000Genomes | |
| ENSVATH13980767 | 429 | F>I | No | 1000Genomes | |
| tmp_3_8389036_A_C | 515 | F>C | No | 1000Genomes | |
| tmp_3_8388835_A_C | 555 | F>C | No | 1000Genomes | |
| ENSVATH02186144 | 613 | M>T | No | 1000Genomes | |
| ENSVATH13980744 | 641 | A>V | No | 1000Genomes | |
| ENSVATH13980742 | 688 | N>I | No | 1000Genomes | |
| ENSVATH05895587 | 728 | P>T | No | 1000Genomes | |
| ENSVATH00342821 | 744 | I>V | No | 1000Genomes |
No associated diseases with Q8S403
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| inositol hexakisphosphate binding | Binding to inositol hexakisphosphate. |
| phosphate ion transmembrane transporter activity | Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to phosphate starvation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate. |
| inositol phosphate-mediated signaling | A intracellular signal transduction in which the signal is transmitted within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6). |
| phosphate ion transport | The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| polyphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVKFSKELEA | QLIPEWKEAF | VNYCLLKKQI | KKIKTSRKPK | PASHYPIGHH | SDFGRSLFDP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VRKLARTFSD | KLFSNSEKPE | ILQVRRRRGS | SETGDDVDEI | YQTELVQLFS | EEDEVKVFFA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RLDEELNKVN | QFHKPKETEF | LERGEILKKQ | LETLAELKQI | LSDRKKRNLS | GSNSHRSFSS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SVRNSDFSAG | SPGELSEIQS | ETSRTDEIIE | ALERNGVSFI | NSATRSKTKG | GKPKMSLRVD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IPDAVAGAEG | GIARSIATAM | SVLWEELVNN | PRSDFTNWKN | IQSAEKKIRS | AFVELYRGLG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LLKTYSSLNM | IAFTKIMKKF | DKVAGQNASS | TYLKVVKRSQ | FISSDKVVRL | MDEVESIFTK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HFANNDRKKA | MKFLKPHQTK | DSHMVTFFVG | LFTGCFISLF | VIYIILAHLS | GIFTSSDQVS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YLETVYPVFS | VFALLSLHMF | MYGCNLYMWK | NTRINYTFIF | EFAPNTALRY | RDAFLMGTTF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MTSVVAAMVI | HLILRASGFS | ASQVDTIPGI | LLLIFICVLI | CPFNTFYRPT | RFCFIRILRK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IVCSPFYKVL | MVDFFMGDQL | TSQIPLLRHL | ETTGCYFLAQ | SFKTHEYNTC | KNGRYYREFA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YLISFLPYFW | RAMQCVRRWW | DESNPDHLIN | MGKYVSAMVA | AGVRITYARE | NNDLWLTMVL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VSSVVATIYQ | LYWDFVKDWG | LLNPKSKNPW | LRDNLVLRNK | NFYYLSIALN | LVLRVAWIET |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IMRFRVSPVQ | SHLLDFFLAS | LEVIRRGHWN | FYRVENEHLN | NVGQFRAVKT | VPLPFLDRDS |
| DG |