AiPD: Autoinhibited Protein Database

Gene name	LIAS
Protein name	Lipoyl synthase, mitochondrial
Names	Lipoate synthase, LS, Lip-syn, Lipoic acid synthase
Species	Bos taurus (Bovine)
KEGG Pathway	bta:530865
EC number	2.8.1.8: Sulfurtransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-105 (Predicted disordered autoinhibitory region) PR

1-105 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q5BIP7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs452181238	16	V>E	No	EVA
rs472376478	21	V>G	No	EVA
rs440871499	50	S>C	No	EVA
rs464009156	67	K>T	No	EVA
rs470544468	84	I>M	No	EVA
rs453491864	92	K>E	No	EVA
rs453491864	92	K>Q	No	EVA
rs442231426	94	K>E	No	EVA
rs462347178	98	R>W	No	EVA
rs475736480	100	L>V	No	EVA
rs449130731	118	W>C	No	EVA
rs134264166	126	A>P	No	EVA
rs135655447	127	T>P	No	EVA
rs480356498	142	R>G	No	EVA
rs211447555	158	N>S	No	EVA
rs1116041948	167	I>V	No	EVA
rs43463545	179	S>F	No	EVA
rs445459687	188	G>*	No	EVA
rs453892884	206	K>N	No	EVA
rs467421549	227	A>G	No	EVA
rs436188669	232	D>N	No	EVA
rs456156484	240	T>K	No	EVA
rs383164309	242	P>Q	No	EVA
rs476163485	243	E>*	No	EVA
rs481803679	247	K>T	No	EVA
rs723120812	279	M>I	No	EVA
rs442097144	297	R>C	No	EVA
rs1114511767	303	C>Y	No	EVA
rs455641313	307	G>*	No	EVA
rs444428383	312	P>T	No	EVA
rs467788859	362	N>H	No	EVA
rs436416145	365	A>V	No	EVA
rs469350283	366	K>*	No	EVA

Type	Name	Position	InterPro Accession
domain	Elp3/MiaA/NifB-like, radical SAM core domain	127 - 333	IPR006638
domain	Radical SAM	67 - 362	IPR007197
domain	Lipoyl synthase, N-terminal	4 - 111	IPR031691

		Description
EC Number	2.8.1.8	Sulfurtransferases
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
4 iron, 4 sulfur cluster binding	Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
lipoate synthase activity	Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
metal ion binding	Binding to a metal ion.

Name	Definition
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
lipoate biosynthetic process	The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid.
neural tube closure	The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
protein lipoylation	The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.
response to lipopolysaccharide	Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
response to oxidative stress	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q7JQW6	Las	Lipoyl synthase, mitochondrial	Drosophila melanogaster (Fruit fly)	PR
O43766	LIAS	Lipoyl synthase, mitochondrial	Homo sapiens (Human)	PR
B6TN12	LIP1P-1	Lipoyl synthase 1, chloroplastic	Zea mays (Maize)	PR
B9I666	LIP1P-1	Lipoyl synthase 1, chloroplastic	Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)	PR
B9N2B0	LIP1P-2	Lipoyl synthase 2, chloroplastic	Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)	PR
Q5XIH4	Lias	Lipoyl synthase, mitochondrial	Rattus norvegicus (Rat)	PR
Q5ZAQ2	LIP1P-1	Lipoyl synthase 1, chloroplastic	Oryza sativa subsp japonica (Rice)	PR
Q8LEE8	LIP1P	Lipoyl synthase, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR