Q28DB5

PR
Gene name
gpt2 (TEgg035f04.1)
Protein name
Alanine aminotransferase 2
Names
ALT2, Glutamate pyruvate transaminase 2, GPT 2, Glutamic--alanine transaminase 2, Glutamic--pyruvic transaminase 2
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:549559
EC number
2.6.1.2: Transaminases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q28DB5

Entry ID Method Resolution Chain Position Source
AF-Q28DB5-F1 Predicted AlphaFoldDB

No variants for Q28DB5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q28DB5

No associated diseases with Q28DB5

1 regional properties for Q28DB5

Type Name Position InterPro Accession
domain Aminotransferase, class I/classII 127 - 512 IPR004839

Functions

Description
EC Number 2.6.1.2 Transaminases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
L-alanine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

4 GO annotations of biological process

Name Definition
2-oxoglutarate metabolic process The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
L-alanine catabolic process The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.
L-alanine metabolic process The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8BGT5 Gpt2 Alanine aminotransferase 2 Mus musculus (Mouse) PR
Q8QZR5 Gpt Alanine aminotransferase 1 Mus musculus (Mouse) PR
P25409 Gpt Alanine aminotransferase 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MDSDLISSRC VWATWNVYNG RSLSGTPLAE RDGKVARKMS ENGTCNRILT LESMNPCIQK
70 80 90 100 110 120
VEYAVRGPIV IRAVELEKEL QQGVKKPFTE VIKANIGDAH AMGQKPITFL RQVSAICLYP
130 140 150 160 170 180
ELMNDNKFPE DVKQKAARIL QACGGHSIGA YSASQGIEVI RQDVAKYIER RDGGIQSDPN
190 200 210 220 230 240
NIYLSTGASD SIVTMLKLLV SGQGKSRTGV LIPIPQYPLY SAALAELNAV QVNYYLDEEN
250 260 270 280 290 300
CWALDINELR RSLTEARKHC DPKVLCIINP GNPTGQVQSR KCIEDVIRFA AEENLFLMAD
310 320 330 340 350 360
EVYQDNVYAK GCTFHSFKKV LFEMGPKYSE TVELASFHST SKGYMGECGF RGGYMEVINM
370 380 390 400 410 420
DPAVKQQLTK LVSVRLCPPV PGQALLDVIV NPPKPGEPSY KQFMAEKQAV LGNLAEKARL
430 440 450 460 470 480
TEEILNQSPG IRCNPVQGAM YSFPRIHIPE KAIKLAQAEG QAPDMFFCMK LLEETGICVV
490 500 510 520
PGSGFGQREG THHFRMTILP PTDKLKSLLE RLKDFHQKFT EEYS