Q8R071

PR
Gene name
Itpka
Protein name
Inositol-trisphosphate 3-kinase A
Names
Inositol 1,4,5-trisphosphate 3-kinase A, IP3 3-kinase A, IP3K A, InsP 3-kinase A
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:228550
EC number
2.7.1.127: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

85-174 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8R071

Entry ID Method Resolution Chain Position Source
AF-Q8R071-F1 Predicted AlphaFoldDB

15 variants for Q8R071

Variant ID(s) Position Change Description Diseaes Association Provenance
rs229258596 91 T>A No EVA
rs213176506 100 Q>P No EVA
rs3388580681 166 Q>R No EVA
rs3388578782 171 M>K No EVA
rs3388569988 263 M>T No EVA
rs3388581365 266 R>K No EVA
rs3391971712 291 L>M No EVA
rs3388579828 298 P>S No EVA
rs864273676 302 E>G No EVA
rs3388575992 328 F>Y No EVA
rs3388582164 337 D>H No EVA
rs3392112858 391 H>Q No EVA
rs3388578744 425 Q>* No EVA
rs3388577030 431 R>S No EVA
rs3388581355 435 E>V No EVA

No associated diseases with Q8R071

No regional properties for Q8R071

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q8R071

Functions

Description
EC Number 2.7.1.127 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
calmodulin-dependent protein kinase activity Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.
inositol hexakisphosphate kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown.
inositol-1,4,5-trisphosphate 3-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+).
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
small GTPase binding Binding to a small monomeric GTPase.

10 GO annotations of biological process

Name Definition
actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
cellular response to calcium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
dendritic spine maintenance The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
inositol metabolic process The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.
inositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of dendritic spine morphogenesis Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
regulation of synaptic plasticity A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
response to calcium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P27987 ITPKB Inositol-trisphosphate 3-kinase B Homo sapiens (Human) PR
P23677 ITPKA Inositol-trisphosphate 3-kinase A Homo sapiens (Human) PR
Q96DU7 ITPKC Inositol-trisphosphate 3-kinase C Homo sapiens (Human) PR
Q6PD10 Ip6k1 Inositol hexakisphosphate kinase 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MTLPGRPTGM ARPRGAGPCS PGLERAPRRS VGELRLLFEA RCAAVAAAAA AGEPRARGAK
70 80 90 100 110 120
RRGGQVPNGL PRAAPAPVIP QLTVTSEEDV TPASPGPPDQ EGNWLPAAGS HLQQPRRLST
130 140 150 160 170 180
SSLSSTGSSS LLEDSEDDLL SDSESRSRGN VQLETSEDVG QKSHWQKIRT MVNLPVMSPF
190 200 210 220 230 240
RKRYSWVQLA GHTGSFKAAG TSGLILKRSS EPEHYCLVRL MADVLRGCVP AFHGIVERDG
250 260 270 280 290 300
ESYLQLQDLL DGFDGPCVLD CKMGVRTYLE EELTKARERP KLRKDMYKKM LAVDPEAPTE
310 320 330 340 350 360
EEHAQRAVTK PRYMQWREGI SSSTTLGFRI EGIKKADGSC STDFKTTRSR EQVTRVFEEF
370 380 390 400 410 420
MQGDAEVLRR YLNRLQQIRD TLEISDFFRR HEVIGSSLLF VHDHCHRAGV WLIDFGKTTP
430 440 450
LPDGQILDHR RPWEEGNRED GYLLGLDNLI GILASLAER