AiPD: Autoinhibited Protein Database

Gene name	Gpt2 (Aat2)
Protein name	Alanine aminotransferase 2
Names	ALT2, Glutamate pyruvate transaminase 2, GPT 2, Glutamic--alanine transaminase 2, Glutamic--pyruvic transaminase 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:108682
EC number	2.6.1.2: Transaminases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-50 (Predicted disordered autoinhibitory region) PR

1-50 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BGT5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3398909303	36	K>M	No	EVA
rs3399431930	42	S>R	No	EVA
rs3388967523	91	I>N	No	EVA
rs3389003178	118	Y>N	No	EVA
rs3388994866	150	Y>H	No	EVA
rs3388995950	214	Q>R	No	EVA
rs3388994707	269	G>R	No	EVA
rs3388994622	274	Q>K	No	EVA
rs3388994672	289	W>R	No	EVA
rs3388995946	290	E>G	No	EVA
rs3388985291	329	N>D	No	EVA
rs3388997939	342	Y>C	No	EVA
rs3389003129	345	E>K	No	EVA
rs3388994871	346	C>S	No	EVA
rs3388998512	351	G>S	No	EVA
rs3389002290	367	V>L	No	EVA
rs3388991478	406	E>V	No	EVA
rs3388967493	417	K>Q	No	EVA
rs3389003177	434	L>V	No	EVA
rs3388967518	464	F>S	No	EVA
rs3399379301	467	M>I	No	EVA
rs3388994841	480	G>D	No	EVA
rs3388973896	489	T>S	No	EVA
rs3388998438	500	V>M	No	EVA
rs219981505	501	D>E	No	EVA

Type	Name	Position	InterPro Accession
domain	Aminotransferase, class I/classII	112 - 499	IPR004839

		Description
EC Number	2.6.1.2	Transaminases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
L-alanine:2-oxoglutarate aminotransferase activity	Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
pyridoxal phosphate binding	Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

Name	Definition
2-oxoglutarate metabolic process	The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
biosynthetic process	The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
L-alanine catabolic process	The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.
L-alanine metabolic process	The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.
positive regulation of gluconeogenesis	Any process that activates or increases the frequency, rate or extent of gluconeogenesis.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8QZR5	Gpt	Alanine aminotransferase 1	Mus musculus (Mouse)	PR
P25409	Gpt	Alanine aminotransferase 1	Rattus norvegicus (Rat)	PR
Q28DB5	gpt2	Alanine aminotransferase 2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR