AiPD: Autoinhibited Protein Database

Q8N4P3

Gene name	HDDC3 (MESH1)
Protein name	Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
Names	HD domain-containing protein 3, Metazoan SpoT homolog 1, MESH1, Penta-phosphate guanosine-3'-pyrophosphohydrolase, (ppGpp)ase
Species	Homo sapiens (Human)
KEGG Pathway	hsa:374659
EC number	3.1.7.2: Diphosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-49 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

3 structures for Q8N4P3

Entry ID	Method	Resolution	Chain	Position	Source
3NR1	X-ray	190 A	A/B	2-179	PDB
5VXA	X-ray	210 A	A/B	1-179	PDB
AF-Q8N4P3-F1	Predicted				AlphaFoldDB

144 variants for Q8N4P3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA393889607 rs1041004690	4	E>K		No	ClinGen TOPMed
CA274799284 rs1041004690	4	E>Q		No	ClinGen TOPMed
rs781086745 CA393889597	5	A>E		No	ClinGen ExAC gnomAD
CA7742347 rs781086745	5	A>V		No	ClinGen ExAC gnomAD
CA393889590 rs1175532140	6	A>V		No	ClinGen TOPMed
CA7742344 rs777219665	10	E>*		No	ClinGen ExAC TOPMed gnomAD
rs777219665 CA7742345	10	E>K		No	ClinGen ExAC TOPMed gnomAD
CA393889571 rs777219665	10	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs752086762 CA7742342	11	A>T		No	ClinGen ExAC TOPMed gnomAD
rs199831268 CA7742341	12	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA393889555 rs1349453468	13	D>N		No	ClinGen TOPMed
rs1202338302 CA393889540	14	F>L		No	ClinGen gnomAD
rs1567144437 CA393889534	15	A>V		No	ClinGen Ensembl
CA274799223 rs958761340	16	A>V		No	ClinGen TOPMed gnomAD
rs766705648 CA7742338	17	R>C		No	ClinGen ExAC TOPMed gnomAD
rs760925729 CA7742337	18	K>R		No	ClinGen ExAC gnomAD
CA7742335 rs544321005	20	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7742336 rs544321005	20	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7742333 rs1358878150	21	Q>P		No	ClinGen gnomAD
rs1470658011 CA393889493	22	Q>H		No	ClinGen TOPMed
rs868041767 CA274799207	22	Q>K		No	ClinGen Ensembl
rs1233238066 CA393889496	22	Q>P		No	ClinGen TOPMed
CA274799200 rs868073323	23	R>L		No	ClinGen TOPMed gnomAD
CA393889487 rs868073323	23	R>P		No	ClinGen TOPMed gnomAD
rs868073323 CA274799205	23	R>Q		No	ClinGen TOPMed gnomAD
CA393889488 rs1282981463	23	R>W		No	ClinGen gnomAD
CA7742331 rs774256897	25	K>R		No	ClinGen ExAC gnomAD
CA393889466 rs1309944702	26	D>Y		No	ClinGen gnomAD
CA7742330 rs143797628	27	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs971343113 CA274799160	28	E>Q		No	ClinGen TOPMed
CA7742329 rs759526012	29	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1331344826 CA393889431	30	T>I		No	ClinGen TOPMed
rs907311994 CA274799146	31	P>A		No	ClinGen TOPMed
CA393889426 rs1388305826	31	P>L		No	ClinGen gnomAD
CA393889416 rs1372631798	32	Y>C		No	ClinGen TOPMed
CA393889390 rs1596201835	35	H>P		No	ClinGen Ensembl
CA7742306 rs772838683	38	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1359770881 CA393889264	39	V>G		No	ClinGen TOPMed gnomAD
rs771775211 CA393889267	39	V>L		No	ClinGen ExAC TOPMed gnomAD
CA7742305 rs771775211	39	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1596201103 CA393889261	40	A>S		No	ClinGen Ensembl
CA7742304 rs747731076	41	R>W		No	ClinGen ExAC gnomAD
CA7742302 rs149008342	45	H>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs780552478 CA7742300	47	A>V		No	ClinGen ExAC TOPMed gnomAD
CA393889215 rs1314691628	48	G>R		No	ClinGen TOPMed
CA393889201 rs1355938447	50	T>A		No	ClinGen TOPMed
CA393889197 rs1168108568	50	T>I		No	ClinGen gnomAD
CA393889185 rs1250275273	52	I>T		No	ClinGen TOPMed gnomAD
rs756539452 CA7742299	52	I>V		No	ClinGen ExAC gnomAD
rs1334268355 CA393889178	53	V>A		No	ClinGen TOPMed
rs1187006186 CA393889174	54	V>M		No	ClinGen gnomAD
CA393889160 rs1212362100	56	Q>R		No	ClinGen gnomAD
CA274798569 rs912023235	57	A>E		No	ClinGen Ensembl
rs747316900 CA7742277	60	L>P		No	ClinGen ExAC gnomAD
CA274798540 rs932374912	61	H>R		No	ClinGen Ensembl
CA7742275 rs758657403	62	D>E		No	ClinGen ExAC gnomAD
rs150464100 CA7742276	62	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA393889106 rs1196682827	63	T>M		No	ClinGen TOPMed
CA393889099 rs1183023614	64	V>G		No	ClinGen gnomAD
rs752850621 CA7742274	64	V>L		No	ClinGen ExAC TOPMed
rs752850621 CA393889103	64	V>M		No	ClinGen ExAC TOPMed
CA393889093 rs1466851985	65	E>V		No	ClinGen TOPMed
rs778839266 CA7742273	66	D>N		No	ClinGen ExAC gnomAD
CA393889067 rs1249943822	69	T>S		No	ClinGen gnomAD
rs921011364 CA274798520	70	T>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7742272 rs572934314	71	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7742271 rs554875348	72	D>H		No	ClinGen 1000Genomes ExAC gnomAD
CA393889016 rs1248220164	77	H>R		No	ClinGen gnomAD
rs1596200482 CA393888983	82	V>L		No	ClinGen Ensembl
CA393888968 rs1219033640	84	R>L		No	ClinGen gnomAD
CA393888962 rs1294968728	86	V>M		No	ClinGen TOPMed gnomAD
CA7742270 rs767405507	89	V>A		No	ClinGen ExAC gnomAD
CA393888937 rs767405507	89	V>E		No	ClinGen ExAC gnomAD
CA393888916 rs1229747659	92	D>V		No	ClinGen gnomAD
rs1374683597 CA393888911	93	K>Q		No	ClinGen TOPMed
rs377242953 CA7742268	94	T>I		No	ClinGen ESP ExAC
CA7742267 rs575157554	95	L>P		No	ClinGen 1000Genomes ExAC gnomAD
rs762569636 CA7742265	97	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1596200391 CA393888880	98	L>P		No	ClinGen Ensembl
CA393888878 rs1405160301	99	E>K		No	ClinGen TOPMed gnomAD
TCGA novel	101	K>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs375962566 CA274798454	102	R>S		No	ClinGen Ensembl
rs769180797 CA7742261	104	Q>P		No	ClinGen ExAC gnomAD
CA393888832 rs1596200342	105	V>G		No	ClinGen Ensembl
rs141515875 CA7742260	107	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs981666865 CA274798441	107	Q>P		No	ClinGen TOPMed
CA274798429 rs538623921	108	A>E		No	ClinGen 1000Genomes ExAC gnomAD
rs538623921 CA7742259	108	A>G		No	ClinGen 1000Genomes ExAC gnomAD
CA393888815 rs1160516034	108	A>S		No	ClinGen gnomAD
rs138596450 CA7742258	109	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144631975 CA7742257 COSM374202	110	H>D	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs778239014 CA7742256	110	H>P		No	ClinGen ExAC
rs140820485 CA274798422	111	S>N		No	ClinGen ESP
rs772475217 CA7742255	111	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1269694384 CA393888793	112	S>N		No	ClinGen gnomAD
CA7742254 rs779117867	112	S>R		No	ClinGen ExAC gnomAD
rs1488024232 CA393888786	113	P>L		No	ClinGen gnomAD
CA7742252 rs137864548	114	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	115	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753899170 CA7742250	117	L>R		No	ClinGen ExAC gnomAD
rs1326529539 CA393888763	117	L>V		No	ClinGen gnomAD
rs757146652 CA7742248	121	A>G		No	ClinGen ExAC gnomAD
rs1215151015 CA393888741	121	A>T		No	ClinGen TOPMed
CA7742245 rs763844356	123	K>R		No	ClinGen ExAC gnomAD
CA393888720 rs1437921030	124	L>V		No	ClinGen gnomAD
rs1024119139 CA274798353	127	L>V		No	ClinGen Ensembl
CA393888683 rs752276722	129	D>E		No	ClinGen ExAC TOPMed gnomAD
rs764882893 CA7742242	130	L>V		No	ClinGen ExAC gnomAD
rs372856910 CA7742241	131	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA393888666 rs1170542224	132	R>P		No	ClinGen gnomAD
CA7742240 rs776163027	134	T>A		No	ClinGen ExAC gnomAD
rs771591823 CA7742239	134	T>I		No	ClinGen ExAC gnomAD
rs761245831 CA7742238	135	P>A		No	ClinGen ExAC gnomAD
CA7742237 rs773755660	135	P>R		No	ClinGen ExAC gnomAD
rs1429036009 CA393888645	136	E>A		No	ClinGen TOPMed
CA393888648 rs1190199489	136	E>Q		No	ClinGen gnomAD
rs117318472 CA7742193	138	W>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1351146262 CA393888543	138	W>S		No	ClinGen gnomAD
CA393888535 rs1408249744	139	S>*		No	ClinGen TOPMed gnomAD
CA393888534 rs1408249744	139	S>L		No	ClinGen TOPMed gnomAD
TCGA novel	141	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA393888476 rs1406832767	147	F>L		No	ClinGen gnomAD
rs1324002141 CA393888479	147	F>S		No	ClinGen gnomAD
rs1164093409 CA393888468	148	E>D		No	ClinGen gnomAD
rs771948355 CA7742192	148	E>Q		No	ClinGen ExAC gnomAD
CA7742191 rs748092184	149	W>R		No	ClinGen ExAC TOPMed gnomAD
rs949916887 CA274797958	152	Q>K		No	ClinGen TOPMed gnomAD
rs778643169 CA7742190	153	V>M		No	ClinGen ExAC gnomAD
CA393888426 rs1354340201	155	K>T		No	ClinGen TOPMed
CA7742189 rs768487452 CA393888383	161	N>K		No	ClinGen ExAC TOPMed gnomAD
rs748980570 CA7742188	162	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1480411283 CA393888381	162	R>W		No	ClinGen gnomAD
CA393888376 rs1213609264	163	Q>*		No	ClinGen TOPMed gnomAD
rs1213609264 CA393888378	163	Q>K		No	ClinGen TOPMed gnomAD
rs1219721328 CA393888335	169	K>R		No	ClinGen TOPMed
CA393888310 rs1226608064	172	F>L		No	ClinGen gnomAD
rs1596199319 CA393888315	172	F>V		No	ClinGen Ensembl
rs1350259627 CA393888293	175	R>G		No	ClinGen gnomAD
CA274797940 rs757243903	175	R>P		No	ClinGen Ensembl
CA393888292 rs1350259627	175	R>W		No	ClinGen gnomAD
CA393888280 rs1206269893	177	L>P		No	ClinGen TOPMed
rs1438400408 CA393888278	178	T>P		No	ClinGen gnomAD
CA393888270 rs1250151572	179	I>F		No	ClinGen gnomAD
rs1196451828 CA393888266	179	I>M		No	ClinGen gnomAD

No associated diseases with Q8N4P3

2 regional properties for Q8N4P3

Type	Name	Position	InterPro Accession
domain	HD/PDEase domain	28 - 147	IPR003607
domain	HD domain	32 - 127	IPR006674

Functions

		Description
EC Number	3.1.7.2	Diphosphoric monoester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name	Definition
guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.
metal ion binding	Binding to a metal ion.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q7XAP4	RSH2	Probable GTP diphosphokinase RSH2, chloroplastic	Oryza sativa subsp japonica (Rice)	PR
Q67UU0	RSH3	Probable GTP diphosphokinase RSH3, chloroplastic	Oryza sativa subsp japonica (Rice)	PR

10	20	30	40	50	60
MGSEAAQLLE	AADFAARKHR	QQRRKDPEGT	PYINHPIGVA	RILTHEAGIT	DIVVLQAALL
70	80	90	100	110	120
HDTVEDTDTT	LDEVELHFGA	QVRRLVEEVT	DDKTLPKLER	KRLQVEQAPH	SSPGAKLVKL
130	140	150	160	170
ADKLYNLRDL	NRCTPEGWSE	HRVQEYFEWA	AQVVKGLQGT	NRQLEEALKH	LFKQRGLTI