AiPD: Autoinhibited Protein Database

P23677

Gene name	ITPKA
Protein name	Inositol-trisphosphate 3-kinase A
Names	Inositol 1,4,5-trisphosphate 3-kinase A, IP3 3-kinase A, IP3K A, InsP 3-kinase A
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3706
EC number	2.7.1.127: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-54 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for P23677

Entry ID	Method	Resolution	Chain	Position	Source
1W2C	X-ray	195 A	A/B	197-461	PDB
1W2D	X-ray	194 A	A/B	197-461	PDB
1W2F	X-ray	180 A	A/B	188-461	PDB
4UPU	X-ray	234 A	B	158-183	PDB
AF-P23677-F1	Predicted				AlphaFoldDB

354 variants for P23677

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1420031473 CA391833835	5	G>R		No	ClinGen Ensembl
rs1160641925 CA391833847	5	G>V		No	ClinGen TOPMed
CA391833916 rs1458860293	8	T>M		No	ClinGen TOPMed
rs1595446812 CA391833931	9	G>D		No	ClinGen Ensembl
rs1032315539 CA269709479	10	M>V		No	ClinGen TOPMed
CA391833997 rs1450723667	11	A>E		No	ClinGen gnomAD
rs1264995002 CA391833981	11	A>P		No	ClinGen TOPMed gnomAD
rs1247004477 CA391834050	14	G>R		No	ClinGen TOPMed
rs895124797 CA269709485	15	G>D		No	ClinGen TOPMed gnomAD
CA391834094 rs895124797	15	G>V		No	ClinGen TOPMed gnomAD
rs1463426637 CA391834101	16	A>T		No	ClinGen TOPMed
CA391834114 rs1247333500	16	A>V		No	ClinGen TOPMed
rs1275920628 CA391834146	18	P>S		No	ClinGen TOPMed
rs1218236059 CA391834266	21	P>L		No	ClinGen TOPMed
rs1345287123 CA391834278	22	G>R		No	ClinGen TOPMed
CA391834344 rs1471342827	25	R>W		No	ClinGen TOPMed gnomAD
rs1025177718 CA269709494	26	A>D		No	ClinGen TOPMed
CA391834528 rs1437933816	32	G>R		No	ClinGen TOPMed
CA269709502 rs998883504	33	E>G		No	ClinGen Ensembl
CA269709503 rs970988792	35	R>C		No	ClinGen TOPMed gnomAD
CA391834778 rs1447397998	39	E>Q		No	ClinGen TOPMed
rs1235172306 CA391835051	45	V>A		No	ClinGen TOPMed
rs1208833842 CA391835085	47	A>T		No	ClinGen TOPMed
CA269709505 rs1015048644	49	A>V		No	ClinGen TOPMed
CA269709508 rs961130085	54	P>S		No	ClinGen TOPMed
CA391835311 rs1335566420	55	R>G		No	ClinGen gnomAD
rs974245350 CA269709515	55	R>Q		No	ClinGen TOPMed
rs1335566420 CA391835306	55	R>W		No	ClinGen gnomAD
CA391835335 rs1595446870	56	A>T		No	ClinGen Ensembl
CA7491919 rs758741387	57	R>C		No	ClinGen ExAC gnomAD
CA391835393 rs1361211061	58	G>W		No	ClinGen gnomAD
CA391835408 rs1284190693	59	A>T		No	ClinGen TOPMed
CA391835455 rs919718055	61	R>G		No	ClinGen TOPMed gnomAD
CA269709526 rs919718055	61	R>W		No	ClinGen TOPMed gnomAD
rs932292229 CA269709534	62	R>P		No	ClinGen TOPMed
rs985156674 CA269709538	64	G>E		No	ClinGen TOPMed
TCGA novel	64	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA391835558 rs1369671869	66	V>D		No	ClinGen TOPMed
CA391835575 rs1290484206	67	P>S		No	ClinGen gnomAD
rs1290484206 CA391835569	67	P>T		No	ClinGen gnomAD
CA7491920 rs780411374	68	N>K		No	ClinGen ExAC gnomAD
rs1489820008 CA391835615	68	N>S		No	ClinGen gnomAD
CA391835630 rs1409299579	69	G>R		No	ClinGen TOPMed gnomAD
CA269709539 rs17855517	71	P>Q		No	ClinGen Ensembl
rs1250913885 CA391835683	71	P>S		No	ClinGen gnomAD
CA391835711 rs1179447802	72	R>L		No	ClinGen gnomAD
rs747448490 CA7491921	72	R>W		No	ClinGen ExAC TOPMed gnomAD
CA391835725 rs1245174788	73	A>P		No	ClinGen gnomAD
rs1445533783 CA391835735	73	A>V		No	ClinGen TOPMed gnomAD
CA391835774 rs1383471747	75	P>S		No	ClinGen TOPMed gnomAD
CA391835771 rs1383471747	75	P>T		No	ClinGen TOPMed gnomAD
CA391835849 rs1169028159	77	P>L		No	ClinGen gnomAD
rs1396459937 CA391835869	78	V>A		No	ClinGen gnomAD
rs1339172553 CA391835941	81	Q>H		No	ClinGen gnomAD
CA391835937 rs1595446906	81	Q>R		No	ClinGen Ensembl
rs1384535827 CA391835966	83	T>S		No	ClinGen TOPMed gnomAD
CA391835980 rs1313661702	84	V>L		No	ClinGen gnomAD
CA391835975 rs1313661702	84	V>M		No	ClinGen gnomAD
TCGA novel	87	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA391836057 rs1229469586	88	E>Q		No	ClinGen gnomAD
CA391836100 rs1251787559	89	P>L		No	ClinGen gnomAD
CA269709561 rs943936402	92	P>L		No	ClinGen TOPMed gnomAD
CA391836187 rs1244820358	92	P>S		No	ClinGen gnomAD
rs1241309513 CA391836285	95	S>R		No	ClinGen gnomAD
CA391836356 rs1430349720	98	P>T		No	ClinGen gnomAD
CA391836379 rs1372990024	99	P>L		No	ClinGen gnomAD
rs1460976511 CA391836411	101	R>Q		No	ClinGen gnomAD
CA391836423 rs1595446928	102	E>Q		No	ClinGen Ensembl
rs769801208 CA7491925	103	R>S		No	ClinGen ExAC gnomAD
CA7491927 rs749490354	104	D>H		No	ClinGen ExAC TOPMed gnomAD
rs749490354 CA391836476	104	D>N		No	ClinGen ExAC TOPMed gnomAD
rs993521389 CA269709599	105	C>S		No	ClinGen TOPMed
CA391836583 rs1335711435	107	P>L		No	ClinGen gnomAD
rs1469950762 CA391836573	107	P>S		No	ClinGen gnomAD
CA7491928 rs771836632	108	A>S		No	ClinGen ExAC gnomAD
CA7491929 rs546746124	108	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs867858165 CA269709618	110	G>D		No	ClinGen Ensembl
rs760607650 CA269709619	112	S>*		No	ClinGen ExAC TOPMed gnomAD
rs760607650 CA7491930	112	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1216731568 CA391836705	113	H>N		No	ClinGen gnomAD
rs1216731568 CA391836708	113	H>Y		No	ClinGen gnomAD
CA7491931 rs764104815	117	P>A		No	ClinGen ExAC gnomAD
CA269709635 rs867223462	117	P>L		No	ClinGen gnomAD
CA391836845 rs867223462	117	P>Q		No	ClinGen gnomAD
rs764104815 CA7491932	117	P>S		No	ClinGen ExAC gnomAD
rs761348946 CA7491933	118	R>C		No	ClinGen ExAC gnomAD
CA269709641 rs867834646	118	R>H		No	ClinGen Ensembl
rs868147683 CA269709642	119	R>H		No	ClinGen TOPMed
rs868147683 CA391836894	119	R>L		No	ClinGen TOPMed
CA269709646 rs948390791	120	L>F		No	ClinGen gnomAD
rs1261134098 CA391836917	120	L>R		No	ClinGen gnomAD
CA269709650 rs867208390	121	S>Y		No	ClinGen Ensembl
rs764675857 CA7491934	122	T>I		No	ClinGen ExAC gnomAD
rs867673755 CA269709651	123	S>*		No	ClinGen Ensembl
CA269709660 rs866191489	125	V>F		No	ClinGen Ensembl
rs936546733 CA269709665	127	S>C		No	ClinGen TOPMed gnomAD
CA391837082 rs936546733	127	S>Y		No	ClinGen TOPMed gnomAD
CA7491936 rs762516764	128	T>I		No	ClinGen ExAC TOPMed gnomAD
CA391837118 rs762516764	128	T>S		No	ClinGen ExAC TOPMed gnomAD
rs935741746 CA269709677	129	G>A		No	ClinGen Ensembl
CA391837133 rs1357059383	129	G>C		No	ClinGen gnomAD
CA269709694 rs867050760	131	S>*		No	ClinGen Ensembl
rs548345908 CA269709686	131	S>P		No	ClinGen Ensembl
CA269709709 rs867572453	133	L>M		No	ClinGen Ensembl
rs891659054 CA391837285	136	D>H		No	ClinGen TOPMed gnomAD
CA269709726 rs891659054	136	D>Y		No	ClinGen TOPMed gnomAD
CA7491938 rs538709322	141	L>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1299005065 CA391837420	142	L>Q		No	ClinGen gnomAD
CA391837432 rs1318889845	143	S>C		No	ClinGen TOPMed gnomAD
rs1260167330 CA391837507	145	S>T		No	ClinGen TOPMed gnomAD
CA391837559 rs755383322	147	S>N		No	ClinGen ExAC gnomAD
rs755383322 CA7491939	147	S>T		No	ClinGen ExAC gnomAD
TCGA novel	148	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA269709762 rs1012655266	148	R>W		No	ClinGen TOPMed gnomAD
CA7491940 rs781639159	149	S>G		No	ClinGen ExAC TOPMed gnomAD
CA269709779 rs559198390	150	R>H		No	ClinGen 1000Genomes gnomAD
rs756165323 CA7491942	153	V>L		No	ClinGen ExAC TOPMed
rs200462418 CA269709795	154	Q>H		No	ClinGen 1000Genomes TOPMed gnomAD
CA7491943 rs777726005	154	Q>R		No	ClinGen ExAC gnomAD
CA391837785 rs1385333476	155	L>P		No	ClinGen TOPMed
rs900437484 CA391837852	157	A>E		No	ClinGen TOPMed gnomAD
rs900437484 CA391837856	157	A>G		No	ClinGen TOPMed gnomAD
rs866857596 CA269709796	157	A>T		No	ClinGen Ensembl
rs900437484 CA269709801	157	A>V		No	ClinGen TOPMed gnomAD
CA391837866 rs1304489279	158	G>S		No	ClinGen gnomAD
CA391837937 rs1458766684	160	D>E		No	ClinGen gnomAD
CA391837951 rs1165812533	161	V>L		No	ClinGen TOPMed gnomAD
CA391837942 rs1165812533	161	V>M		No	ClinGen TOPMed gnomAD
CA7491944 rs142355356	162	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA391838023 rs1291515234	163	Q>H		No	ClinGen gnomAD
CA7491945 rs771049040	163	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA7491962 rs757455469	164	K>R		No	ClinGen ExAC TOPMed gnomAD
CA391842616 rs1595449682	165	N>T		No	ClinGen Ensembl
rs779238693 CA7491964	169	K>N		No	ClinGen ExAC TOPMed gnomAD
CA391842764 rs1472159576	171	R>G		No	ClinGen gnomAD
rs768513082 CA7491965	171	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1472159576 CA391842765	171	R>W		No	ClinGen gnomAD
rs1421557643 CA391842782	172	T>S		No	ClinGen gnomAD
rs546709838 CA7491966	173	M>T		No	ClinGen 1000Genomes ExAC gnomAD
CA269715877 rs1054115412	174	V>A		No	ClinGen Ensembl
rs1207892625 CA391842809	174	V>I		No	ClinGen TOPMed
CA391842832 rs1169615866	175	N>S		No	ClinGen gnomAD
rs1337678450 CA391842858	177	P>R		No	ClinGen gnomAD
rs769604495 COSM470608 CA7491968	177	P>S	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1445891888 CA391842874	179	I>V		No	ClinGen gnomAD
rs1301403301 CA391842896	180	S>N		No	ClinGen TOPMed
rs1272066935 CA391842942	183	K>E		No	ClinGen gnomAD
CA391843005 rs1363184478	185	R>H		No	ClinGen gnomAD
rs1363184478 CA391843004	185	R>L		No	ClinGen gnomAD
rs143540732 CA7491971	186	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA391843034 rs759196254	187	A>S		No	ClinGen ExAC gnomAD
CA7491973 rs759196254	187	A>T		No	ClinGen ExAC gnomAD
rs1204755856 CA391843060	188	W>*		No	ClinGen gnomAD
CA391843079 rs1263352826	189	V>M		No	ClinGen gnomAD
CA391843102 rs1274803250	190	Q>*		No	ClinGen gnomAD
rs1595449742 CA919539096	193	G>D		No	ClinGen Ensembl
rs1391421475 CA391843169	193	G>R		No	ClinGen TOPMed
CA391843207 rs1595449753	194	H>L		No	ClinGen Ensembl
CA391843196 rs1595449748	194	H>N		No	ClinGen Ensembl
rs1041422465 CA269715893	195	T>S		No	ClinGen Ensembl
rs1283264764 CA391843362	196	G>E		No	ClinGen gnomAD
rs1361431144 CA391843497	200	A>V		No	ClinGen gnomAD
rs1223155460 CA391843520	201	A>E		No	ClinGen TOPMed gnomAD
rs1223155460 CA391843522	201	A>V		No	ClinGen TOPMed gnomAD
rs367644899 CA269715992	202	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1595449849 CA391843544	202	G>C		No	ClinGen Ensembl
rs367644899 CA7491994	202	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA7491995 rs776947765	203	T>I		No	ClinGen ExAC gnomAD
CA391843575 rs1233653012	204	S>C		No	ClinGen gnomAD
CA391843592 rs1185212593	205	G>R		No	ClinGen TOPMed
CA391843609 rs1441712000	206	L>P		No	ClinGen TOPMed
CA7491996 rs762417088	207	I>L		No	ClinGen ExAC gnomAD
CA391843660 rs1156858246	210	R>H		No	ClinGen TOPMed gnomAD
rs765913011 CA7491997	212	S>A		No	ClinGen ExAC TOPMed gnomAD
rs758598040 CA7491999	213	E>A		No	ClinGen ExAC gnomAD
rs1389258083 CA391843725	213	E>D		No	ClinGen TOPMed gnomAD
rs1282730605 CA391843739	214	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs766479102 CA7492000	214	P>S		No	ClinGen ExAC gnomAD
rs1244525760 CA391843760	215	E>*		No	ClinGen TOPMed
CA391843796 rs1341556752	216	R>L		No	ClinGen TOPMed
rs755813046 CA7492003	217	Y>C		No	ClinGen ExAC gnomAD
CA391843877 rs1244932249	219	L>Q		No	ClinGen TOPMed gnomAD
rs1384399395 CA391843866	219	L>V		No	ClinGen gnomAD
CA391843898 rs1264769167	220	A>E		No	ClinGen TOPMed gnomAD
CA391843905 rs1264769167	220	A>V		No	ClinGen TOPMed gnomAD
rs1354233027 CA391843912	221	R>G		No	ClinGen TOPMed gnomAD
rs777632933 CA391843923	221	R>L		No	ClinGen ExAC TOPMed gnomAD
CA7492004 rs777632933	221	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA391843913 rs1354233027	221	R>W		No	ClinGen TOPMed gnomAD
rs749154650 CA7492005	223	M>T		No	ClinGen ExAC gnomAD
CA7492006 rs372904283	224	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7492007 rs778873563	224	A>V		No	ClinGen ExAC TOPMed gnomAD
CA7492009 rs569555910 COSM2270436	228	R>C	urinary_tract [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA7492010 rs774960957	229	G>S		No	ClinGen ExAC TOPMed gnomAD
CA269716047 rs981625537	230	C>F		No	ClinGen Ensembl
rs1471592303 CA391844152	233	A>D		No	ClinGen TOPMed
CA7492011 rs186875136	233	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs768837113 CA7492012	235	H>Y		No	ClinGen ExAC gnomAD
CA7492013 rs777132600	236	G>R		No	ClinGen ExAC gnomAD
rs1464739931 CA391844264	237	V>M		No	ClinGen gnomAD
CA391844351 rs1407906941	241	D>Y		No	ClinGen gnomAD
rs773894528 CA7492016	242	G>S		No	ClinGen ExAC gnomAD
rs1287341129 CA391844412	244	S>G		No	ClinGen TOPMed
rs1295546720 CA391844628	251	L>Q		No	ClinGen TOPMed
CA391844688 rs759804092	253	D>H		No	ClinGen ExAC TOPMed gnomAD
CA7492020 rs759804092	253	D>N		No	ClinGen ExAC TOPMed gnomAD
rs146892879 CA7492022	256	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA391844776 rs1461982946	256	D>H		No	ClinGen gnomAD
rs1254180479 CA391844816 CA391844805	257	G>R		No	ClinGen TOPMed gnomAD
CA391844913 rs1406221003	261	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA269716099 rs201247256	265	M>I		No	ClinGen 1000Genomes
CA391845310 rs1447811516	276	T>I		No	ClinGen gnomAD
rs1374806005 CA391845353	279	R>C		No	ClinGen gnomAD
rs775636995 CA7492057	279	R>L		No	ClinGen ExAC gnomAD
rs1291192698 CA391845368	280	E>A		No	ClinGen gnomAD
CA391845387 rs1321707987	281	R>L		No	ClinGen gnomAD
rs1321707987 CA391845384	281	R>Q		No	ClinGen gnomAD
rs867711236 COSM1211091 CA269716194	281	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
CA7492058 rs560905871	282	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1253456640 CA391845431	285	R>W		No	ClinGen gnomAD
CA269716201 rs373484451 CA391845454	286	K>N		No	ClinGen ESP
rs762706476 CA7492061	288	M>L		No	ClinGen ExAC gnomAD
CA391845497 rs1434124614	289	Y>S		No	ClinGen gnomAD
TCGA novel	290	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7492062 rs766307880	292	M>I		No	ClinGen ExAC gnomAD
CA7492063 rs751480830	293	L>V		No	ClinGen ExAC gnomAD
TCGA novel	300	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752327452 CA7492066	301	T>M		No	ClinGen ExAC TOPMed gnomAD
rs752327452 CA7492067	301	T>R		No	ClinGen ExAC TOPMed gnomAD
CA391845641 rs1166305288	302	E>G		No	ClinGen TOPMed
rs749639486 CA7492069	303	E>K		No	ClinGen ExAC TOPMed gnomAD
rs757597248 CA7492070	306	A>G		No	ClinGen ExAC TOPMed gnomAD
CA391845690 rs1454636944	306	A>S		No	ClinGen gnomAD
CA269716219 rs757597248	306	A>V		No	ClinGen ExAC TOPMed gnomAD
rs993563205 CA269716222	307	Q>E		No	ClinGen TOPMed
rs1227123354 CA391845714	308	R>C		No	ClinGen gnomAD
CA7492071 rs779430196	308	R>H		No	ClinGen ExAC gnomAD
rs1198465863 CA391845725	309	A>D		No	ClinGen gnomAD
CA391845721 rs1318995469	309	A>T		No	ClinGen gnomAD
rs772076582 COSM1372778 CA7492073	310	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA7492074 rs150465612	313	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1482857957 CA391845773	313	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs150465612 CA7492075	313	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	314	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	314	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA269716238 rs77491131	320	E>G		No	ClinGen Ensembl
CA391845883 rs1272626999	321	G>V		No	ClinGen TOPMed
rs1421755663 CA391845900	323	S>G		No	ClinGen gnomAD
rs776759495 CA7492077	323	S>T		No	ClinGen ExAC gnomAD
rs1358681313 CA391845923	325	S>G		No	ClinGen gnomAD
rs1445959211 CA391845952	327	T>I		No	ClinGen gnomAD
CA391845944 rs1595450372	327	T>P		No	ClinGen Ensembl
rs1218403357 CA391845972	329	G>D		No	ClinGen gnomAD
rs1216110209 CA391845989	330	F>L		No	ClinGen TOPMed
CA391846031 rs1315619821	334	G>V		No	ClinGen gnomAD
rs762767366 CA7492078	335	I>V		No	ClinGen ExAC TOPMed gnomAD
rs747062181 CA7492095	338	A>V		No	ClinGen ExAC gnomAD
rs758806990 CA269716347	339	D>E		No	ClinGen gnomAD
TCGA novel	339	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7492097 rs781426159	340	G>C		No	ClinGen ExAC gnomAD
CA7492098 rs748330626	341	S>Y		No	ClinGen ExAC gnomAD
rs1323392557 CA391846476	349	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
COSM961421 CA391846481 rs574486119	350	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA391846487 rs1438281000	350	R>Q		No	ClinGen gnomAD
CA391846508 rs1595450838	351	S>T		No	ClinGen Ensembl
CA391846555 rs1481479997	353	E>G		No	ClinGen gnomAD
TCGA novel	354	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772110668 CA7492102	355	V>M		No	ClinGen ExAC TOPMed gnomAD
CA391846667 rs1377038982	357	R>P		No	ClinGen gnomAD
rs1238851693 CA391846730	360	E>K		No	ClinGen gnomAD
TCGA novel	361	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775606125 CA7492103	364	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs775606125 CA391846819	364	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA7492104 rs760217128	364	Q>R		No	ClinGen ExAC gnomAD
rs1387794613 CA391846844	365	G>R		No	ClinGen TOPMed
rs553718435 CA7492105	367	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs761372084 CA7492107	368	E>D		No	ClinGen ExAC gnomAD
CA7492106 rs145328827	368	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA391847269 rs755436645	372	R>L		No	ClinGen ExAC TOPMed gnomAD
rs755436645 CA391847267	372	R>P		No	ClinGen ExAC TOPMed gnomAD
rs755436645 CA7492131	372	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA391847329 rs1595451257	375	N>T		No	ClinGen Ensembl
CA391847350 rs1345755400	376	R>C		No	ClinGen TOPMed gnomAD
CA391847344 rs1345755400	376	R>S		No	ClinGen TOPMed gnomAD
CA7492133 rs752693895	379	Q>R		No	ClinGen ExAC gnomAD
rs1262983833 CA391847510	381	R>L		No	ClinGen gnomAD
TCGA novel	381	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA269716455 rs867967198	382	D>E		No	ClinGen Ensembl
rs1266290276 CA391847514	382	D>N		No	ClinGen TOPMed gnomAD
CA391847519 rs1266290276	382	D>Y		No	ClinGen TOPMed gnomAD
rs756255009 CA7492134	383	T>A		No	ClinGen ExAC gnomAD
rs919023895 CA269716458	383	T>I		No	ClinGen TOPMed gnomAD
rs1167832017 CA391847596	385	E>K		No	ClinGen gnomAD
CA391847642 rs1284980653	386	V>A		No	ClinGen TOPMed
CA391847627 rs1466053235	386	V>I		No	ClinGen gnomAD
TCGA novel	388	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	389	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA391847736 rs1373552974	390	F>L		No	ClinGen gnomAD
TCGA novel	391	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201490754 CA7492136	392	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA391847821 rs1472258034	393	H>L		No	ClinGen gnomAD
CA391847851 rs1302979139	394	E>K		No	ClinGen TOPMed
rs767943853 CA7492171	395	V>M		No	ClinGen ExAC gnomAD
rs1457248710 CA391848119	397	G>R		No	ClinGen gnomAD
rs1324079543 CA391848149	398	S>N		No	ClinGen gnomAD
rs1447523908 CA391848185	399	S>L		No	ClinGen gnomAD
CA7492174 rs764759144	400	L>F		No	ClinGen ExAC gnomAD
rs1230579405 CA391848300	403	V>M		No	ClinGen gnomAD
CA391848326 rs757453229	405	D>N		No	ClinGen ExAC gnomAD
CA7492176 rs757453229	405	D>Y		No	ClinGen ExAC gnomAD
CA391848361 rs1376903907	406	H>P		No	ClinGen TOPMed
CA7492177 rs765516106	406	H>Q		No	ClinGen ExAC gnomAD
CA391848359 rs1231866883	406	H>Y		No	ClinGen TOPMed gnomAD
CA7492178 rs750682391	408	H>R		No	ClinGen ExAC TOPMed gnomAD
rs754673558 CA7492179	409	R>C		No	ClinGen ExAC TOPMed gnomAD
rs754673558 CA391848437	409	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1183489890 CA391848470	410	A>V		No	ClinGen gnomAD
CA7492182 rs376720541	411	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA7492181 rs376720541	411	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1595451626 CA391848509	412	V>G		No	ClinGen Ensembl
rs1316136057 CA391848501	412	V>L		No	ClinGen gnomAD
CA391848498 rs1316136057	412	V>M		No	ClinGen gnomAD
CA391848588 rs1162534117	415	I>V		No	ClinGen TOPMed gnomAD
CA391848675 rs1170029913	418	G>R		No	ClinGen TOPMed gnomAD
CA7492186 rs778377389	421	T>A		No	ClinGen ExAC gnomAD
CA269716511 rs1007833063	421	T>M		No	ClinGen TOPMed
CA7492187 rs745545484	422	P>R		No	ClinGen ExAC gnomAD
rs1379096344 CA391848751	422	P>S		No	ClinGen gnomAD
rs375904304 CA391848794	424	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs375904304 CA7492188	424	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA391848787 rs1319535306	424	P>S		No	ClinGen gnomAD
rs760994275 CA7492190	425	D>G		No	ClinGen ExAC gnomAD
CA7492189 rs775913660	425	D>N		No	ClinGen ExAC gnomAD
CA391848818 rs1211635872	426	G>S		No	ClinGen gnomAD
CA7492193 rs761938864	433	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA391849029 rs1478253145	434	P>L		No	ClinGen gnomAD
CA391849122 rs1273527132	438	G>D		No	ClinGen TOPMed
CA269716525 rs370243619	443	G>C		No	ClinGen ESP TOPMed gnomAD
CA391849238 rs370243619	443	G>S		No	ClinGen ESP TOPMed gnomAD
CA391849374 rs756697444	449	D>G		No	ClinGen ExAC gnomAD
CA269716532 rs753794514	449	D>H		No	ClinGen ExAC TOPMed gnomAD
CA7492202 rs756697444	449	D>V		No	ClinGen ExAC gnomAD
CA7492201 rs753794514	449	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs771734285 CA7492205	452	I>M		No	ClinGen ExAC gnomAD
CA7492204 rs200665977	452	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA7492206 rs137962153	453	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs137962153 CA391849477	453	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs747341736 CA7492207	454	I>V		No	ClinGen ExAC
CA391849499 rs769168955	455	L>V		No	ClinGen ExAC gnomAD
CA269716541 rs1043317903	456	A>G		No	ClinGen TOPMed
rs762417213 CA7492210	458	L>M		No	ClinGen ExAC TOPMed gnomAD
CA391849621 rs1476213878	459	A>D		No	ClinGen TOPMed
rs906024508 CA269716545	459	A>T		No	ClinGen TOPMed
TCGA novel	460	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with P23677

No regional properties for P23677

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P23677

Functions

		Description
EC Number	2.7.1.127	Phosphotransferases with an alcohol group as acceptor
Subcellular Localization	Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic spine	A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calmodulin binding	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
calmodulin-dependent protein kinase activity	Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.
inositol hexakisphosphate kinase activity	Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown.
inositol-1,4,5-trisphosphate 3-kinase activity	Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+).
kinase activity	Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
small GTPase binding	Binding to a small monomeric GTPase.

11 GO annotations of biological process

Name	Definition
actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
cellular response to calcium ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
dendritic spine maintenance	The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
inositol metabolic process	The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.
inositol phosphate biosynthetic process	The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
phosphatidylinositol phosphate biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphorylation	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of dendritic spine morphogenesis	Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
regulation of synaptic plasticity	A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
response to calcium ion	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q96DU7	ITPKC	Inositol-trisphosphate 3-kinase C	Homo sapiens (Human)	PR
Q92551	IP6K1	Inositol hexakisphosphate kinase 1	Homo sapiens (Human)	PR
P27987	ITPKB	Inositol-trisphosphate 3-kinase B	Homo sapiens (Human)	PR
Q8R071	Itpka	Inositol-trisphosphate 3-kinase A	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MTLPGGPTGM	ARPGGARPCS	PGLERAPRRS	VGELRLLFEA	RCAAVAAAAA	AGEPRARGAK
70	80	90	100	110	120
RRGGQVPNGL	PRAPPAPVIP	QLTVTAEEPD	VPPTSPGPPE	RERDCLPAAG	SSHLQQPRRL
130	140	150	160	170	180
STSSVSSTGS	SSLLEDSEDD	LLSDSESRSR	GNVQLEAGED	VGQKNHWQKI	RTMVNLPVIS
190	200	210	220	230	240
PFKKRYAWVQ	LAGHTGSFKA	AGTSGLILKR	CSEPERYCLA	RLMADALRGC	VPAFHGVVER
250	260	270	280	290	300
DGESYLQLQD	LLDGFDGPCV	LDCKMGVRTY	LEEELTKARE	RPKLRKDMYK	KMLAVDPEAP
310	320	330	340	350	360
TEEEHAQRAV	TKPRYMQWRE	GISSSTTLGF	RIEGIKKADG	SCSTDFKTTR	SREQVLRVFE
370	380	390	400	410	420
EFVQGDEEVL	RRYLNRLQQI	RDTLEVSEFF	RRHEVIGSSL	LFVHDHCHRA	GVWLIDFGKT
430	440	450	460
TPLPDGQILD	HRRPWEEGNR	EDGYLLGLDN	LIGILASLAE	R