Q5XIH4
Gene name |
Lias |
Protein name |
Lipoyl synthase, mitochondrial |
Names |
Lipoate synthase, LS, Lip-syn, Lipoic acid synthase |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:305348 |
EC number |
2.8.1.8: Sulfurtransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5XIH4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5XIH4-F1 | Predicted | AlphaFoldDB |
No variants for Q5XIH4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5XIH4 | |||||
No associated diseases with Q5XIH4
Functions
| Description | ||
|---|---|---|
| EC Number | 2.8.1.8 | Sulfurtransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| lipoate synthase activity | Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl. |
| metal ion binding | Binding to a metal ion. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| lipoate biosynthetic process | The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. |
| neural tube closure | The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. |
| protein lipoylation | The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine. |
| response to lipopolysaccharide | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
| response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5BIP7 | LIAS | Lipoyl synthase, mitochondrial | Bos taurus (Bovine) | PR |
| Q7JQW6 | Las | Lipoyl synthase, mitochondrial | Drosophila melanogaster (Fruit fly) | PR |
| O43766 | LIAS | Lipoyl synthase, mitochondrial | Homo sapiens (Human) | PR |
| B6TN12 | LIP1P-1 | Lipoyl synthase 1, chloroplastic | Zea mays (Maize) | PR |
| B9I666 | LIP1P-1 | Lipoyl synthase 1, chloroplastic | Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) | PR |
| B9N2B0 | LIP1P-2 | Lipoyl synthase 2, chloroplastic | Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) | PR |
| Q5ZAQ2 | LIP1P-1 | Lipoyl synthase 1, chloroplastic | Oryza sativa subsp japonica (Rice) | PR |
| Q8LEE8 | LIP1P | Lipoyl synthase, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALRCWDAAR | SLGSRIFGRY | ACSVRALSSL | PDEKKKFLHN | GPDLQDFVSG | DLADKSTWDD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YKGNLKRQKG | ERLRLPPWLK | TKIPMGKNYN | KLKNTLRNLN | LHTVCEEARC | PNIGECWGGG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EYATATATIM | LMGDTCTRGC | RFCSVKTARN | PPPLDPSEPD | NTARAIAEWG | LDYVVLTSVD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RDDVVDGGAE | HIAKTVSCLK | ERNPKILVEC | LTPDFRGDLR | AVEKVALSGL | DVYAHNVETV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PELQRKVRDP | RANFDQSLRV | LKHAKEVQPD | VVSKTSIMLG | LGETDEQVYA | TMKALRAADV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DCLTLGQYMQ | PTKRHLKVEE | YVTPEKFKYW | EEVGNELGFH | YTASGPLVRS | SYKAGEFFLK |
| 370 | |||||
| NLVAKRKTKV | SKV |