Q8LRK8
PR
Gene name |
HDA18 |
Protein name |
Histone deacetylase 18 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G61070 |
EC number |
3.5.1.98: In linear amides |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8LRK8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8LRK8-F1 | Predicted | AlphaFoldDB |
90 variants for Q8LRK8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_24574369_G_T | 2 | L>I | No | 1000Genomes | |
| ENSVATH07459473 | 17 | S>P | No | 1000Genomes | |
| tmp_5_24574317_G_A | 19 | S>F | No | 1000Genomes | |
| ENSVATH07459472 | 20 | L>F | No | 1000Genomes | |
| tmp_5_24574287_G_A | 29 | S>L | No | 1000Genomes | |
| ENSVATH14643573 | 39 | E>V | No | 1000Genomes | |
| ENSVATH07459471 | 43 | K>E | No | 1000Genomes | |
| ENSVATH00745910 | 50 | G>R | No | 1000Genomes | |
| tmp_5_24574224_C_A | 50 | G>V | No | 1000Genomes | |
| ENSVATH03460385 | 55 | K>E | No | 1000Genomes | |
| ENSVATH00745909 | 56 | S>I | No | 1000Genomes | |
| tmp_5_24574097_C_A | 92 | K>N | No | 1000Genomes | |
| tmp_5_24574081_C_A | 98 | V>F | No | 1000Genomes | |
| ENSVATH12888432 | 103 | V>A | No | 1000Genomes | |
| tmp_5_24573697_C_T | 110 | A>T | No | 1000Genomes | |
| tmp_5_24573676_A_T | 117 | L>M | No | 1000Genomes | |
| tmp_5_24573532_A_G | 165 | S>P | No | 1000Genomes | |
| ENSVATH03460382 | 170 | A>T | No | 1000Genomes | |
| tmp_5_24573301_C_T | 207 | A>T | No | 1000Genomes | |
| ENSVATH12888428 | 223 | K>R | No | 1000Genomes | |
| ENSVATH07459455 | 225 | I>V | No | 1000Genomes | |
| ENSVATH03460381 | 229 | D>N | No | 1000Genomes | |
| tmp_5_24573057_C_T | 247 | R>H | No | 1000Genomes | |
| tmp_5_24572924_C_T | 259 | G>R | No | 1000Genomes | |
| tmp_5_24572918_A_C | 261 | F>V | No | 1000Genomes | |
| ENSVATH12888425 | 262 | Y>* | No | 1000Genomes | |
| ENSVATH07459450 | 262 | Y>F | No | 1000Genomes | |
| ENSVATH07459449 | 266 | D>N | No | 1000Genomes | |
| tmp_5_24572890_A_T | 270 | F>Y | No | 1000Genomes | |
| ENSVATH12888403 | 271 | N>H | No | 1000Genomes | |
| ENSVATH12888402 | 292 | C>F | No | 1000Genomes | |
| ENSVATH12888402 | 292 | C>Y | No | 1000Genomes | |
| ENSVATH14643570 | 312 | F>I | No | 1000Genomes | |
| tmp_5_24572745_C_G | 318 | L>F | No | 1000Genomes | |
| tmp_5_24572399_T_G | 364 | Y>S | No | 1000Genomes | |
| ENSVATH12888398 | 375 | A>V | No | 1000Genomes | |
| tmp_5_24572363_C_A | 376 | C>F | No | 1000Genomes | |
| tmp_5_24572349_G_T | 381 | L>I | No | 1000Genomes | |
| ENSVATH07459440 | 386 | I>T | No | 1000Genomes | |
| ENSVATH14643569 | 388 | G>D | No | 1000Genomes | |
| ENSVATH00745899 | 391 | E>V | No | 1000Genomes | |
| ENSVATH07459439 | 399 | R>P | No | 1000Genomes | |
| tmp_5_24572285_A_G | 402 | I>T | No | 1000Genomes | |
| tmp_5_24572133_C_T | 405 | V>I | No | 1000Genomes | |
| ENSVATH00745897 | 406 | R>H | No | 1000Genomes | |
| ENSVATH07459435 | 410 | C>Y | No | 1000Genomes | |
| ENSVATH07459434 | 411 | T>A | No | 1000Genomes | |
| ENSVATH00745896 | 417 | D>N | No | 1000Genomes | |
| tmp_5_24572093_G_A | 418 | A>V | No | 1000Genomes | |
| ENSVATH07459433 | 419 | S>L | No | 1000Genomes | |
| ENSVATH00745895 | 423 | N>S | No | 1000Genomes | |
| ENSVATH07459431 | 428 | N>I | No | 1000Genomes | |
| tmp_5_24572061_G_A | 429 | P>S | No | 1000Genomes | |
| tmp_5_24572055_C_T | 431 | A>T | No | 1000Genomes | |
| ENSVATH14643567 | 441 | R>C | No | 1000Genomes | |
| ENSVATH07459430 | 446 | L>F | No | 1000Genomes | |
| ENSVATH00745893 | 451 | A>V | No | 1000Genomes | |
| ENSVATH07459429 | 454 | D>H | No | 1000Genomes | |
| ENSVATH07459428 | 468 | N>Y | No | 1000Genomes | |
| ENSVATH12888396 | 480 | A>V | No | 1000Genomes | |
| ENSVATH00745892 | 481 | G>R | No | 1000Genomes | |
| tmp_5_24571886_G_T | 487 | A>D | No | 1000Genomes | |
| ENSVATH07459426 | 487 | A>S | No | 1000Genomes | |
| ENSVATH07459425 | 492 | I>N | No | 1000Genomes | |
| ENSVATH03460377 | 506 | R>Q | No | 1000Genomes | |
| tmp_5_24571803_G_A | 515 | R>C | No | 1000Genomes | |
| ENSVATH07459423 | 537 | C>Y | No | 1000Genomes | |
| ENSVATH00745890 | 538 | L>M | No | 1000Genomes | |
| ENSVATH00745889 | 540 | T>R | No | 1000Genomes | |
| tmp_5_24571710_C_T | 546 | E>K | No | 1000Genomes | |
| ENSVATH12888374 | 555 | D>E | No | 1000Genomes | |
| ENSVATH07459421 | 568 | M>L | No | 1000Genomes | |
| tmp_5_24571578_C_A | 590 | E>* | No | 1000Genomes | |
| ENSVATH07459419 | 598 | I>R | No | 1000Genomes | |
| tmp_5_24571518_G_C | 610 | R>G | No | 1000Genomes | |
| tmp_5_24571511_C_T | 612 | G>E | No | 1000Genomes | |
| ENSVATH12888371 | 628 | L>S | No | 1000Genomes | |
| ENSVATH12888370 | 629 | D>E | No | 1000Genomes | |
| ENSVATH12888366 | 636 | P>Q | No | 1000Genomes | |
| ENSVATH12888365 | 639 | N>Y | No | 1000Genomes | |
| ENSVATH00745885 | 644 | S>L | No | 1000Genomes | |
| ENSVATH00745884 | 656 | N>K | No | 1000Genomes | |
| ENSVATH07459414 | 665 | I>M | No | 1000Genomes | |
| ENSVATH07459412 | 671 | I>F | No | 1000Genomes | |
| ENSVATH07459411 | 673 | F>C | No | 1000Genomes | |
| ENSVATH07459410 | 673 | F>L | No | 1000Genomes | |
| ENSVATH00745883 | 674 | I>V | No | 1000Genomes | |
| tmp_5_24571323_C_T | 675 | A>T | No | 1000Genomes | |
| ENSVATH12888333 | 676 | S>N | No | 1000Genomes | |
| ENSVATH12888332 | 681 | V>A | No | 1000Genomes |
No associated diseases with Q8LRK8
1 regional properties for Q8LRK8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Histone deacetylase domain | 80 - 379 | IPR023801 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.5.1.98 | In linear amides |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| histone deacetylase complex | A protein complex that possesses histone deacetylase activity. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone deacetylase activity | Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. |
| zinc ion binding | Binding to a zinc ion (Zn). |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| histone deacetylation | The modification of histones by removal of acetyl groups. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| regulation of epidermal cell differentiation | Any process that modulates the frequency, rate or extent of epidermal cell differentiation. |
| root epidermal cell differentiation | The process in which a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLLKFEASSE | LRLVDPSVSL | TVLRKIRLSH | LPDMTMTSES | SGKKCGEGDG | KVAGKSQRKV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GLVYDETMCK | HDTPNGKVDV | ECPDRIRVIW | EKLQLAGVTQ | RCVVLGGSKA | EDKHLKLVHT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KKHVNLVKSI | STKKKDSRRN | KIASQLDSIY | LNGGSSEAAY | LAAGSVVKVA | EKVAEGELDC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GFAIVRPPGH | HAESDEAMGF | CLFNNVAVAA | SFLLNERPDL | DVKKILIVDW | DIHHGNGTQK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MFWKDSRVLI | FSVHRHDHGS | FYPFGDDGDF | NMVGEGPGEG | FNINVPWEQG | GCGDADYLAV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WNHILIPVTK | EFKPDIILLS | AGFDAAIGDP | LGGCCVTPYG | YSVMLKKLME | FAHGKIVLAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EGGYNLESLG | KSSLACVQVL | LEDKQIHGSS | ETYPLESTRR | VIQAVRERLC | TYWPSLDASM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ASNENLKNPS | AERNSADALL | REVEELKSLM | AARDGELEAR | RKELKAKNKE | LEANEKELEA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GLMLIRARED | VICGLHAKIE | SLQQERDEAV | AKAERIDKEL | QEDRARSQEF | KEDTEFCLST |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LRREKELAIM | AKNKDLEAKE | KELEARLMLV | HAREDKIHAK | IERLQQERDE | AVAKAERIDK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ELQEDRSRSR | VGNGSFAFSQ | EFYEDMDLDE | LEPLSPEFNE | DMDSEELEPF | QVIKKNMERS |
| 670 | 680 | ||||
| HKKFIKDMEC | IKFIASERAR | VL |