Q8CHZ9
Gene name |
Mterf1a (Mterf, Mterf1) |
Protein name |
Transcription termination factor 1a, mitochondrial |
Names |
Mitochondrial transcription termination factor 1a, mTERF1a |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:545725 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CHZ9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CHZ9-F1 | Predicted | AlphaFoldDB |
19 variants for Q8CHZ9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs31192806 | 19 | D>G | No | EVA | |
| rs586543897 | 26 | A>T | No | EVA | |
| rs3388738999 | 33 | I>N | No | EVA | |
| rs3388742087 | 34 | S>L | No | EVA | |
| rs31192809 | 40 | A>V | No | EVA | |
| rs3388744498 | 73 | R>K | No | EVA | |
| rs3388734580 | 93 | L>H | No | EVA | |
| rs3388737889 | 102 | V>E | No | EVA | |
| rs3388741807 | 103 | I>S | No | EVA | |
| rs3388741193 | 123 | K>Q | No | EVA | |
| rs3388741223 | 136 | L>P | No | EVA | |
| rs3388742205 | 201 | Q>L | No | EVA | |
| rs3388741758 | 223 | N>H | No | EVA | |
| rs3388738995 | 223 | N>S | No | EVA | |
| rs583858258 | 250 | R>Q | No | EVA | |
| rs3388741738 | 268 | N>I | No | EVA | |
| rs587493289 | 320 | E>G | No | EVA | |
| rs583957628 | 322 | I>V | No | EVA | |
| rs579577912 | 355 | L>F | No | EVA |
No associated diseases with Q8CHZ9
No regional properties for Q8CHZ9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8CHZ9 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrial nucleoid | The region of a mitochondrion to which the DNA is confined. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| double-stranded DNA binding | Binding to double-stranded DNA. |
| nucleic acid binding | Binding to a nucleic acid. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA geometric change | The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases. |
| DNA-templated transcription termination | The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| termination of mitochondrial transcription | A transcription termination process that completes the production of a primary mitochondrial transcript. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5ZJC8 | MTERF3 | Transcription termination factor 3, mitochondrial | Gallus gallus (Chicken) | PR |
| Q96E29 | MTERF3 | Transcription termination factor 3, mitochondrial | Homo sapiens (Human) | PR |
| Q99551 | MTERF1 | Transcription termination factor 1, mitochondrial | Homo sapiens (Human) | PR |
| Q8R3J4 | Mterf3 | Transcription termination factor 3, mitochondrial | Mus musculus (Mouse) | PR |
| B9EJ57 | Mterf1b | Transcription termination factor 1b, mitochondrial | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASRNIWCVR | RNFLFDLRDW | MLQYSAEVFL | KSISFRPFSA | ECDSKDKESL | EEEREDLLSN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LVTMGVDIDM | ARRRQPGVFN | KAVTNEQELK | LFLLSKGASD | KVIGSIISRY | PRAITRTPES |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSKRWDLWRK | IMASDLEIVN | ILERSPESFF | RSNNNLNLEN | NIKFLCSVGL | THKCLCRLLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NAPRTFSNSL | NLNKQMVEFL | QETGMSLGHN | DPRDFVRKII | SKNPSILIQS | TKRVKTNIEF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LQSTFNLNKR | DLLLLICGPG | ARILDLSNDC | TKKNYTNIRE | RLLSLGCSEE | EVQRFVLSYL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NMVFLSEKKF | NDKIDCLIEE | KISASQIIEN | PRILDSSINT | LKTRIRELSH | AGYDLSTSSI |
| 370 | |||||
| ALLSWSQRRY | EAKLKRLCG |