Q8LEE8
Gene name |
LIP1P |
Protein name |
Lipoyl synthase, chloroplastic |
Names |
Lipoate synthase, LS, Lip-syn, Lipoate synthase, plastidial, LIP1p, Lipoic acid synthase |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G08415 |
EC number |
2.8.1.8: Sulfurtransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8LEE8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8LEE8-F1 | Predicted | AlphaFoldDB |
21 variants for Q8LEE8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH03037735 | 2 | M>T | No | 1000Genomes | |
| tmp_5_2713009_C_A | 31 | L>F | No | 1000Genomes | |
| ENSVATH00612171 | 37 | C>R | No | 1000Genomes | |
| ENSVATH00612170 | 49 | K>N | No | 1000Genomes | |
| tmp_5_2712938_G_A | 55 | S>L | No | 1000Genomes | |
| tmp_5_2712928_C_G | 58 | E>D | No | 1000Genomes | |
| tmp_5_2712927_C_T | 59 | D>N | No | 1000Genomes | |
| ENSVATH03037734 | 68 | M>I | No | 1000Genomes | |
| ENSVATH06941327 | 75 | S>N | No | 1000Genomes | |
| tmp_5_2712777_C_G | 109 | E>Q | No | 1000Genomes | |
| tmp_5_2712763_C_A | 113 | E>D | No | 1000Genomes | |
| tmp_5_2712145_C_A | 193 | V>L | No | 1000Genomes | |
| ENSVATH00612168 | 226 | P>L | Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| ENSVATH06941318 | 275 | G>R | No | 1000Genomes | |
| ENSVATH06941312 | 290 | K>I | No | 1000Genomes | |
| tmp_5_2711471_C_T | 308 | E>K | No | 1000Genomes | |
| ENSVATH10652891 | 321 | D>E | No | 1000Genomes | |
| tmp_5_2711253_C_G | 340 | V>L | No | 1000Genomes | |
| tmp_5_2711241_C_T | 344 | V>I | No | 1000Genomes | |
| ENSVATH06941308 | 350 | D>N | No | 1000Genomes | |
| tmp_5_2711017_A_G | 384 | M>T | No | 1000Genomes |
No associated diseases with Q8LEE8
Functions
| Description | ||
|---|---|---|
| EC Number | 2.8.1.8 | Sulfurtransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| lipoate synthase activity | Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl. |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| lipoate biosynthetic process | The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. |
| protein lipoylation | The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5BIP7 | LIAS | Lipoyl synthase, mitochondrial | Bos taurus (Bovine) | PR |
| Q7JQW6 | Las | Lipoyl synthase, mitochondrial | Drosophila melanogaster (Fruit fly) | PR |
| O43766 | LIAS | Lipoyl synthase, mitochondrial | Homo sapiens (Human) | PR |
| B6TN12 | LIP1P-1 | Lipoyl synthase 1, chloroplastic | Zea mays (Maize) | PR |
| B9I666 | LIP1P-1 | Lipoyl synthase 1, chloroplastic | Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) | PR |
| B9N2B0 | LIP1P-2 | Lipoyl synthase 2, chloroplastic | Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) | PR |
| Q5XIH4 | Lias | Lipoyl synthase, mitochondrial | Rattus norvegicus (Rat) | PR |
| Q5ZAQ2 | LIP1P-1 | Lipoyl synthase 1, chloroplastic | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MMHHCSITKP | TFSISISTQK | LHHHSSKFLN | LGFRIRCESG | DVSSPLRTKA | VSLSSEMEDS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSLKKSLMEL | EGKKSEPYPG | GMPKMGPFTG | RDPNVKKPAW | LRQKAPQGER | FQEVKESLSR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LNLNTVCEEA | QCPNIGECWN | GGGDGVATAT | IMVLGDTCTR | GCRFCAVKTS | RNPPPPDPME |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PENTAKAIAS | WGVDYIVITS | VDRDDIPDGG | SGHFAQTVKA | MKRHKPDIMI | ECLTSDFRGD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LEAVDTLVHS | GLDVFAHNVE | TVKRLQRLVR | DPRAGYEQSM | SVLKHAKISK | PGMITKTSIM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGLGETDEEL | KEAMADLRAI | DVDILTLGQY | LQPTPLHLTV | KEYVTPEKFD | FWKTYGESIG |
| 370 | 380 | 390 | |||
| FRYVASGPLV | RSSYRAGELF | VKTMVKESYS | KSLS |