P08171

PR
Gene name
Est-6 (EST6, CG6917)
Protein name
Esterase-6
Names
Est-6, Carboxylic-ester hydrolase 6, Carboxylesterase-6
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG6917
EC number
3.1.1.1: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

478-544 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P08171

Entry ID Method Resolution Chain Position Source
5THM X-ray 215 A A 22-544 PDB
AF-P08171-F1 Predicted AlphaFoldDB

20 variants for P08171

Variant ID(s) Position Change Description Diseaes Association Provenance
10 I>T strain: 178.7, 357F, 517S, Bar-F-77F, Bar-F-79F, Bar-F-96S, DPF-13, DPF-30, DPF-82.1, EM-10, F-274F, F-517F, F-1461S, MA-4.4 and Zim-F-H31 [UniProt] No
24 T>I strain: 178.7, 377F, 357F, 517S, Bar-F-79F, DPF-13, DPF-30, DPF-82.1, EM-10, F-274F, F-517F, F-775F, F-1461S, MA-4.4, Ven-S-13F, Zim-F-H27, Zim-F-H31, Zim-F-S11, Zim-F-S18, Zim-F-S53, Zim-S-S2, Zim-S-S30 and Zim-S-S34 [UniProt] No
33 P>S strain: Zim-S-H13 [UniProt] No
58 T>I strain: 178.7, 357F, 517S, Bar-F-77F, Bar-F-79F, Bar-F-96S, DPF-13, DPF-30, DPF-82.1, EM-10, F-274F, F-1461S, MA-4.2, VC-805, Ven-S-1F, Ven-S-2F, Ven-S-3F, Ven-S-11F, Ven-S-21F, Zim-F-H31, Zim-F-S18 and Zim-S-S10 [UniProt] No
120 S>T strain: DPF-2 and 521S [UniProt] No
258 N>D strain: 178.7, 357F, 517S, 709.6, Bar-F-7F, Bar-F-77F, Bar-F-79F, Bar-F-93F, Bar-F-96S, DPF-13, DPF-30, DPF-46, DPF-77, DPF-82.1, EM-10, F-96S, F-274F, F-517F, F-531F, F-611F, F-775F, F-1461S, MA-4.2, Zim-F-H27, Zim-F-H31, Zim-F-S11, Zim-F-S18 and Zim-F-S53 [UniProt] No
268 T>A strain: 174F, 178.7, 357F, 517S, 709.6, Bar-F-7F, Bar-F-77F, Bar-F-79F, Bar-F-93F, Bar-F-96S, Bar-S-24F, Bar-S-60F, Bar-S-78F, Bar-S-89F, Bar-S-99F, Bar-S-95F, DPF-13, DPF-30, DPF-46, DPF-77, DPF-82.1, EM-10, F-96S, F-274F, F-517F, F-531F, S-549S, F-611F, F-775F, F-1461S, MA-4.2, S-114S, S-2588S, VC-815, Ven-S-1F, Ven-S-2F, Ven-S-3F, Ven-S-4F, Ven-S-11F, Ven-S-21F, Zim-F-H27, Zim-F-H31, Zim-F-S11, Zim-F-S18, Zim-F-S53, Zim-S-S34 and Zim-S-44F [UniProt] No
276 S>P strain: VC-805 [UniProt] No
309 A>V strain: Ven-S-13F [UniProt] No
356 I>T strain: F-775F [UniProt] No
363 E>D strain: F-775F [UniProt] No
371 Y>H strain: F-775F [UniProt] No
376 R>G strain: Zim-S-S34 [UniProt] No
394 E>D strain: Ven-S-13F and Zim-F-S18 [UniProt] No
397 G>R strain: US-255F [UniProt] No
409 L>V strain: 357F, 517S, Bar-F-7F, Bar-F-77F, Bar-F-79F, Bar-F-93F, Bar-F-96S, DPF-13, DPF-30, F-96S, F-274F, F-517F, F-1461S, S-114S, S-549S, S-2588S, VC-805, Ven-S-4F, Zim-S-S2, Zim-S-S30 and Zim-S-S34 [UniProt] No
441 V>I strain: Zim-F-S53 [UniProt] No
492 R>K strain: 94F, 174F, Bar-S-24F, Bar-S-89F, Bar-S-99F, Bar-S-95F, Bar-S-60F, F-531F, F-611F, MA-4.2, Zim-F-H27, Zim-F-S18 and Zim-S-44F [UniProt] No
500 D>N strain: Zim-F-S18, Zim-S-H32 and Zim-S-S2 [UniProt] No
508 S>A strain: 357F, 517S, Bar-F-79F, Bar-S-78F, DPF-13, DPF-30, F-96S, F-517F, F-1461S, MA-4.2, VC-805, Ven-S-1F, Ven-S-2F, Ven-S-3F, Ven-S-11F, Ven-S-21F and Zim-F-S11 [UniProt] No

No associated diseases with P08171

3 regional properties for P08171

Type Name Position InterPro Accession
domain Carboxylesterase, type B 28 - 535 IPR002018
conserved_site Carboxylesterase type B, conserved site 103 - 113 IPR019819
active_site Carboxylesterase type B, active site 196 - 211 IPR019826

Functions

Description
EC Number 3.1.1.1 Carboxylic ester hydrolases
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

4 GO annotations of molecular function

Name Definition
carboxylic ester hydrolase activity Catalysis of the hydrolysis of a carboxylic ester bond.
methyl indole-3-acetate esterase activity Catalysis of the reaction: methyl indole-3-acetate + H2O = indole-3-acetate + methanol + H+.
serine hydrolase activity Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
short-chain carboxylesterase activity Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms.

9 GO annotations of biological process

Name Definition
courtship behavior The behavior of an organism for the purpose of attracting sexual partners.
mating The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.
organic substance catabolic process The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon.
ovulation The release of a mature ovum/oocyte from an ovary.
pheromone biosynthetic process The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process.
regulation of female receptivity, post-mating Any process that modulates the receptiveness of a female to male advances subsequent to mating.
regulation of oviposition Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium.
sexual reproduction A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid).
sperm storage The retention of sperm by a female following mating.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P33438 Glt Glutactin Drosophila melanogaster (Fruit fly) PR
Q8QZR3 Ces2a Pyrethroid hydrolase Ces2a Mus musculus (Mouse) PR
10 20 30 40 50 60
MNYVGLGLII VLSCLWLGSN ASDTDDPLLV QLPQGKLRGR DNGSYYSYES IPYAEPPTGD
70 80 90 100 110 120
LRFEAPEPYK QKWSDIFDAT KTPVACLQWD QFTPGANKLV GEEDCLTVSV YKPKNSKRNS
130 140 150 160 170 180
FPVVAHIHGG AFMFGAAWQN GHENVMREGK FILVKISYRL GPLGFVSTGD RDLPGNYGLK
190 200 210 220 230 240
DQRLALKWIK QNIASFGGEP QNVLLVGHSA GGASVHLQML REDFGQLARA AFSFSGNALD
250 260 270 280 290 300
PWVIQKGARG RAFELGRNVG CESAEDSTSL KKCLKSKPAS ELVTAVRKFL IFSYVPFAPF
310 320 330 340 350 360
SPVLEPSDAP DAIITQDPRD VIKSGKFGQV PWAVSYVTED GGYNAALLLK ERKSGIVIDD
370 380 390 400 410 420
LNERWLELAP YLLFYRDTKT KKDMDDYSRK IKQEYIGNQR FDIESYSELQ RLFTDILFKN
430 440 450 460 470 480
STQESLDLHR KYGKSPAYAY VYDNPAEKGI AQVLANRTDY DFGTVHGDDY FLIFENFVRD
490 500 510 520 530 540
VEMRPDEQII SRNFINMLAD FASSDNGSLK YGECDFKDNV GSEKFQLLAI YIDGCQNRQH
VEFP