Q8R3J4
Gene name |
Mterf3 (Mterfd1, CGI-12) |
Protein name |
Transcription termination factor 3, mitochondrial |
Names |
Mitochondrial transcription termination factor 3, mTERF3, mTERF domain-containing protein 1, mitochondrial |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:66410 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8R3J4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8R3J4-F1 | Predicted | AlphaFoldDB |
24 variants for Q8R3J4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs259310432 | 28 | K>N | No | EVA | |
| rs248837625 | 29 | R>H | No | EVA | |
| rs228593336 | 37 | V>E | No | EVA | |
| rs262002607 | 45 | P>A | No | EVA | |
| rs230903923 | 51 | T>A | No | EVA | |
| rs46881587 | 52 | S>C | No | EVA | |
| rs3389264836 | 67 | N>I | No | EVA | |
| rs220529112 | 73 | S>N | No | EVA | |
| rs3404295890 | 80 | S>A | No | EVA | |
| rs3389292596 | 89 | V>M | No | EVA | |
| rs230972593 | 108 | V>L | No | EVA | |
| rs3389256614 | 112 | P>S | No | EVA | |
| rs3389288301 | 119 | S>L | No | EVA | |
| rs3404403306 | 135 | P>H | No | EVA | |
| rs3389264865 | 150 | T>S | No | EVA | |
| rs249482841 | 241 | N>K | No | EVA | |
| rs49329505 | 253 | L>V | No | EVA | |
| rs3389218480 | 292 | N>D | No | EVA | |
| rs3389288282 | 295 | V>A | No | EVA | |
| rs3389264881 | 310 | M>T | No | EVA | |
| rs3389298092 | 323 | R>G | No | EVA | |
| rs213637416 | 328 | I>T | No | EVA | |
| rs864300840 | 399 | K>Q | No | EVA | |
| rs864271418 | 412 | L>R | No | EVA |
No associated diseases with Q8R3J4
No regional properties for Q8R3J4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8R3J4 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial ribosome assembly | The aggregation, arrangement and bonding together of the mitochondrial ribosome and of its subunits. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5ZJC8 | MTERF3 | Transcription termination factor 3, mitochondrial | Gallus gallus (Chicken) | PR |
| Q99551 | MTERF1 | Transcription termination factor 1, mitochondrial | Homo sapiens (Human) | PR |
| Q96E29 | MTERF3 | Transcription termination factor 3, mitochondrial | Homo sapiens (Human) | PR |
| Q8CHZ9 | Mterf1a | Transcription termination factor 1a, mitochondrial | Mus musculus (Mouse) | PR |
| B9EJ57 | Mterf1b | Transcription termination factor 1b, mitochondrial | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALLAQQLPR | RFNSVKLTSF | IKAKQVTKRS | ARAGKAVLPG | FSAQPLLSSD | TSFLRRGIKT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YRTLFWNRFH | SASTNRTKSS | AESTLLPSVA | EQQERILSLE | SELPLEEVDD | LPPLSPLQSV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SEEEAIQIAA | YSPLPISSFT | LADYVDHSKT | LQKLVQLGVD | LSKIEKHPDA | ANLLLRLDFE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KHIKQILLFL | KDLGLEDNQL | GPFLTKNYAI | FSEDLENLKT | RVAYLQSKNF | SKTDIARMVK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NAPFLLSFSV | ERLDNRLGFF | QKELELNVKK | TRDLVVRLPR | LLTGSLEPVK | ENMKVYHLEL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GFKHNEIQHM | VIKIPKMLTA | NKRKLTEIFD | YVHNVMNIPH | HIIVKFPQLF | NTRVFKIKER |
| 370 | 380 | 390 | 400 | 410 | |
| HLFLAYLGRA | QYDPAKPNYV | SLDKFVSFPD | KIFCKEIAKA | SLNDFEKFLK | TL |