Q8QZR3
Gene name |
Ces2a |
Protein name |
Pyrethroid hydrolase Ces2a |
Names |
Carboxylic ester hydrolase 2A, carboxylesterase 2A |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:102022 |
EC number |
3.1.1.88: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8QZR3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8QZR3-F1 | Predicted | AlphaFoldDB |
46 variants for Q8QZR3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs241970985 | 10 | L>Q | No | EVA | |
| rs222877485 | 15 | C>S | No | EVA | |
| rs3389003030 | 39 | G>R | No | EVA | |
| rs3389007481 | 52 | K>R | No | EVA | |
| rs585934177 | 70 | L>P | No | EVA | |
| rs49466976 | 79 | P>A | No | EVA | |
| rs51035708 | 90 | S>T | No | EVA | |
| rs6314041 | 102 | N>S | No | EVA | |
| rs582324558 | 105 | D>V | No | EVA | |
| rs579405941 | 105 | D>Y | No | EVA | |
| rs215840122 | 106 | A>V | No | EVA | |
| rs228346844 | 108 | E>G | No | EVA | |
| rs3389005886 | 134 | Q>* | No | EVA | |
| rs3399640067 | 147 | G>R | No | EVA | |
| rs579521920 | 152 | V>I | No | EVA | |
| rs583181557 | 162 | K>E | No | EVA | |
| rs3388985203 | 177 | R>H | No | EVA | |
| rs587076302 | 180 | V>I | No | EVA | |
| rs3413127710 | 203 | A>T | No | EVA | |
| rs214463034 | 205 | R>H | No | EVA | |
| rs222181043 | 260 | D>G | No | EVA | |
| rs580619531 | 308 | M>I | No | EVA | |
| rs584371233 | 311 | A>G | No | EVA | |
| rs39301914 | 327 | T>A | No | EVA | |
| rs258020682 | 345 | C>Y | No | EVA | |
| rs227005215 | 349 | V>I | No | EVA | |
| rs246965837 | 351 | M>T | No | EVA | |
| rs254955923 | 352 | F>V | No | EVA | |
| rs212621553 | 367 | L>V | No | EVA | |
| rs235788682 | 373 | N>T | No | EVA | |
| rs36687170 | 377 | R>Q | No | EVA | |
| rs3389010411 | 450 | S>* | No | EVA | |
| rs3389010363 | 455 | D>G | No | EVA | |
| rs221820098 | 475 | L>F | No | EVA | |
| rs251949172 | 485 | M>R | No | EVA | |
| rs220987109 | 486 | M>V | No | EVA | |
| rs36318585 | 496 | N>H | No | EVA | |
| rs583912833 | 506 | S>Y | No | EVA | |
| rs37125265 | 512 | H>Q | No | EVA | |
| rs3412839929 | 514 | E>K | No | EVA | |
| rs232036511 | 520 | D>N | No | EVA | |
| rs3389010377 | 522 | Q>H | No | EVA | |
| rs3388985137 | 523 | P>R | No | EVA | |
| rs3388955629 | 545 | I>F | No | EVA | |
| rs581421081 | 550 | G>S | No | EVA | |
| rs3389001928 | 552 | Q>K | No | EVA |
No associated diseases with Q8QZR3
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.88 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity | Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate. |
| carboxylic ester hydrolase activity | Catalysis of the hydrolysis of a carboxylic ester bond. |
| trans-permethrin hydrolase activity | Catalysis of the reaction: (-)-trans-permethrin + H2O <=> H+ + (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| prostaglandin metabolic process | The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. |
| protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPLARLPGWL | CVVACGLLLL | LQHVHGQDSA | SPIRNTHRGQ | VRGSFVHVKD | TKSGVHAFLG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IPFAKPPVGL | LRFAPPEDPE | PWSGVRDGTS | QPAMCLQPDI | MNLEDAKEMN | LILPPISMSE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DCLYLNIYTP | THAQEGSNLP | VMVWIHGGGL | VVGSASMNDV | SKLAATEEIV | IVAIQYRLGV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LGFFSTGDQH | ARGNWGYLDQ | VAALRWVQKN | IAYFGGNRDR | VTIFGVSAGG | TSVSSHILSP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MSKGLFHGAI | MQSGVALLPD | LISDTSEVVY | KTVANLSGCE | ATDSEALIHC | LRAKSKQEIL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AINQVFKMIP | AVVDGEFLPK | HPQELLTSMD | FHPVPSIIGV | NTDECGWGVP | MFMGLDHIIK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NITRETLPAV | LKNTAARMML | PPECSHLLVE | EYMGDTEDPE | TLQAQFREML | GDFMFVIPAL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QVAHFQRSQA | PVYFYEFQHL | SSFIKHVRPS | HVKADHGDDV | AFVFGSYLWD | MNLDLTEEEE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LLKRMMMKYW | ANFARNGNPN | SEGLPSWPVL | DHDEQYLQLD | TQPAVGRALK | ARRLQFWTKT |
| 550 | |||||
| LPQKIQELKG | SQDKHAEL |