Q8QZR5
Gene name |
Gpt (Gpt1) |
Protein name |
Alanine aminotransferase 1 |
Names |
ALT1, Glutamate pyruvate transaminase 1, GPT 1, Glutamic--alanine transaminase 1, Glutamic--pyruvic transaminase 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:76282 |
EC number |
2.6.1.2: Transaminases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8QZR5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8QZR5-F1 | Predicted | AlphaFoldDB |
40 variants for Q8QZR5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389358802 | 30 | V>M | No | EVA | |
| rs3389366707 | 35 | Y>* | No | EVA | |
| rs3389379048 | 65 | R>H | No | EVA | |
| rs3389331350 | 85 | V>I | No | EVA | |
| rs3389358823 | 86 | L>Q | No | EVA | |
| rs3389363505 | 94 | L>I | No | EVA | |
| rs3404733905 | 104 | A>D | No | EVA | |
| rs3389331432 | 111 | I>F | No | EVA | |
| rs3389368299 | 125 | I>F | No | EVA | |
| rs3389384958 | 152 | N>K | No | EVA | |
| rs3389331340 | 159 | G>W | No | EVA | |
| rs3389379103 | 163 | A>P | No | EVA | |
| rs49606778 | 178 | A>E | No | EVA | |
| rs3389368242 | 187 | P>S | No | EVA | |
| rs3389331353 | 215 | A>D | No | EVA | |
| rs3389338816 | 221 | L>M | No | EVA | |
| rs3405754331 | 242 | P>L | No | EVA | |
| rs3389366692 | 244 | N>Y | No | EVA | |
| rs387860546 | 271 | A>T | No | EVA | |
| rs3389379051 | 283 | G>V | No | EVA | |
| rs3389358825 | 378 | E>D | No | EVA | |
| rs3406397418 | 384 | A>P | No | EVA | |
| rs3406255333 | 385 | E>D | No | EVA | |
| rs3406000019 | 385 | E>V | No | EVA | |
| rs3405422031 | 386 | L>Q | No | EVA | |
| rs3405422104 | 387 | A>P | No | EVA | |
| rs864285288 | 400 | A>G | No | EVA | |
| rs3405999998 | 402 | G>R | No | EVA | |
| rs3389370620 | 404 | R>H | No | EVA | |
| rs3389368249 | 409 | Q>* | No | EVA | |
| rs230707589 | 417 | Q>R | No | EVA | |
| rs249631307 | 418 | I>M | No | EVA | |
| rs3389372389 | 424 | A>T | No | EVA | |
| rs244243275 | 430 | D>E | No | EVA | |
| rs3389366660 | 435 | P>S | No | EVA | |
| rs3389384956 | 445 | E>V | No | EVA | |
| rs3389363868 | 452 | V>M | No | EVA | |
| rs3389370581 | 453 | P>L | No | EVA | |
| rs3389384922 | 462 | G>D | No | EVA | |
| rs3389368288 | 482 | E>D | No | EVA |
No associated diseases with Q8QZR5
1 regional properties for Q8QZR5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Aminotransferase, class I/classII | 86 - 484 | IPR004839 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.6.1.2 | Transaminases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| L-alanine:2-oxoglutarate aminotransferase activity | Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| biosynthetic process | The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. |
| cellular response to insulin stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. |
| L-alanine catabolic process | The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid. |
| positive regulation of gluconeogenesis | Any process that activates or increases the frequency, rate or extent of gluconeogenesis. |
| response to starvation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASQRNDRIQ | ASRNGLKGKV | LTLDTMNPCV | RRVEYAVRGP | IVQRALELEQ | ELRQGVKKPF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TEVIRANIGD | AQAMGQRPIT | FFRQVLALCV | YPNLLSSPDF | PEDAKRRAER | ILQACGGHSL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GAYSISSGIQ | PIREDVAQYI | ERRDGGIPAD | PNNIFLSTGA | SDAIVTMLKL | LVAGEGRART |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GVLIPIPQYP | LYSAALAELD | AVQVDYYLDE | ERAWALDIAE | LRRALCQARD | RCCPRVLCVI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NPGNPTGQVQ | TRECIEAVIR | FAFEEGLFLM | ADEVYQDNVY | AEGSQFHSFK | KVLTEMGPPY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ATQQELASFH | SVSKGYMGEC | GFRGGYVEVV | NMDAEVQKQM | AKLMSVRLCP | PVPGQALMGM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VVSPPTPSEP | SFKQFQAERQ | EVLAELAAKA | KLTEQVFNEA | PGIRCNPVQG | AMYSFPQIQL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PLKAVQRAQD | LGLAPDMFFC | LCLLEETGIC | VVPGSGFGQQ | EGTYHFRMTI | LPPMEKLRVL |
| 490 | |||||
| LEKLRHFHAK | FTHEYS |